[ CAS No. 15827-84-6 ]

Name: 15827-84-6|4-Aminonicotinonitrile|96%
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Quality Control of [ 15827-84-6 ]

COA NMR CNMR HPLC LC-MS

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Product Details of [ 15827-84-6 ]

CAS No. :	15827-84-6	MDL No. :	MFCD04035595
Formula :	C₆H₅N₃	Boiling Point :	350°C at 760 mmHg
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	119.12 g/mol	Pubchem ID :	577016
Synonyms :

Safety of [ 15827-84-6 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P270-P304+P340+P312-P362-P332+P313-P261-P271-P280-P264-P301+P312+P330-P305+P351+P338+P310-P501-P302+P352	UN#:	3259
Hazard Statements:	H302-H315-H318-H335	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 15827-84-6 ]

Downstream synthetic route of [ 15827-84-6 ]

[ 15827-84-6 ] Synthesis Path-Downstream 1~22

1
[ 15827-84-6 ]
[ 105-53-3 ]
[ 129395-52-4 ]

Yield	Reaction Conditions	Operation in experiment
40%	With sodium ethanolate for 24h; Heating;

Reference： [1]Dunn, Allan D. [Zeitschrift fur Chemie, 1990, vol. 30, # 1, p. 20 - 21]

2
(E/Z)-N-(2-Cyanovinyl)asparaginsaeuredinitril [ No CAS ]
[ 15827-84-6 ]

Yield	Reaction Conditions	Operation in experiment
31%	With 4 A molecular sieve at 500℃;
31%	With 4 A molecular sieve at 500℃; flash vaccum pyrolysis;

Reference： [1]Xiang, Yi-Bin; Drenkard, Susanne; Baumann, Karl; Hickey, Deirdre; Eschenmoser, Albert [Helvetica Chimica Acta, 1994, vol. 77, # 8, p. 2209 - 2250]
[2]Xiang, Yi-Bin; Drenkard, Susanne; Baumann, Karl; Hickey, Deirdre; Eschenmoser, Albert [Helvetica Chimica Acta, 1994, vol. 77, # 8, p. 2209 - 2250]

Yield	Reaction Conditions	Operation in experiment
	4-Mercapto-pyrido<4.3-d>pyrimidin, ClCH2COOH (in sd. aq. Na2CO3, 20 min);

4
ethyl 2-(6-morpholino-1H-benzo[d]imidazol-2-yl)acetate [ No CAS ]
[ 15827-84-6 ]
4-amino-3-(6-morpholin-4-yl-1<i>H</i>-benzoimidazol-2-yl)-1<i>H</i>-[1,6]naphthyridin-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With lithium hexamethyldisilazane In tetrahydrofuran

Reference： [1]Frazier, Kelly; Jazan, Elisa; McBride, Christopher M.; Pecchi, Sabina; Renhowe, Paul A.; Shafer, Cynthia M.; Taylor, Clarke; Bussiere, Dirksen; He, Molly Min; Jansen, Johanna M.; Lapointe, Gena; Ma, Sylvia; Vora, Jayesh; Wiesmann, Marion [Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 8, p. 2247 - 2251]

5
[ 402948-33-8 ]
[ 15827-84-6 ]
4-amino-3-(5-morpholin-4-yl-1H-benzimidazol-2-yl)-1,6-naphthyridin-2(1H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With ammonium chloride In tetrahydrofuran	11 4-Amino-3-(5-morpholin-4-yl-1H-benzimidazol-2-yl)-1,6-naphthyridin-2(1H)-one Example 11 4-Amino-3-(5-morpholin-4-yl-1H-benzimidazol-2-yl)-1,6-naphthyridin-2(1H)-one LiHMDS (3.3 eq) was added to ethyl (5-morpholin-4-yl-1H-benzimidazol-2-yl)acetate (1.0 eq) and 4-aminopyridine-3-carbonitrile (see J. Chem. Soc. 1967, p1558-1564; 1.0 eq) in THF at 0° C. The reaction was stirred overnight. The resulting mixture was quenched with an aqueous saturated NH4Cl solution and extracted with EtOAc. The combined organic layers were washed with H2O and brine, dried over Na2SO4, filtered, and concentrated in vacuo to yield a brown solid. The crude material was washed successively with CH2Cl2 and MeOH, and then was purified by reverse phase HPLC to provide the desired product. LC/MS m/z 363.2 (MH+), Rt 1.55 minutes.

