[ CAS No. 1622848-92-3 ] {[proInfo.proName]}

Name: 1622848-92-3|(S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide|99%
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Quality Control of [ 1622848-92-3 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 1622848-92-3 ]

CAS No. :	1622848-92-3	MDL No. :	MFCD30828708
Formula :	C₂₀H₁₉N₅O₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	LYPAFUINURXJSG-AWEZNQCLSA-N
M.W :	377.40	Pubchem ID :	77108121
Synonyms :		Chemical Name :	(S)-3-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-5-carboxamide

Safety of [ 1622848-92-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 1622848-92-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1622848-92-3 ]

[ 1622848-92-3 ] Synthesis Path-Downstream 1~9

1
[ 958488-72-7 ]
[ 1622854-83-4 ]
[ 1622848-92-3 ]

Yield	Reaction Conditions	Operation in experiment
83%	Stage #1: (S)-3-amino-5-methyl-2,3-dihydrobenzo[b][1,4]oxazepin-4(5H)-one hydrochloride; 5-benzyl-4H-1,2,4-triazole-3-carboxylic acid hydrochloride With N-ethyl-N,N-diisopropylamine In isopropyl alcohol for 0.166667h; Stage #2: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate; isopropyl alcohol at 20℃; for 0.166667h;	12.H Example 12 Method H (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][l,4]oxazepin-3-yl)-4H-l,2,4- triazole-3-carboxamide A mixture of (S)-3-amino-5-methyl-2,3-dihydrobenzo[b][l,4]oxazepin-4(5H)-one, hydrochloride (4.00 g, 16.97 mmol), 5-benzyl-4H-l,2,4-triazole-3-carboxylic acid, hydrochloride (4.97 g, 18.66 mmol) and DIEA (10.37 mL, 59.4 mmol) in isopropanol (150 mL) was stirred vigorously for 10 minutes and then 2,4,6-tripropyl-l,3,5,2,4,6- trioxatriphosphinane 2,4,6-trioxide (T3P) (50% by wt. in EtOAc) (15.15 mL, 25.5 mmol) was added. The mixture was stirred at rt for 10 minutes and then quenched with water and concentrated to remove isopropanol. The resulting crude material is dissolved in EtOAc and washed with 1M HC1, satd. NaHC03 and brine. Organics were concentrated and purified by column chromatography (220 g silica column; 20-90% EtOAc/hexanes, 15 min.; 90%, 15 min.) to give the title compound as a light orange foam (5.37 g, 83%). 1H NMR (MeOH-d4) δ: 7.40 - 7.45 (m, 1H), 7.21 - 7.35 (m, 8H), 5.01 (dd, J = 11.6, 7.6 Hz, 1H), 4.60 (dd, J = 9.9, 7.6 Hz, 1H), 4.41 (dd, J = 11.4, 9.9 Hz, 1H), 4.17 (s, 2H), 3.41 (s, 3H); MS (m/z) 378.3 (M+H+).

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2014/125444, 2014, A1 Location in patent: Page/Page column 131

2
[ 648430-85-7 ]
[ 1622848-92-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: lithium hydroxide / tetrahydrofuran; water / 20 h / 20 °C 1.2: pH Ca_. 2 2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.17 h 2.2: 0.17 h / 20 °C
	Multi-step reaction with 2 steps 1.1: lithium hydroxide; water / tetrahydrofuran / 20 h / 20 °C 1.2: pH Ca_.2 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 15 °C 2.2: 1 h / 15 - 20 °C

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2014/125444, 2014, A1
[2]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2018/7973, 2018, A2

3
[ 937-39-3 ]
[ 1622848-92-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1.1: ethanol; diethyl ether / 4 h / 20 °C 2.1: 5,5-dimethyl-1,3-cyclohexadiene / 24 h / 170 °C / Dean-Stark 3.1: lithium hydroxide / tetrahydrofuran; water / 20 h / 20 °C 3.2: pH Ca_. 2 4.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.17 h 4.2: 0.17 h / 20 °C
	Multi-step reaction with 4 steps 1.1: ethanol; diethyl ether / 4 h / 20 °C 2.1: 5,5-dimethyl-1,3-cyclohexadiene / 24 h / 170 °C / Dean-Stark 3.1: lithium hydroxide; water / tetrahydrofuran / 20 h / 20 °C 3.2: pH Ca_.2 4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 15 °C 4.2: 1 h / 15 - 20 °C

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2014/125444, 2014, A1
[2]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2018/7973, 2018, A2

4
[ 107469-64-7 ]
[ 1622848-92-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: 5,5-dimethyl-1,3-cyclohexadiene / 24 h / 170 °C / Dean-Stark 2.1: lithium hydroxide / tetrahydrofuran; water / 20 h / 20 °C 2.2: pH Ca_. 2 3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.17 h 3.2: 0.17 h / 20 °C
	Multi-step reaction with 3 steps 1.1: 5,5-dimethyl-1,3-cyclohexadiene / 24 h / 170 °C / Dean-Stark 2.1: lithium hydroxide; water / tetrahydrofuran / 20 h / 20 °C 2.2: pH Ca_.2 3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 15 °C 3.2: 1 h / 15 - 20 °C

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2014/125444, 2014, A1
[2]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2018/7973, 2018, A2

5
[ 889460-62-2 ]
[ 107469-72-7 ]
[ 1622848-92-3 ]

Yield	Reaction Conditions	Operation in experiment
80%	With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere;

Reference： [1]Harris, Philip A.; Berger, Scott B.; Jeong, Jae U.; Nagilla, Rakesh; Bandyopadhyay, Deepak; Campobasso, Nino; Capriotti, Carol A.; Cox, Julie A.; Dare, Lauren; Dong, Xiaoyang; Eidam, Patrick M.; Finger, Joshua N.; Hoffman, Sandra J.; Kang, James; Kasparcova, Viera; King, Bryan W.; Lehr, Ruth; Lan, Yunfeng; Leister, Lara K.; Lich, John D.; MacDonald, Thomas T.; Miller, Nathan A.; Ouellette, Michael T.; Pao, Christina S.; Rahman, Attiq; Reilly, Michael A.; Rendina, Alan R.; Rivera, Elizabeth J.; Schaeffer, Michelle C.; Sehon, Clark A.; Singhaus, Robert R.; Sun, Helen H.; Swift, Barbara A.; Totoritis, Rachel D.; Vossenkämper, Anna; Ward, Paris; Wisnoski, David D.; Zhang, Daohua; Marquis, