[ CAS No. 15936-09-1 ] {[proInfo.proName]}

Name: 15936-09-1|1,8-Naphthyridin-2(1H)-one|98%
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SKU: A717612
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Quality Control of [ 15936-09-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 15936-09-1 ]

SDS Specification

Alternatived Products of [ 15936-09-1 ]

Product Details of [ 15936-09-1 ]

CAS No. :	15936-09-1	MDL No. :	MFCD08234743
Formula :	C₈H₆N₂O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	ZFRUGZMCGCYBRC-UHFFFAOYSA-N
M.W :	146.15	Pubchem ID :	299643
Synonyms :

Calculated chemistry of [ 15936-09-1 ] Expand+

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	10
Fraction Csp3 :	0.0
Num. rotatable bonds :	0
Num. H-bond acceptors :	2.0
Num. H-bond donors :	1.0
Molar Refractivity :	42.36
TPSA :	45.75 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.77 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.31
Log Po/w (XLOGP3) :	0.6
Log Po/w (WLOGP) :	0.92
Log Po/w (MLOGP) :	1.13
Log Po/w (SILICOS-IT) :	2.12
Consensus Log Po/w :	1.22

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.8
Solubility :	2.33 mg/ml ; 0.016 mol/l
Class :	Very soluble
Log S (Ali) :	-1.13
Solubility :	10.7 mg/ml ; 0.0734 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-3.21
Solubility :	0.0895 mg/ml ; 0.000612 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.47

Safety of [ 15936-09-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 15936-09-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 15936-09-1 ]
Downstream synthetic route of [ 15936-09-1 ]

[ 15936-09-1 ] Synthesis Path-Upstream 1~3

1
[ 15936-09-1 ]
[ 15936-10-4 ]

Yield	Reaction Conditions	Operation in experiment
70%	at 100℃; for 1 h;	Description 92; 2-Chloro-1 8-naphthvridine; Phosphorous oxychloride (86 ml, 924 mmol) was added to 1, 8-naphthyridin-2-one [Journal of Organic Chemistry 1990,55 (15), 4744-50] (9.00 g, 61.6 mmol), and the resulting mixture heated to 100°C for 1 hour. The mixture was cooled and the excess phosphorous oxychloride was removed by evaporation. The residue was taken up in dichloromethane (100 ml) and carefully basified by the addition of sat. NaHCO3. The organic layer was separated and dried over Na2SO4, filtered, and evaporated to give the title compound as a white solid (7 g, 70percent). 1H NMR (400 MHz, CDCl3) 7.50 (1 H, d, J8.4), 7.52 (l H, dd, J8. 1 and 4.3), 8.16 (1 H, d, J- 8. 4), 8. 22 (1 H, dd, J8.1 and 2.0), 9.12 (1 H, dd, J4.3 and 2.0).

Reference： [1] Journal of the American Chemical Society, 2015, vol. 137, # 8, p. 2996 - 3003
[2] Patent: WO2005/47279, 2005, A1, . Location in patent: Page/Page column 50
[3] Patent: WO2016/130968, 2016, A1, . Location in patent: Page/Page column 161

2
[ 15936-09-1 ]
[ 15936-10-4 ]

Reference： [1] Patent: US2013/225552, 2013, A1, . Location in patent: Paragraph 0485

3
[ 141-86-6 ]
[ 102-52-3 ]
[ 15936-09-1 ]
[ 15992-83-3 ]

Reference： [1] New Journal of Chemistry, 2017, vol. 41, # 3, p. 1073 - 1081

[ 15936-09-1 ] Synthesis Path-Downstream 1~17

1
[ 127446-37-1 ]
[ 15936-09-1 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; In water; for 6h;Reflux;	A mixture of tert-butyl 3-hydroxy-3-(2-pivalamidopyridin-3-yl)propanoate (30, 7.21 mmol) and 3N HCl was refluxed for 6 h. The solution was then cooled to room temperature, diluted with water/DCM and neutralized with K2CO3. The aqueous phase was separated and washed with DCM. The organic phase were combined, washed with brine and dried with Na2SO4 to give 31 (81%) without further purification.1H NMR (400 MHz, CDCl3) δ 11.62 (s, 1H), 8.69 (dd, J = 4.8, 1.7 Hz, 1H), 7.91 (dd, J = 7.7, 1.7 Hz, 1H), 7.72 (d, J = 9.5 Hz, 1H), 7.22 (dd, J = 7.7, 4.8 Hz, 1H), 6.75 (d, J = 9.5 Hz, 1H).

Reference： [1]Journal of Organic Chemistry,1990,vol. 55,p. 4744 - 4750
[2]Journal of the American Chemical Society,2015,vol. 137,p. 2996 - 3003
[3]Patent: WO2016/130968,2016,A1 .Location in patent: Page/Page column 161

2
[ 15936-10-4 ]
[ 15936-09-1 ]

Reference： [1]Polish Journal of Chemistry,1981,vol. 55,p. 2429 - 2438

3
[ 15992-83-3 ]
[ 15936-09-1 ]
[ 5174-89-0 ]

Reference： [1]Canadian Journal of Chemistry,2000,vol. 78,p. 950 - 956

4
[ 104830-06-0 ]
[ 15936-09-1 ]

Reference： [1]Chemical and pharmaceutical bulletin,1985,vol. 33,p. 4764 - 4768

5
[ 104830-06-0 ]
[ 292638-85-8 ]
[ 15936-09-1 ]

Yield	Reaction Conditions	Operation in experiment
		In Scheme 91b, pyridine derivative (30) can be converted to the dihydronaphthyridinone (31) in one pot using palladium catalyzed coupling of methylacrylate with (30) in acetonitrile followed by base catalyzed cyclization to [(31).] Hydrogenation to the tetrahydro derivative (32) followed by nitration and subsequent reduction of the nitro functionality with Raney nickel in methanolic ammonia. Compound (33) can be diazotized and converted to the iodo derivative (34) in the presence of t-butylnitrite and copper (I) iodide in refluxing acetonitrile

Reference： [1]Patent: WO2004/14384,2004,A2 .Location in patent: Page/Page column 256; 264

6
[ 15936-09-1 ]
[ 15936-10-4 ]

Yield	Reaction Conditions	Operation in experiment
70%	With trichlorophosphate; at 100℃; for 1.0h;	Description 92; 2-Chloro-1 8-naphthvridine; Phosphorous oxychloride (86 ml, 924 mmol) was added to 1, 8-naphthyridin-2-one [Journal of Organic Chemistry 1990,55 (15), 4744-50] (9.00 g, 61.6 mmol), and the resulting mixture heated to 100C for 1 hour. The mixture was cooled and the excess phosphorous oxychloride was removed by evaporation. The residue was taken up in dichloromethane (100 ml) and carefully basified by the addition of sat. NaHCO3. The organic layer was separated and dried over Na2SO4, filtered, and evaporated to give the title compound as a white solid (7 g, 70%). 1H NMR (400 MHz, CDCl3) 7.50 (1 H, d, J8.4), 7.52 (l H, dd, J8. 1 and 4.3), 8.16 (1 H, d, J- 8. 4), 8. 22 (1 H, dd, J8.1 and 2.0), 9.12 (1 H, dd, J4.3 and 2.0).
	With trichlorophosphate; at 110℃; for 1.5h;	A mixture of 31 (5.78 mmol) in POCl3 (88 mmol) was heated at 110 C for 90 min. The solution was cooled to room temperature, poured into water/DCM mixture and neutralized with NH4OH solution. The aqueous phase was separated and washed with DCM. The organic phase was dried with Na2SO4 and evaporated to give the title compound (75%) which was used in the next step without further purification.1H NMR (500 MHz, DMSO-d6) delta 9.16 (s, 1H), 8.64 (d, J = 8.1 Hz, 1H), 8.52 (d, J = 8.5 Hz, 1H), 7.83- 7.77 (m, 1H), 7.71 (d, J = 8.5 Hz, 1H). HRMS (ESI): calc. for [M+H]+(C8H5N2Cl 165.0220, found 165.0226.

