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Chemical Structure| 1578264-17-1 Chemical Structure| 1578264-17-1

Structure of 1578264-17-1

Chemical Structure| 1578264-17-1

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Product Details of [ 1578264-17-1 ]

CAS No. :1578264-17-1
Formula : C9H12IN3O2
M.W : 321.12
SMILES Code : O=C(OC(C)(C)C)NC1=NC=C(I)C=N1
MDL No. :MFCD28405364

Safety of [ 1578264-17-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 1578264-17-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1578264-17-1 ]

[ 1578264-17-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1445-39-2 ]
  • [ 24424-99-5 ]
  • [ 1578264-17-1 ]
YieldReaction ConditionsOperation in experiment
51% With dmap; triethylamine; In tetrahydrofuran; at 60℃; for 12h; The resulting <strong>[1445-39-2]2-amino-5-iodopyrimidine</strong> (1.4 g, 6.33 mmol, 1.0 eq) and triethylamine (1.9 g, 19 mmol, 3.0 eq.) 2as dissolved in 25 ml of tetrahydrofuran, followed by addition of 4-dimethylaminopyridine (DMAP) (0.3 g, 3.2 mmol, 0.5 eq) and dicarbonate di-tert-butyl ester (2.77 g, 12.7 mmol, 2.0 equiv). The reaction was heated to 60 C for 12 hours. After the reaction solution was concentrated under reduced pressure, silica after gel column chromatography to give a brown solid 2-iodo-5-(t-butoxycarbonyl)aminopyrimidine (1.35 g, yield: 51%).
 

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