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[ CAS No. 15644-80-1 ]

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Chemical Structure| 15644-80-1
Chemical Structure| 15644-80-1
Structure of 15644-80-1 * Storage: {[proInfo.prStorage]}

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Product Details of [ 15644-80-1 ]

CAS No. :15644-80-1 MDL No. :MFCD00100264
Formula : C11H11NO Boiling Point : 292.4°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :173.21 g/mol Pubchem ID :-
Synonyms :

Safety of [ 15644-80-1 ]

Signal Word:Danger Class:8
Precautionary Statements:P264-P270-P280-P301+P312-P305+P351+P338-P310-P330-P501 UN#:1759
Hazard Statements:H302-H318 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 15644-80-1 ]

  • Downstream synthetic route of [ 15644-80-1 ]

[ 15644-80-1 ] Synthesis Path-Downstream   1~16

  • 1
  • [ 50-00-0 ]
  • [ 15644-80-1 ]
  • 5,7-dimethyl-4<i>H</i>-[1,3]dioxino[5,4-<i>c</i>]quinoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid
  • 2
  • [ 15644-80-1 ]
  • [ 2832-19-1 ]
  • chloro-acetic acid-[(4-hydroxy-2,8-dimethyl-[3]quinolylmethyl)-amide] [ No CAS ]
  • 3
  • [ 15644-80-1 ]
  • [ 100-34-5 ]
  • <i>N</i>-(4-hydroxy-2,8-dimethyl-[3]quinolyl)-acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide Erwaermen mit SnCl2 und konz. wss. HCl und Behandeln mit Acetanhydrid und wss. Natriumacetat;
  • 4
  • [ 15644-80-1 ]
  • [ 98-88-4 ]
  • [ 111947-00-3 ]
YieldReaction ConditionsOperation in experiment
With aluminium trichloride at 160℃;
  • 6
  • [ 15644-80-1 ]
  • [ 100-10-7 ]
  • 2-(4-dimethylamino-<i>trans</i>-styryl)-8-methyl-quinolin-4-ol [ No CAS ]
YieldReaction ConditionsOperation in experiment
With ethanol; zinc-chloride-hydroxide; acetic anhydride
  • 7
  • [ 15644-80-1 ]
  • [ 876385-42-1 ]
YieldReaction ConditionsOperation in experiment
With phosphorous (V) sulfide
  • 8
  • [ 33240-19-6 ]
  • [ 15644-80-1 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; acetic anhydride
  • 9
  • [ 141-97-9 ]
  • [ 95-53-4 ]
  • [ 15644-80-1 ]
YieldReaction ConditionsOperation in experiment
at 20℃; beim Erhitzen des erhaltenen β-o-Tolylimino-buttersaeure-aethylester auf 240grad bis 250grad;
With hydrogenchloride; sulfuric acid; acetic anhydride Multistep reaction;
at 20℃; beim Erhitzen des erhaltenen β-o-Tolylimino-buttersaeure-aethylester auf 240grad bis 250grad;
  • 10
  • [ 13562-88-4 ]
  • [ 95-53-4 ]
  • [ 15644-80-1 ]
YieldReaction ConditionsOperation in experiment
With calcium sulfate at 95 - 100℃; Erhitzen des Reaktionsprodukts in Biphenyl und Diphenylaether auf 250grad-260grad;
  • 11
  • [ 15644-80-1 ]
  • [ 89-98-5 ]
  • 2-[(E)-2-(2-Chloro-phenyl)-vinyl]-8-methyl-quinolin-4-ol [ No CAS ]
YieldReaction ConditionsOperation in experiment
With acetic anhydride for 3h; Heating; Yield given;
  • 12
  • [ 15644-80-1 ]
  • [ 79-04-9 ]
  • [ 80820-20-8 ]
YieldReaction ConditionsOperation in experiment
In benzene for 3h; Heating; Yield given;
  • 13
  • [ 15644-80-1 ]
  • [ 32314-39-9 ]
YieldReaction ConditionsOperation in experiment
With trichlorophosphate at 75℃;
With trichlorophosphate
With trichlorophosphate at 110℃; for 6h; C Step C: 4-Chloro-2,8-dimethylciuinoline 2,8-Dimethylquinolin-4-ol (0.70 g, 4.0 mmol) was suspended in POC13 (7 mL) and the stirred reaction mixture was heated at 110 °C for 6 h, then cooled to ambienttemperature. The reaction mixture was concentrated to remove most of the POC13 and the residue was poured onto ice with stirring. The resulting mixture was adjusted to pH 7 - 8 by addition of saturated aqueous sodium bicarbonate, and the precipitate was isolated by filtration and dried to give the title compound. MS: m/z = 192.0 (M + 1); 1H NMR (400 MHz, CDC13) ö 8.04 (d, 1H, J 8.4 Hz), 7.58 (d, 1H, J 6.8 Hz), 7.45 (m, 1H), 7.39 (s, 1H), 2.80 (s, 3H), 2.73(s, 3H).
With trichlorophosphate In acetonitrile at 110℃; for 6h; C Step C: 4-Chloro-2,8-dimethylquinoline Step C: 4-Chloro-2,8-dimethylquinoline 2,8-Dimethylquinolin-4-ol (0.70 g, 4.0 mmol) was suspended in POCI3 (7 mL) and the stirred reaction mixture was heated at 110 °C for 6 h, then cooled to ambient temperature. The reaction mixture was concentrated to remove most of the POCI3 and the residue was poured onto ice with stirring. The resulting mixture was adjusted to pH 7 - 8 by addition of saturated aqueous sodium bicarbonate, and the precipitate was isolated by filtration and dried to give the title compound. MS: m/z = 192.0 (M + 1); 1H NMR (400 MHz, CDCi3) δ 8.04 (d, 1H, J = 8.4 Hz), 7.58 (d, 1H, J = 6.8 Hz), 7.45 (m, 1H), 7.39 (s, 1H), 2.80 (s, 3H), 2.73 (s, 3H).
With trichlorophosphate for 3h; Reflux;

YieldReaction ConditionsOperation in experiment
o-Toluidin, Acetessigsaeureethylester;
Acetoacet-2-methylanilid, PPA;
o-Toluidin 1. Polyphosphorsaeure, 5 min. 2. Acetessigsaeure-ethylester, 10 min. 3. 140grad, 2 h;
  • 15
  • [ 15644-80-1 ]
  • [ 33513-42-7 ]
  • [ 32314-39-9 ]
  • [ 34550-29-3 ]
  • [ 503552-61-2 ]
YieldReaction ConditionsOperation in experiment
1: 73.5% 2: 18% 3: 5% Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 0 - 5℃; for 1.5h; Stage #2: 2,8-dimethyl-quinolin-4-ol at 100℃; for 12.5h;
1: 73.5% 2: 18% 3: 5% Stage #1: N,N-dimethyl-formamide With trichlorophosphate for 1h; cooling; Stage #2: 2,8-dimethyl-quinolin-4-ol for 12.5h; Heating;
  • 16
  • 3-<i>o</i>-tolylamino-but-2-enoic acid ethyl ester [ No CAS ]
  • [ 15644-80-1 ]
YieldReaction ConditionsOperation in experiment
In diphenylether at 240℃;
In diphenylether at 240℃;
Historical Records

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