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With [nickel(II)dichloride(dimethoxyethane)]; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl-formamide at 20℃; for 16h;
With methanesulfonato(2-(di-tert-butylphosphino)-3,6-dimethoxy-2',4',6'-tri-isopropyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II); potassium carbonate; XPhos In water at 100℃; for 16h; Inert atmosphere;
12.1 Step 1: Preparation of compound 12-2
Under nitrogen protection, compound 4-1 (100 mg, 183.82 μmol) and compound 12-1 (80 mg, 292.46 μmol) were dissolved in dioxane (2 mL) and water (0.4 mL), and methanesulfonic acid ( 2-Dicyclohexylphosphino-2',4',6'-tri-isopropyl-1,1'-biphenyl) (2'-amino-1,1'-biphenyl-2-yl) Palladium (20mg, 23.63μmol), 2-dicyclohexylphosphorus-2,4,6-triisopropylbiphenyl (20mg, 41.95μmol) and potassium carbonate (100mg, 723.54μmol) were reacted at 100 and stirred for 16h. The reaction solution was concentrated under reduced pressure, and the crude product was separated and purified by preparative thin-layer chromatography (methanol/dichloromethane (v/v)=0 to 7%) to obtain compound 12-2.