Reference： [1]Journal of the American Chemical Society,2015,vol. 137,p. 2996 - 3003
[2]Patent: WO2005/47279,2005,A1 .Location in patent: Page/Page column 50
[3]Patent: WO2016/130968,2016,A1 .Location in patent: Page/Page column 161

7
[ 15936-09-1 ]
[ 40000-79-1 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogen; acetic acid;palladium 10% on activated carbon; In tetrahydrofuran;	In Scheme 91b, pyridine derivative (30) can be converted to the dihydronaphthyridinone (31) in one pot using palladium catalyzed coupling of methylacrylate with (30) in acetonitrile followed by base catalyzed cyclization to [(31).] Hydrogenation to the tetrahydro derivative (32) followed by nitration and subsequent reduction of the nitro functionality with Raney nickel in methanolic ammonia. Compound (33) can be diazotized and converted to the iodo derivative (34) in the presence of t-butylnitrite and copper (I) iodide in refluxing acetonitrile

Reference： [1]Patent: WO2004/14384,2004,A2 .Location in patent: Page/Page column 256; 264

8
[ 12257-42-0 ]
[ 15936-09-1 ]
[(Rh(C₈H₅N₂O)(C₇H₈))2]*CH₂Cl₂ [ No CAS ]

Reference： [1]Inorganica Chimica Acta,1986,vol. 120,p. 43 - 48

9
ammonium hexafluorophosphate [ No CAS ]
[ 13965-31-6 ]
[ 15936-09-1 ]
cis-[Pt2(μ-1κN(1):2κN(8)-1,8-naphthyridinate-2-one)2(bpy)2](PF6)2 [ No CAS ]

Reference： [1]Inorganica Chimica Acta,1999,vol. 287,p. 72 - 81

10
[ 14871-92-2 ]
lithium perchlorate [ No CAS ]
[ 15936-09-1 ]
cis-[Pd2(μ-1κN(1):2κN(8)-1,8-naphthyridinate-2-one)2(bpy)2](ClO4)2 [ No CAS ]

Reference： [1]Inorganica Chimica Acta,1999,vol. 287,p. 72 - 81

11
[ 12148-71-9 ]
[ 15936-09-1 ]
[Ir(1,8-naphthrydine-2-onate)(1,5-cyclooctadiene)]n [ No CAS ]

Reference： [1]Inorganica Chimica Acta,1996,vol. 250,p. 241 - 264

12
[ 4360-63-8 ]
[ 15936-09-1 ]
[ 959615-78-2 ]

Yield	Reaction Conditions	Operation in experiment
		To a solution of 1.2 g of <strong>[15936-09-1]1,8-naphthyridin-2(1H)-one</strong> in 18 mL of N,N-dimethylformamide, 0.36 g of 60% sodium hydride was added, and the mixture was stirred at 50 to 60C for 7 minutes. Thereto was added 0.94 mL of 2-bromomethyl-1,3-dioxolan, and the mixture was stirred at 95 to 105C for 3 hours. The reaction mixture was cooled to room temperature, water and ethyl acetate were then added thereto, and the organic layer was separated. The aqueous layer was extracted with ethyl acetate and chloroform. The organic layer and the extract were combined, the resultant solution was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel column chromatography using an eluent of hexane:ethyl acetate = 1:1 to obtain 1.2 g of 1-(1,3-dioxolan-2-ylmethyl)-<strong>[15936-09-1]1,8-naphthyridin-2(1H)-one</strong> as a white solid. 1H-NMR (CDCl3) δ: 3.83-3.93 (2H, m), 3.95-4.17 (2H, m), 4.72 (1H, d, J = 5.1 Hz), 5.56 (1H, t, J = 5.1 Hz), 6.72 (1H, d, J = 9.5 Hz), 7.17 (1H, dd, J = 7.6, 4.7 Hz), 7.64 (1H, d, J = 9.5 Hz), 7.86 (1H, dd, J = 7.6, 1.8 Hz), 8.57 (1H, dd, J = 4.7, 1.8 Hz)

Reference： [1]Patent: EP2022793,2009,A1 .Location in patent: Page/Page column 37

13
[ 917833-15-9 ]
[ 15936-09-1 ]
[ 959616-31-0 ]

