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[ CAS No. 1595078-06-0 ]

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Chemical Structure| 1595078-06-0
Chemical Structure| 1595078-06-0
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Product Details of [ 1595078-06-0 ]

CAS No. :1595078-06-0 MDL No. :MFCD29091175
Formula : C12H15BBrFO2 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :300.96 g/mol Pubchem ID :-
Synonyms :

1. 2-Bromo-6-fluorophenylboronic acid pinacol ester

Safety of [ 1595078-06-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1595078-06-0 ]

  • Downstream synthetic route of [ 1595078-06-0 ]

[ 1595078-06-0 ] Synthesis Path-Downstream   1~4

  • 1
  • (2-bromo-6-fluorophenyl)boronic acid [ No CAS ]
  • [ 76-09-5 ]
  • [ 1595078-06-0 ]
YieldReaction ConditionsOperation in experiment
In diethyl ether at 20℃; for 15h;
  • 2
  • [ 1595078-06-0 ]
  • [ 1595077-80-7 ]
  • [ 90670-32-9 ]
YieldReaction ConditionsOperation in experiment
1: 2% 2: 32% With potassium <i>tert</i>-butylate; bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium(0) In toluene at 100℃; Schlenk technique; Inert atmosphere; Sealed tube; regioselective reaction;
  • 3
  • [ 1595078-06-0 ]
  • C17H24BFO4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% With [nickel(II)dichloride(dimethoxyethane)]; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl-formamide at 20℃; for 16h;
  • 4
  • [ 1595078-06-0 ]
  • C27H31ClFN5O4 [ No CAS ]
  • C33H36F2N6O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With methanesulfonato(2-(di-tert-butylphosphino)-3,6-dimethoxy-2',4',6'-tri-isopropyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II); potassium carbonate; XPhos In water at 100℃; for 16h; Inert atmosphere; 12.1 Step 1: Preparation of compound 12-2 Under nitrogen protection, compound 4-1 (100 mg, 183.82 μmol) and compound 12-1 (80 mg, 292.46 μmol) were dissolved in dioxane (2 mL) and water (0.4 mL), and methanesulfonic acid ( 2-Dicyclohexylphosphino-2',4',6'-tri-isopropyl-1,1'-biphenyl) (2'-amino-1,1'-biphenyl-2-yl) Palladium (20mg, 23.63μmol), 2-dicyclohexylphosphorus-2,4,6-triisopropylbiphenyl (20mg, 41.95μmol) and potassium carbonate (100mg, 723.54μmol) were reacted at 100 and stirred for 16h. The reaction solution was concentrated under reduced pressure, and the crude product was separated and purified by preparative thin-layer chromatography (methanol/dichloromethane (v/v)=0 to 7%) to obtain compound 12-2.
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