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Chemical Structure| 1558024-07-9 Chemical Structure| 1558024-07-9

Structure of 1558024-07-9

Chemical Structure| 1558024-07-9

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Product Details of [ 1558024-07-9 ]

CAS No. :1558024-07-9
Formula : C12H11NO
M.W : 185.22
SMILES Code : COC=CC1=C2N=CC=CC2=CC=C1
English Name :8-(2-Methoxyvinyl)quinoline

Safety of [ 1558024-07-9 ]

Application In Synthesis of [ 1558024-07-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1558024-07-9 ]

[ 1558024-07-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1558024-07-9 ]
  • [ 191228-36-1 ]
YieldReaction ConditionsOperation in experiment
54% With hydrogenchloride In water; acetone for 3h; Reflux; 4.7 4.1.7 2-(Quinolin-8-yl)acetaldehyde (16a) Compound 15a (30 mg, 0.162 mmol) was dissolved in acetone (1.0 mL) and then 6 N HCl (405 μL) was added dropwise. The mixture was refluxed for 3 h. The solvent was evaporated and the resulting aqueous mixture was taken to pH = 8 with saturated aqueous NaHCO3. The aqueous layer was extracted with EtOAc (3 * 20 mL). The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by flash chromatography on silica gel (30% EtOAc in n-hexane) to afford the title compound as a red oil (54% yield). 1H NMR (CDCl3, 300 MHz) δ 9.93 (s, 1H), 8.91 (dd, 1H, J1 = 1.8 Hz, J2 = 4.2 Hz), 8.18 (dd, 1H, J1 = 1.2 Hz, J2 = 8.1 Hz), 7.80 (d, 1H, J = 8.1 Hz), 7.61-7.41 (m, 3H), 4.28 (s, 2H); ESI-MS m/z 180 [M+Na]+.
 

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