Reference： [1]Current Patent Assignee: NOVARTIS AG; Novartis (w/o Sandoz) - US2002/103230, 2002, A1

6
[ 42373-30-8 ]
3.5-Chloro-4-cyanopyridine [ No CAS ]
[ 15827-84-6 ]

Yield	Reaction Conditions	Operation in experiment
		(a) 4-Amino-3-cyanopyridine This compound was prepared from <strong>[42373-30-8]4-amino-3-formylpyridine</strong> following the method of Preparation 2(b) to give the product as a white solid. MS (+EI) m/z 119 (M)+; 1H NMR (d6-DMSO) 8.38 (1H, s), 8.12 (1H, d), 7.02 (2H, s), 6.66 (1H, d).

Reference： [1]Patent: US6303613,2001,B1

7
[ 676-58-4 ]
[ 15827-84-6 ]
[ 53277-43-3 ]

Yield	Reaction Conditions	Operation in experiment
	With oxalic acid In tetrahydrofuran	1 1-(4-Amino-3-pyridinyl)ethanone EXAMPLE 1 1-(4-Amino-3-pyridinyl)ethanone To a solution of 17.72 g (4-amino-3-pyridyl)carbonitrile in 400 ml THF (tetrahydrofuran) at 0° C. was added dropwise 200 ml 3.0M methylmagnesium chloride in THF. After the addition was complete, the reaction mixture was allowed to come to room temperature and stirred twenty-four hours. The reaction was quenched with water. Saturated oxalic acid solution (350 ml) was added, and the mixture was then refluxed for one and a half hours. This mixture was made basic with dilute NaOH solution, and extracted with EtOAc. The extracts were washed with saturated NaCl solution, dried (MgSO4), and concentrated to yield 16.14 g solid. Purification of 1.5 g by flash chromatography and recrystallization from toluene yielded 0.71 g solid, m.p. 161°-163° C. ANALYSIS: Calculated for C7 H8 N2 O: 61.75% C; 5.92% H; 20.57% N. Found: 62.09% C; 5.83% H; 20.34% N.

Reference： [1]Current Patent Assignee: SANOFI - US5166170, 1992, A

8
[ 23794-16-3 ]
[ 15827-84-6 ]
[ 1289555-46-9 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 2-bromo-1-(2-chloropyridin-4-yl)ethan-1-one; 4-aminopyridine-3-carbonitrile In ethanol for 2h; Reflux; Stage #2: With sodium hydrogencarbonate In ethanol for 4h; Reflux;	1.3 6-Aminonicotinonitnle (2 g, 16.8 mmoi) and 2-bromo-1-(2-ch]oro-4-yl)-ethanone (3.9 g, 16.8 mmol) were refluxed in ethanol (100 ml) for 2h. Pale-yellow precipitate formed. NaHC03 (2 g) was added to the cooled reaction mixture and the mixture was refluxed for another 4h. After cooling, the precipitate was filtrated, washed with water and recrystalized from ethyl acetate to give the 2-(2-chloropyridin-4-yl)-6-cyano-imidazo[1 ,2-a]pyridine (1.7 g). 1 H NMR (300 MHz, D SO~cf6) δ: 8.70 (d, 1H) 8.30 (d, 1 H) 7.63 (s, 1 H) 7.35 (d, 1H) 7.29 (d, 1 H) 7.21 (dd, 1 H) 7.14 (dd, H) ; MS (ES) miz (M+H) 255.7

Reference： [1]Current Patent Assignee: GUERBET - WO2011/45415, 2011, A2 Location in patent: Page/Page column 41

