[ CAS No. 156237-78-4 ] {[proInfo.proName]}

Name: 156237-78-4|1-tert-Butyl 2-methyl 4-bromo-1H-pyrrole-1,2-dicarboxylate|97%
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Product Details of [ 156237-78-4 ]

CAS No. :	156237-78-4	MDL No. :	MFCD09751125
Formula :	C₁₁H₁₄BrNO₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	BLWTUIPDLAVPHI-UHFFFAOYSA-N
M.W :	304.14	Pubchem ID :	11722547
Synonyms :

Safety of [ 156237-78-4 ]

Signal Word:	Danger	Class:	6.1
Precautionary Statements:	P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501	UN#:	2810
Hazard Statements:	H301-H311-H331	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 156237-78-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 156237-78-4 ]

[ 156237-78-4 ] Synthesis Path-Downstream 1~8

1
[ 24424-99-5 ]
[ 934-05-4 ]
[ 156237-78-4 ]

Yield	Reaction Conditions	Operation in experiment
95%	With dmap; In acetonitrile; at 20℃; for 2h;	At r.t., boc anhydride (3.94 g, 18 mmol) was added to the solution of 30-1 (3.07 g, 15 mmol) in MeCN (50 mL), followed by addition of DMAP (0.37 g, 3 mmol). After stirring for 2h, the solvent was evaporated and the residue was dissolved with ethyl acetate (50 mL), and washed with sat. aq. NH4Cl (50 mL). The organic layer was dried over Na2S04, evaporated in vacuo, and subject to flash chromatography to get the title compound as a colorless liquid (4.4 g, yield 95%). 1 H NMR (600 MHz, Chloroform- ) d 7.30 (d, J = 1.9 Hz, 1H), 6.78 (d, J = 1.9 Hz, 1H), 3.84 (s, 3H), 1.57 (s, 9H).
64 g	With dmap; triethylamine; In dichloromethane; at 20℃; for 3h;	To a mixture of 4-bromo-lH-pyrrole-2-carboxylic acid methyl ester (45 g, 221 mmol), DMAP (2.5 g, 22 mmol) and Et3N (22.3 g, 220 mmol) in CH2C12 (300 mL) was added a solution of Boc20 (53 g, 243 mmol) in CH2C12 (100 mL) dropwise over 30 minutes at room temperature. After being stirred at room temperature for 3 hours, the mixture was concentrated. The residue was diluted with petroleum ether (300 mL). The resulting suspension was filtered and the filtrate was washed with water (300 mLx3), followed by brine (50 mL). The organic layer was dried over anhydrous Na2S04 and then concentrated to give 4-bromo-pyrrole-l,2-dicarboxylic acid 1- tert-butyl ester 2-methyl ester (64 g) as a white solid.
	With dmap; In acetonitrile; at 0 - 25℃; for 2h;	To a solution of <strong>[934-05-4]methyl 4-bromo-1H-pyrrole-2-carboxylate</strong> (120 g, 588 mmol, 1.0 eq.) in MeCN (1200 mL) was added DMAP (7.2 g, 58 mmol, 0.1 eq.) followed by (Boc)2O (141 g, 647 mmol, 1.1 eq.) at 0 C. The mixture was stirred at 25 C. for 2 hr. The mixture was concentrated and the residue was dissolved in ethyl acetate (2.0 L). The solution was washed with ice 1M HCl (200 mL*2), sat.aq.NaHCO3 (200 mL) and brine (100 mL). The organic phase was dried over anhydrous Na2SO4, filtered and concentrated in vacuum to give crude 1-tert-butyl 2-methyl 4-bromo-1H-pyrrole-1,2-dicarboxylate (174 g) as a yellow oil, which was used into the next step without further purification. TLC: Rf=0.77 (Petroleum ether:Ethyl acetate=5:1). 1H NMR (400 MHz, CHLOROFORM-d) delta=7.29 (d, J=1.8 Hz, 1H), 6.77 (d, J=1.3 Hz, 1H), 3.82 (s, 3H), 1.56 (s, 9H).

