Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 15918-80-6 | MDL No. : | MFCD09035713 |
Formula : | C8H10N2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 134.18 | Pubchem ID : | - |
Synonyms : |
|
Signal Word: | Warning | Class: | |
Precautionary Statements: | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 | UN#: | |
Hazard Statements: | H302-H315-H319 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With methanol; nickel; hydrazine hydrate |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In water for 0.5h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
52% | With hydrogenchloride |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Rk. mit Pd/C, Δ -> 5-Amino-indol; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | 21.4 Step 4 Step 4 Preparation of phenylmethyl 2-(1,1-dimethylethyl)-2,3-dihydro-5-[[(phenylmethoxy)carbonyl]amino]-1H-indole-1-carboxylate The nitroindoline from the previous step (9.0 g, 40.9 mmol) is dissolved in a mixture of ethyl acetate (125 ml) and ethanol (125 ml) and hydrogenated at 30 psi in the presence of 10% Pd/C (1.6 g) for 2 hours. Filtration through cellulose and evaporation gave crude 5-aminoindoline (7.77 g, 100%) as a brown oil which is dissolved in THF (180 ml). | |
5-Nitro-indolin, Pd/C, A. (Druckhydr.); |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: 5-amino indoline With sodium hydride In N,N-dimethyl-formamide cooling; Stage #2: bis(phenyl) carbonate In N,N-dimethyl-formamide at 20℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: NaH / dimethylformamide / cooling 1.2: dimethylformamide / 20 °C 2.1: acetonitrile; CHCl3; dimethylformamide / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: acetic acid anhydride; nitric acid / 10 °C / Erhitzen des Reaktionsprodukts mit konz. wss. Salzsaeure 2: N2H4+H2O; Raney nickel; methanol |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: aq.-ethanolic hydrochloric acid 2: N2H4+H2O; Raney nickel; methanol |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
47% | With ammonium formate; trimethylamine In tetrahydrofuran; methanol; dichloromethane; water | R.3 Preparation of N-(2,3-dihydro-1H-indole-5-yl)-methansulfonamide REFERENCE EXAMPLE 3 Preparation of N-(2,3-dihydro-1H-indole-5-yl)-methansulfonamide 5-nitroindoline (100 mg, 0.61 mmol) was dissolved in methanol (2 ml) and tetrahydrofuran (2 ml). Ammonium formate (192 mg, 3.05 mmol, 5 equivalent) and palladium/carbon (10%) in a catalytic amount were added at room temperature and refluxed at 40° C. for ten minutes. After completing the reaction, the reacting solution was filtrated through celite and concentrated under reduced pressure. Afterward, water (5 ml) was added to the residue, extracted consecutively 4 times with ethyl acetate (10 ml), dried over anhydrous magnesium sulfate, concentrated under reduced pressure and then dried completely under a high-degree vacuum. The obtained compound, namely (2,3-dihydro-1H-indole-5-yl)-amine, was dissolved in dichloromethane (5 ml). Then, trimethylamine (0.063 ml, 0.45 mmol) was added to be cooled to -20° C. and mesyl chloride (0.035 ml, 0.45 mmol) was added to be stirred for 30 minutes at the same temperature. Water (5 ml) was added to separate dichloromethane solution, dried over anhydrous magnesium sulfate, purified through a flash column chromatography (an eluent: ethyl acetate/n-hexane=2/1, v/v) and then triturated with isooctane. As a result, the present compound (60 mg, productive yield 47%) was obtained as a white solid. 1H-NMR (400 MHz, DMSO-d6) δ2.00 (s, 3H), 3.15 (t, J=8 Hz, 2H), 3.95 (t, J=8 Hz, 2H), 7.25 (d, J=8 Hz, 1H), 7.45-7.60 (m, 4H), 7.80 (s, 1H), 7.95 (d, J=8 Hz, 1H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | With benzoic acid In toluene at 110℃; for 2h; Inert atmosphere; |