9
7-bromo-5-chloroquinoxaline [ No CAS ]
[ 15827-84-6 ]
4-[(8-chloroquinoxalin-6-yl)amino]pyridine-3-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
39%	With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane at 120℃; for 3h; Inert atmosphere; Sealed tube;	146 Example 146 4-[(8-chloroquinoxalin-6-yl)amino]pyridine-3-carbonitrile The title compound is prepared according to General Procedure 1 described in Example 1 , using 7-bromo-5-chloroquinoxaline (Intermediate 3, 100 mg; 0.40 mmol; 1 eq.), 4-aminopyridine-3-carbonitrile (65 mg; 0.52 mmol; 1.30 eq.), cesium carbonate (342 mg; 1.04 mmol; 2.60 eq.), BINAP (26 mg; 0.04 mmol; 0.10 eq.) and palladium(ll) acetate (9 mg; 0.04 mmol; 0.10 eq.) in anhydrous dioxane (3 mL). Conditions: 3 hours at 120 °C. Purification by FCC (0% to 100% EtOAc gradient in hexane followed by 0% to 10% MeOH gradient in EtOAc) yields 4-[(8-chloroquinoxalin-6-yl)amino]pyridine-3- carbonitrile (45 mg; 0.16 mmol; 39%; off-white powder; HPLC purity: 97.4%).

Reference： [1]Current Patent Assignee: SELVITA S.A. - WO2016/180537, 2016, A1 Location in patent: Page/Page column 235

10
[ 15827-84-6 ]
[ 98-80-6 ]
[ 3810-12-6 ]

Yield	Reaction Conditions	Operation in experiment
60%	With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate In 2-methyltetrahydrofuran; water at 80℃; for 4h; Inert atmosphere;	7.1 [00200] 3-benzoylpyridin-4-amine (EV-AT1790-001) - Step 1 [00201] To a round-bottomed flask was added 4-aminopyridine-3-carbonitrile (500 mg, 4.2 mmol), phenylboronic acid (1023.6 mg, 8.4 mmol), Pd(TFA)2 (69.8 mg, 0.2 mmol), 5,5'-dimethyl-2,2'-bipyridine (58 mg, 0.3 mmol), methanesulfonic acid, 70% aq (70%, 5762.7 mg, 42 mmol), 2- methyl-THF (10 ml) and water (5 ml). The mixture was heated to 80C under N2 for 4 h. The mixture was cooled to room temperature, neutralized with saturated NaHCCb (aq) and extracted into EtOAc (2 x 30 ml). The combined organics were concentrated in vacuo and the crude yellow oil purified by flash column chromatography (0-20% MeOH in EtOAc) to afford 501 mg (60%) of 3-benzoylpyridin-4-amine (EV-AT1790-001) as a white crystalline solid. LCMS (method B): retention time 1.40min, M/z = 199.2 (M + 1).

Reference： [1]Current Patent Assignee: BRISTOL-MYERS SQUIBB CO - WO2018/49296, 2018, A1 Location in patent: Paragraph 00200-00201

11
[ 15827-84-6 ]
N-(3-(2-chlorobenzoyl)pyridin-4-yl)-4-(2-methoxyphenyl)piperazine-1-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: palladium(II) trifluoroacetate; 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid / 2-methyltetrahydrofuran; water / 36 h / 80 °C 2.1: pyridine; bis(trichloromethyl) carbonate / 1,2-dichloro-ethane / 1 h / 90 °C / Inert atmosphere 2.2: 4 h / Inert atmosphere; Reflux

Reference： [1]Waltemate, Jana; Ivanov, Igor; Ghasemi, Jahan B.; Aghaee, Elham; Daniliuc, Constantin Gabriel; Müller, Klaus; Prinz, Helge [Bioorganic and Medicinal Chemistry Letters, 2021, vol. 32]