	With dmap; In acetonitrile;	Int-19C was prepared using the procedure described in: DespSat, V . et. al, Journal of Enzyme Inhibition and Medicinal Chemistry 2010, 25, 204. NMR (500MHz, CDCh) delta 7.31 (d, J= 1.9 Hz, 1H), 6.79 (d, J = 1.9 Hz, 1H), 3.85 (s, 3H), 1.58 (s, 9H). LCMS (ES): m/z 249.9 [M-tBu+H]+.
	With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25℃; for 12h;	N,N-dimethylpyridin-4-amine (0.30 g, 2.5 mmol) was added to a solution of methyl 4- bromo-l//-pyrrole-2-carboxylate (1.0 g, 4.9 mmol), di-/er/-butyl dicarbonate (1.4 g, 6.4 mmol) and triethylamine (2.0 mL, 15 mmol) in DCM (20 mL), and the reaction mixture was stirred at 25 C for 12 h. The mixture was diluted with water and extracted with DCM. The combined organic phase was washed with brine, dried over anhydrous Na2S04, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (EtOAc in hexanes) to give 1 -/t V-butyl 2-methyl 4-bromo-l//-pyrrole-l, 2-dicarboxylate. LCMS (C7H7BrN04+) (ES, m/z): 248 [M-C4H8+H]+.

Reference： [1]Patent: WO2019/236957,2019,A1 .Location in patent: Page/Page column 94; 95
[2]Journal of Organic Chemistry,1994,vol. 59,p. 2456 - 2466
[3]European Journal of Medicinal Chemistry,2013,vol. 65,p. 205 - 222
[4]Patent: WO2014/154723,2014,A1 .Location in patent: Page/Page column 29
[5]Patent: US2017/190713,2017,A1 .Location in patent: Paragraph 0185
[6]Patent: WO2018/89360,2018,A1 .Location in patent: Page/Page column 69
[7]Patent: WO2019/94319,2019,A1 .Location in patent: Page/Page column 40-41
[8]Patent: WO2019/177873,2019,A1 .Location in patent: Page/Page column 112

2
[ 156237-78-4 ]
[ 73183-34-3 ]
[ 942070-38-4 ]

Yield	Reaction Conditions	Operation in experiment
4.1 g	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 100℃; for 3h; Inert atmosphere;	1.3 Step 3: Preparation of 4-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl)-pyrrole-l,2- dicarboxylic acid 1-tert-butyl ester 2-methyl ester A mixture of 4-bromo-pyrrole-l,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (10 g, 33 mmol), bis(pinacolato)diboron (18 g, 66 mmol), KOAc (6.2 g, 66 mmol), Pd(dppf)Cl2 (1 g, 1.5 mmol) in 1,4-dioxane (150 mL) under nitrogen protection was stirred at 100 °C for 3 hours. The mixture was filtered through a Celite pad, and the filtrate was concentrated. The residue was purified by column chromatography to give 4-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl)- pyrrole-l,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (4.1 g) as a white solid.
180 g	With bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 100℃; for 3h; Inert atmosphere;	Step 2: Preparation of compound M6 The compound M6-2 (100.000g) and pinacol diborate (167.000g) were dissolved in dioxane (500mL), potassium acetate (81.000g), (PPh3)2PdCl2 (5.000g) and Pd(dppf)2Cl2 (5.000g) were added, vacuum N2 replacement three times, the mixture was incubated at 100°C and reacted for 3hrs. After the reaction was completed, cooled down to below 50°C, desolvated, added petroleum ether (500mL), filtered, after desolventization, added petroleum ether (1000mL) again, stired for 45min, filtered. The filtrated was cooled to 0-5°C, there was solid precipitation , which was filtered and dried to obtain 180.000 g of compound. LC-MS [M+H]+=352.2.