Yield	Reaction Conditions	Operation in experiment
		To a solution of 0.15 g of <strong>[15936-09-1]1,8-naphthyridin-2(1H)-one</strong> in 2 mL of N,N-dimethylformamide, 45 mg of 60% sodium hydride was added, and the mixture was stirred at 50 to 65C for 1 hour. Thereto was added a solution of 0.44 g of 1-tert-butyl 4-ethyl 4-(3-((methylsulfonyl)oxy)propyl)piperidine-1,4-dicarboxylate in 1.2 mL of N,N-dimethylformamide, and the reaction mixture was stirred at 80 to 90C for 1 hour 30 minutes and cooled to room temperature, and water and ethyl acetate were then added thereto. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layer and the extract were combined, the resultant solution was washed with a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel column chromatography using an eluent of hexane:ethyl acetate = 3:2 to obtain 0.29 g of 1-tert-butyl 4-ethyl 4-(3-(2-oxo-1,8-naphthyridin-1(2H)-yl)propyl)piperidine-1,4-dicarboxylate as a colorless oily substance. 1H-NMR (CDCl3) δ: 1.22 (3H, t, J = 7.1 Hz), 1.32-1.41 (2H, m), 1.44 (9H, s), 1.65-1.72 (4H, m), 2.05-2.11 (2H, m), 2.80-3.00 (2H, m), 3.75-4.00 (2H, m), 4.13 (2H, q, J = 7.1 Hz), 4.43-4.48 (2H, m), 6.72 (1H, d, J = 9.5 Hz), 7.18 (1H, dd, J = 7.7, 4.7 Hz), 7.65 (1H, d, J = 9.5 Hz), 7.88 (1H, dd, J = 7.7, 1.8 Hz), 8.57 (1H, dd, J = 4.7, 1.8 Hz)

Reference： [1]Patent: EP2022793,2009,A1 .Location in patent: Page/Page column 58

14
[ 15936-09-1 ]
[ 15936-10-4 ]

Yield	Reaction Conditions	Operation in experiment
	With trichlorophosphate;Reflux;	1,8-Naphthyridin-2-ol (2.80 g, 19.16 mmol) was suspended in phosphorus oxychloride (100 ml, 1092 mmol) and heated at gentle reflux. The chlorination was followed by LC/MS and once the conversion was complete the reaction was evaporated to dryness and the residue partitioned between water (400 mL) and ethyl acetate (2×400 mL). The aqueous was extracted with additional ethyl acetate (2×400 mL). The combined organic layers were dried with magnesium sulfate and evaporated to dryness under reduced pressure. The crude compound was used without further purification.

Reference： [1]Patent: US2013/225552,2013,A1 .Location in patent: Paragraph 0485

15
[ 15936-09-1 ]
[ 61323-17-9 ]

Reference： [1]New Journal of Chemistry,2017,vol. 41,p. 1073 - 1081

16
[ 141-86-6 ]
[ 102-52-3 ]
[ 15936-09-1 ]
[ 15992-83-3 ]

Reference： [1]New Journal of Chemistry,2017,vol. 41,p. 1073 - 1081

17
[ 15992-83-3 ]
[ 15936-09-1 ]

