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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
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CAS No. : | 1568026-19-6 | MDL No. : | MFCD21645752 |
Formula : | C6H11F2NO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | GLSFKVZLDBCSSQ-YFKPBYRVSA-N |
M.W : | 151.15 | Pubchem ID : | 64115141 |
Synonyms : |
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Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501 | UN#: | 1760 |
Hazard Statements: | H302-H315-H318-H335-H227 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
54% | Stage #1: (S)-1-(2,2-difluoroethyl)pyrrolidin-3-ol; 2-(7-hydroxy-9H-thioxanthen-4-yl)-6-morpholino-4H-pyran-4-one With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 71h; Inert atmosphere; Stage #2: With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; N,N-dimethyl-formamide at 60 - 70℃; for 40h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
260 mg | With triethylamine In dichloromethane at 20℃; for 1.5h; | Intermediate 204: (S)-1-(2,2-difluoroethyl)pyrrolidin-3-yl methanesulfonate Intermediate 204 was isolated as a beige solid (260 mg) according to general procedure 5f, starting from (S)-1-(2,2-difluoroethyl)pyrrolidin-3-ol (100 mg, 0.63 mmol). M/Z (M+H)+: 230.0. General Procedure 5f: electrophile formation - mesylation To a solution of an alcohol (1.0 equiv) in DCM (0.2 M) was added triethylamine (1.1 equiv) and methanesulfonyl chloride (1.1 equiv). The reaction mixture was stirred at rt for 1 h. In case of uncomplete conversion, triethylamine (0.5 equiv) and methanesulfonyl chloride (0.5 equiv) were added and the reaction mixture was stirred at rt for 30 min. The mixture was concentrated to dryness and co-evaporated twice with toluene. The product was further purified when necessary. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane / 1.5 h / 20 °C 2.1: sodium hydride / tetrahydrofuran; mineral oil 2.2: 19 h / 70 °C |