Reference： [1]Current Patent Assignee: ROCHE HOLDING AG - WO2014/154723, 2014, A1 Location in patent: Page/Page column 29-30
[2]Current Patent Assignee: BETTA PHARMACEUTICALS CO LTD - EP3805217, 2021, A1 Location in patent: Paragraph 0098; 0100

3
[ 126747-14-6 ]
[ 156237-78-4 ]
1-tert-butyl 2-methyl 4-(4-cyanophenyl)-1H-pyrrole-1,2-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; di-<i>tert</i>-butyl dicarbonate; sodium carbonate In 1,4-dioxane; water at 80 - 100℃; for 12h; Inert atmosphere;	A.1 1-tert-butyl 2-methyl 4-(4-cyanophenyl)-1H-pyrrole-1,2-dicarboxylate, S3 A suspension of 1-tert-butyl 2-methyl 4-bromo-1H-pyrrole-1,2-dicarboxylate (131 g, 432 mmol, 1.0 eq.), (4-cyanophenyl)boronic acid (95.3 g, 648.5 mmol, 1.5 eq.), Na2CO3 (91 g, 864 mmol, 2.0 eq) and (Boc)2O (141 g, 648 mmol, 1.5 eq.), Pd(dppf)Cl2 (15.8 g, 21.6 mmol, 0.05 eq.) in dioxane/H2O (4.9 L, 10:1) was de-gassed and then heated to 80˜100° C. for 12 hr under N2. The mixture was concentrated under reduced pressure and the residue was portioned between Ethyl acetate (3.0 L) and brine (500 mL). The organic layer was dried over anhydrous Na2SO4, filtered and concentrated to give crude 1-tert-butyl 2-methyl 4-(4-cyanophenyl)-1H-pyrrole-1,2-dicarboxylate (150 g) as a yellow oil which was used into the next step without further purification. ESI [M+H]=327.2

Reference： [1]Current Patent Assignee: TABOMEDEX BIOSCIENCES - US2017/190713, 2017, A1 Location in patent: Paragraph 0186

4
[ 1765-93-1 ]
[ 156237-78-4 ]
1-tert-butyl 2-methyl 4-(4-fluorophenyl)-1H-pyrrole-1,2-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; di-<i>tert</i>-butyl dicarbonate; sodium carbonate In 1,4-dioxane; water at 100℃; for 12h;	A.31 1-tert-butyl 2-methyl 4-(4-fluorophenyl)-1H-pyrrole-1,2-dicarboxylate, S108 To a mixture of 1-tert-butyl 2-methyl 4-bromo-1H-pyrrole-1,2-dicarboxylate (59.8 g, 196.6 mmol, 1.0 eq.) and (4-fluorophenyl)boronic acid (41 g, 294 mmol, 1.5 eq.) in dioxane (1.8 L) and H2O (180 mL) was added Boc2O (64.3 g, 294.9 mmol, 1.50 eq.), Na2CO3 (41.68 g, 393.24 mmol, 2.00 eq.) and Pd(dppf)Cl2 (7.1 g, 9.8 mmol, 0.05 eq.). The mixture was stirred at 100° C. for 12 hr and then concentrated. The residue was partitioned between ethyl acetate/THF (700 mL/100 mL) and water (500 mL). The organic layer was washed with brine (400 mL), dried over anhydrous MgSO4, filtered and concentrated to provide 1-tert-butyl 2-methyl 4-(4-fluorophenyl)-1H-pyrrole-1,2-dicarboxylate (75 g, crude, black solid). ESI [M+H]=320.1

Reference： [1]Current Patent Assignee: TABOMEDEX BIOSCIENCES - US2017/190713, 2017, A1 Location in patent: Paragraph 0311