12
[ 15827-84-6 ]
N-(3-(2-chlorobenzoyl)pyridin-4-yl)-4-(3-methoxyphenyl)piperazine-1-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: palladium(II) trifluoroacetate; 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid / 2-methyltetrahydrofuran; water / 36 h / 80 °C 2.1: pyridine; bis(trichloromethyl) carbonate / 1,2-dichloro-ethane / 1 h / 90 °C / Inert atmosphere 2.2: 4 h / Inert atmosphere; Reflux

13
[ 15827-84-6 ]
5-(4-(2-methoxyphenyl)piperazine-1-carbonyl)benzo[b][1,6]naphthyridin-10(5H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: palladium(II) trifluoroacetate; 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid / 2-methyltetrahydrofuran; water / 36 h / 80 °C 2.1: pyridine; bis(trichloromethyl) carbonate / 1,2-dichloro-ethane / 1 h / 90 °C / Inert atmosphere 2.2: 4 h / Inert atmosphere; Reflux 3.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 5 h / 115 °C / Inert atmosphere

14
[ 15827-84-6 ]
5-(4-(3-methoxyphenyl)piperazine-1-carbonyl)benzo[b][1,6]naphthyridin-10(5H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: palladium(II) trifluoroacetate; 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid / 2-methyltetrahydrofuran; water / 36 h / 80 °C 2.1: pyridine; bis(trichloromethyl) carbonate / 1,2-dichloro-ethane / 1 h / 90 °C / Inert atmosphere 2.2: 4 h / Inert atmosphere; Reflux 3.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 5 h / 115 °C / Inert atmosphere

15
[ 15827-84-6 ]
[ 244205-40-1 ]
[ 109575-10-2 ]

Yield	Reaction Conditions	Operation in experiment
15%	With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate In 2-methyltetrahydrofuran; water at 80℃; for 36h;	(2-Aminophenyl)(2-chlorophenyl)methanone (3a) General procedure: 2-Aminobenzonitrile (1a, 1.2 g,10 mmol), 2-chlorophenylboronic acid (2a, 3.1 g, 20 mmol), palladium(II) trifluoroacetate(0.17 g, 0.50 mmol), 5,5’-dimethyl-2,2’-bipyridyl (0.19 g, 1.0 mmol) and methanesulfonicacid (9.6 g, 0.1 mol) were suspended in a mixture of 2-methyltetrahydrofuran (15 mL) andH2O (10 mL). The mixture was heated to 80 °C for 36 h under air. After cooling to roomtemperature, the mixture was extracted with ethyl acetate (3 × 30 mL), washed with brine (3 ×30 mL), dried over Na2SO4 and the combined organic layers were concentrated under reducedpressure. The crude product was purified by column chromatography (10% ethylacetate/cyclohexane) to give 3a as a yellow oil (1.5 g, 66%).

16
[ 15827-84-6 ]
4-oxo-4,6-dihydropyrido[4,3-d][1,2,3]triazine 2-oxide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 12 h / 120 °C 2: trifluoroacetic anhydride; nitric acid / -15 °C

Reference： [1]Liu, Yuji; Qi, Xiujuan; Zhang, Wenquan; Yin, Ping; Cai, Ziwu; Zhang, Qinghua [Organic Letters, 2021, vol. 23, # 3, p. 734 - 738]

17
[ 15827-84-6 ]
4-amino-N’-hydroxynicotinimidamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
77%	With hydroxylamine In methanol at 20℃; for 1h;

Reference： [1]Liu, Yuji; Qi, Xiujuan; Zhang, Wenquan; Yin, Ping; Cai, Ziwu; Zhang, Qinghua [Organic Letters, 2021, vol. 23, # 3, p. 734 - 738]

18
[ 15827-84-6 ]
4-aminopyrido[4,3-d][1,2,3]triazine 3-oxide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: hydroxylamine / methanol / 1 h / 20 °C 2: sodium nitrite; hydrogenchloride / water / 0.5 h / -5 °C

