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Chemical Structure| 1584121-99-2 Chemical Structure| 1584121-99-2

Structure of IT-901
CAS No.: 1584121-99-2

Chemical Structure| 1584121-99-2

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IT-901 is an orally active inhibitor of the NF-κB subunit c-Rel with good bioactivity, capable of blocking NF-κB and c-Rel DNA binding, suitable for research on human lymphomas and graft-versus-host disease (GVHD).

Synonyms: IT-901

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Product Details of IT-901

CAS No. :1584121-99-2
Formula : C17H14N2O4S
M.W : 342.37
SMILES Code : O=C(/C(C(N1)=O)=C\C2=C3C=CC=CC3=C(OC)C=C2OC)NC1=S
Synonyms :
IT-901
MDL No. :MFCD30729129

Safety of IT-901

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of IT-901

pyroptosis

Isoform Comparison

Biological Activity

Description
IT-901 is an orally active and potent inhibitor of the NF-κB subunit c-Rel, with IC50 values of 0.1 µM for NF-κB DNA binding and 3 μM for c-Rel DNA binding, respectively. As a bioactive naphthalenethiobarbiturate derivative, IT-901 holds promise for treating human lymphoid tumors and alleviating graft-versus-host disease (GVHD) [1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.92mL

0.58mL

0.29mL

14.60mL

2.92mL

1.46mL

29.21mL

5.84mL

2.92mL

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