5
[ 78-94-4 ]
[ 156237-78-4 ]
1-(tert-butyl) 2-methyl (E)-4-(3-oxobut-1-en-1-yl)-1H-pyrrole-1,2-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
38%	With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine In acetonitrile at 90℃; for 17h; Inert atmosphere;	Int-19D. 1 -(tot-Butyl) 2-methyl (£)-4-(3-oxobut-l-en-l-yl)-lH-pyrrole-l,2- dicarboxylate: A solution of Int-19C (0.100 g, 0.329 mmol), but-3-en-2-one (0.027 mL, 0.329 mmol), triethylamine (0.124 mL, 0.888 mmol), palladium acetate (8.3 mg, 0.037 mmol) and tri-o-tolylphosphine (17 mg , 0.055 mmol) in ACN (0.110 mL) was degassed with argon and then heated at 90 °C for 17 h. The solvent was removed in vacuo and the residue was purified by flash chromatography (silica gel, hexanes:EtOAc, 100:0 to 75:25) to yield Im-19D (36.7 mg, 38 %) as a white solid. NMR (500 MHz, CDCh) δ 7.53 (d, J = 1.9 Hz, 1H), 7.36 (d, J= 16.0 Hz, 1H), 7.01 (d, J= 1.9 Hz, 1H), 6.48 (d, J = 16.2 Hz, 1H), 3.88 (s, 3H), 2.33 (s, 3H), 1.60 (s, 9H). HPLC retention time HPLC retention time (Method 1): 3.193 min.; LCMS (ES): m/z 294.1 [M+H]+.

Reference： [1]Current Patent Assignee: BRISTOL-MYERS SQUIBB CO - WO2018/89360, 2018, A1 Location in patent: Page/Page column 69

6
[ 156237-78-4 ]
[ 98-80-6 ]
methyl 4-phenyl-1H-pyrrole-2-carboxylate [ No CAS ]
1-tert-butyl 2-methyl 4-phenyl-1H-pyrrole-1,2-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 76% 2: 5%	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate In 1,4-dioxane; water at 90℃; for 2h; Inert atmosphere;	3.3. Typical Procedure to Synthesize Products 3a-s General procedure: Dioxane (8 mL) and H2O (2 mL) were added to the mixture of 1a-q (1.5 mmol), 2a-c (1 mmol),Cs2CO3 (652 mg, 2 mmol), and Pd(PPh3)4 (116 mg, 0.1 mmol) under Ar2 atmosphere. The reaction mixture was stirred at 90 °C for about 5 h (monitored by Thin Layer Chromatography) and cooled to rt.Then, the mixture was filtered to remove the solids, and the filtrate was concentrated. Purification by flash chromatography (EtOAc in PE = 3%) gave the desired product.Methyl 4-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrole-2-carboxylate (3a). Colorless oil, 85% yield.1H-NMR (400 MHz, DMSO-d6) δ: 7.80 (d, J = 1.2 Hz, 1H, Pyrrole-5H), 7.61 (d, J = 8.0 Hz, 2H, Ar-2,6H),7.36-7.32 (m, 3H, Ar-3,5H, Pyrrole-3H), 7.19 (t, J = 8.0 Hz, 1H, Ar-4H), 5.64 (s, 2H, NCH2O), 3.77 (s, 3H,CH3), 3.50 (t, J = 7.6 Hz, 2H, OCH2CH2Si), 0.82 (t, J = 7.6 Hz, 2H, OCH2CH2Si), 0.07 (s, 9H, Si(CH3)3).13C-NMR (100 MHz, DMSO-d6) δ: 161.0, 134.2, 129.2, 127.4, 126.6, 125.2, 123.9, 122.7, 116.1, 76.9, 65.6,51.6, 17.6, 1.0. HRMS (ESI): m/z [M + H]+ calcd for C18H26NO3Si: 332.1677; found: 332.1662.