Reference： [1]Liu, Yuji; Qi, Xiujuan; Zhang, Wenquan; Yin, Ping; Cai, Ziwu; Zhang, Qinghua [Organic Letters, 2021, vol. 23, # 3, p. 734 - 738]

19
[ 15827-84-6 ]
3-tetrazolylpyridin-4-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%	With sodium azide; ammonium chloride In N,N-dimethyl-formamide at 120℃; for 12h;

Reference： [1]Liu, Yuji; Qi, Xiujuan; Zhang, Wenquan; Yin, Ping; Cai, Ziwu; Zhang, Qinghua [Organic Letters, 2021, vol. 23, # 3, p. 734 - 738]

20
[ 61117-58-6 ]
[ 591-50-4 ]
[ 15827-84-6 ]
N-(3-cyanopyridin-4-yl)benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
66%	With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane at 110℃; Schlenk technique; Inert atmosphere; Sealed tube; chemoselective reaction;

Reference： [1]Cheruku, Srinivas; Sajith, Ayyiliath M.; Narayana, Yatheesh; Shetty, Poornima; Nagarakere, Sandhya C.; Sagar, Kunigal S; Manikyanally, Kumara N.; Rangappa, Kanchugarkoppal Subbegowda; Mantelingu, Kempegowda [Journal of Organic Chemistry, 2021, vol. 86, # 8, p. 5530 - 5537]

21
[ 22996-21-0 ]
[ 15827-84-6 ]
(E)-4-((4-methoxy-2-nitrobenzylidene)amino)nicotinonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	With titanium tetrachloride; triethylamine In tetrahydrofuran; toluene at -78 - -5℃; for 6.75h;

Reference： [1]Prime, Michael E.; Liu, Longbin; Lee, Matt R.; Khetarpal, Vinod; Brown, Christopher J.; Johnson, Peter D.; Miranda-Azpiazu, Patricia; Chen, Xuemei; Clark-Frew, Daniel; Coe, Samuel; Davis, Randall; Dickie, Anthony; Ebneth, Andreas; Esposito, Simone; Gadouleau, Elise; Gai, Xinjie; Galan, Sebastien; Green, Samantha; Greenaway, Catherine; Giles, Paul; Halldin, Christer; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; Heßmann, Manuela; Jia, Zhisheng; Kiselyov, Alexander; Kotey, Adrian; Krulle, Thomas; Mangette, John E.; Marston, Richard W.; Menta, Sergio; Mills, Matthew R.; Monteagudo, Edith; Nag, Sangram; Nibbio, Martina; Orsatti, Laura; Schaertl, Sabine; Scheich, Christoph; Sproston, Joanne; Stepanov, Vladimir; Svedberg, Marie; Takano, Akihiro; Taylor, Malcolm; Thomas, Wayne; Toth, Miklós; Vaidya, Darshan; Vanräs, Katarina; Weddell, Derek; Wigginton, Ian; Wityak, John; Mrzljak, Ladislav; Munoz-Sanjuan, Ignacio; Bard, Jonathan A.; Dominguez, Celia [Journal of Medicinal Chemistry, 2020, vol. 63, # 15, p. 8608 - 8633]

22
[ 22996-21-0 ]
[ 15827-84-6 ]
4-(6-methoxy-2H-indazol-2-yl)nicotinonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: triethylamine; titanium tetrachloride / toluene; tetrahydrofuran / 6.75 h / -78 - -5 °C 2: triethyl phosphite / 2 h / 105 °C

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Ghs Precautionary Statements

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P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 15827-84-6 ]

Quality Control of [ 15827-84-6 ]

Related Doc. of [ 15827-84-6 ]

Product Details of [ 15827-84-6 ]

Safety of [ 15827-84-6 ]

Application In Synthesis of [ 15827-84-6 ]

[ 15827-84-6 ] Synthesis Path-Downstream 1~22

Related Functional Groups of [ 15827-84-6 ]

Nitriles

Amines

Related Parent Nucleus of [ 15827-84-6 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 15827-84-6 ]

Related Parent Nucleus of
[ 15827-84-6 ]