Reference： [1]Chemical Communications,2017,vol. 53,p. 8886 - 8889

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Isomers

Technical Information

• 1,4-Addition of an Amine to a Conjugated Enone • 1,4-Additions of Organometallic Reagents • Acetal Formation • Acid-Catalyzed α -Halogenation of Ketones • Acyl Group Substitution • Add Hydrogen Cyanide to Aldehydes and Ketones to Produce Alcohols • Alcohol Syntheses from Aldehydes, Ketones and Organometallics • Aldehydes and Ketones Form Hemiacetals Reversibly • Aldehydes May Made by Terminal Alkynes Though Hydroboration-oxidation • Aldol Addition • Aldol Condensation • Alkenes React with Ozone to Produce Carbonyl Compounds • Alkylation of Aldehydes or Ketones • Alkylation of Enolate Ions • Amide Hydrolysis • Amide Hydrolysis • Amides Can Be Converted into Aldehydes • Amines Convert Acyl Chlorides into Amides • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Base-Catalyzed Hydration of α,β -Unsaturated Aldehydes and Ketones • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Chan-Lam Coupling Reaction • Claisen Condensations Produce β-Dicarbonyl Compounds • Claisen Condensations Produce β-Dicarbonyl Compounds • Clemmensen Reduction • Complex Metal Hydride Reductions • Conjugated Enone Takes Part in 1,4-Additions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Cyanohydrins can be Convert to Carbonyl Compounds under Basic Conditions • Decarboxylation of 3-Ketoacids Yields Ketones • Decarboxylation of Substituted Propanedioic • Deoxygenation of the Carbonyl Group • Deprotonation of a Carbonyl Compound at the α -Carbon • Diorganocuprates Convert Acyl Chlorides into Ketones • Dithioacetal Formation • Enamines Can Be Used to Prepare Alkylated Aldehydes • Enol-Keto Equilibration • Enolate Ions Are Protonated to Form ketones • Exclusive 1,4-Addition of a Lithium Organocuprate • Fischer Indole Synthesis • Formation of an Amide from an Amine and a Carboxylic Acid • Formation of an Amide from an Amine and a Carboxylic Acid • Furan Hydrolyzes to Dicarbonyl Compounds • Geminal Diols and Acetals Can Be Hydrolyzed to Carbonyl Compounds • Grignard Reaction • Hantzsch Pyridine Synthesis • Hemiaminal Formation from Amines and Aldehydes or Ketones • Hemiaminal Formation from Amines and Aldehydes or Ketones • Henry Nitroaldol Reaction • HIO4 Oxidatively Degrades Vicinal Diols to Give Carbonyl Derivatives • Hofmann Rearrangement • Horner-Wadsworth-Emmons Reaction • Hydration of the Carbonyl Group • Hydride Reductions • Hydride Reductions of Aldehydes and Ketones to Alcohols • Hydride Reductions of Aldehydes and Ketones to Alcohols • Hydrogenation by Palladium on Carbon Gives the Saturated Carbonyl Compound • Hydrolysis of Imines to Aldehydes and Ketones • Imine Formation from Amines and Aldehydes or Ketones • Isomerization of β, γ -Unsaturated Carbonyl Compounds • Ketone Synthesis from Nitriles • Ketones Undergo Mixed Claisen Reactions to Form β-Dicarbonyl Compounds • Lawesson's Reagent • Leuckart-Wallach Reaction • Lithium Organocuprate may Add to the α ,β -Unsaturated Carbonyl Function in 1,4-Fashion • Mannich Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mercury Ions Catalyze Alkynes to Ketones • Michael Addition • Oxidation of Alcohols to Carbonyl Compounds • Oxidation of Alkyl-substituted Benzenes Gives Aromatic Ketones • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Phenylhydrazone and Phenylosazone Formation • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Pyrroles, Furans, and Thiophenes are Prepared from γ-Dicarbonyl Compounds • Reactions of Aldehydes and Ketones • Reactions of Amines • Reduction of an Amide to an Amine • Reduction of an Amide to an Amine • Reductive Amination • Reductive Amination • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Stobbe Condensation • Strecker Synthesis • Tebbe Olefination • The Acylium Ion Attack Benzene to Form Phenyl Ketones • The Claisen Rearrangement • The Reaction of Alkynyl Anions with Carbonyl Derivatives • The Wittig Reaction • Thiazolium Salt Catalysis in Aldehyde Coupling • Thiazolium Salts Catalyze Aldehyde Coupling • Thiazolium Salts Catalyze Aldehyde Coupling • Ugi Reaction • Use 1,3-dithiane to Prepare of α-Hydroxyketones • Wittig Reaction • Wolff-Kishner Reduction

Historical Records

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[ 15936-09-1 ]

Amides

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[ 15936-09-1 ]

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P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	Inquiry	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ item.pr_usastock ]}		{[ item.pr_chinastock ]}	{[ item.pr_remark ]}

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 15936-09-1 ] {[proInfo.proName]}

Quality Control of [ 15936-09-1 ]

Related Doc. of [ 15936-09-1 ]

Product Details of [ 15936-09-1 ]

Calculated chemistry of [ 15936-09-1 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 15936-09-1 ]

Application In Synthesis of [ 15936-09-1 ]

[ 15936-09-1 ] Synthesis Path-Upstream 1~3

[ 15936-09-1 ] Synthesis Path-Downstream 1~17

Technical Information

Related Functional Groups of [ 15936-09-1 ]

Amides

Related Parent Nucleus of [ 15936-09-1 ]

Naphthyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

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[ 15936-09-1 ]

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[ 15936-09-1 ]