Reference： [1]Cui, Keli; Gao, Meng; Zhao, Hongyi; Zhang, Dongfeng; Yan, Hong; Huang, Haihong [Molecules, 2019, vol. 24, # 8]

7
[ 156237-78-4 ]
potassium vinyltrifluoroborate [ No CAS ]
1-tert-butyl 2-methyl 4-vinyl-1H-pyrrole-1,2-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 80℃; for 4h; Inert atmosphere;
	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 80℃; for 4h; Inert atmosphere;	18.2 A mixture of l-/er/-butyl 2-methyl 4-bromo-l //-pyrrole- 1 ,2-di carboxyl ate (350 mg, 1.2 mmol), potassium trifluoro(vinyl)borate (308 mg, 2.3 mmol), [I,G- (0937) Bis(diphenylphosphino)ferrocene]palladium(II) di chloride (168 mg, 0.23 mmol) and K2C03 (477 mg, 3.5 mmol) in water (0.50 mL) and l,4-Dioxane (5.0 mL) was degassed and backfilled with nitrogen (three times), and then heated to 80 °C for 4 h. The mixture was concentrated under reduced pressure, and the crude mixture was diluted with water, and extracted with EtOAc. The combined organic layer was washed with brine, dried over anhydrous Na2S04, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (EtOAc in hexanes) to give 1 -/t V-butyl 2-methyl 4-vinyl- l//-pyrrole- 1,2- di carboxyl ate. LCMS (C9HI0NO +) (ES, m/z): 196 [M-C H8+H]+.

Reference： [1]Lu, Min; Zhang, Hongjun; Li, Derun; Childers, Matthew; Pu, Qinglin; Palte, Rachel L.; Gathiaka, Symon; Lyons, Thomas W.; Palani, Anandan; Fan, Peter W.; Spacciapoli, Peter; Miller, J. Richard; Cho, Hyelim; Cheng, Mangeng; Chakravarthy, Kalyan; O'Neil, Jennifer; Eangoor, Padmanabhan; Beard, Adam; Kim, Hai-Young; Saurí, Josep; Gunaydin, Hakan; Sloman, David L.; Siliphaivanh, Phieng; Cumming, Jared; Fischer, Christian [ACS Medicinal Chemistry Letters, 2021, vol. 12, # 9, p. 1380 - 1388]
[2]Current Patent Assignee: MERCK & CO INC - WO2019/177873, 2019, A1 Location in patent: Page/Page column 112

8
[ 156237-78-4 ]
potassium isopropenyltrifluoroborane [ No CAS ]
1-(tert-butyl) 2-methyl 4-(prop-1-en-2-yl)-1H-pyrrole-1,2-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
81%	With palladium diacetate; caesium carbonate; triphenylphosphine In tetrahydrofuran; water at 80℃;	2 1-(tert-Butyl) 2-methyl 4-(prop- 1 -en-2-yl)- 1 H-pyrrole- 1 ,2-dicarboxylate (30-3). 1To a solution of 30-2 (3.8 g, 12.5 mmol) in THF (60 mL) and water (12 mL), potassium isopropenyl- trifluoroborate (3.7 mg, 25 mmol), CS2CO3 (12.2 g, 37.5 mmol), PPI13 (328 mg, 1.25 mmol) and Pd(OAc)2 (140 mg, 0.625 mmol) was added. The mixture was heated to 80 °C overnight. The solvent was evaporated under pressure, then the residue was dissolved with ethyl acetate (50 mL) and washed with sat. aq. NaCl (50 mL). The organic phase was dried over Na2S04, filtered, and evaporated in vacuo and subject to flash chromatography to obtain 30-3 as a colorless liquid (2.7 g, yield 81%). 1 H NMR (400 MHz, Chloroform-

Reference： [1]Current Patent Assignee: UNIVERSITY OF MICHIGAN - WO2019/236957, 2019, A1 Location in patent: Page/Page column 94; 95

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P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 156237-78-4 ] {[proInfo.proName]}

Quality Control of [ 156237-78-4 ]

Related Doc. of [ 156237-78-4 ]

Product Details of [ 156237-78-4 ]

Safety of [ 156237-78-4 ]

Application In Synthesis of [ 156237-78-4 ]

[ 156237-78-4 ] Synthesis Path-Downstream 1~8

Related Functional Groups of [ 156237-78-4 ]

Bromides

Amides

Esters

Related Parent Nucleus of [ 156237-78-4 ]

Pyrroles

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 156237-78-4 ]

Related Parent Nucleus of
[ 156237-78-4 ]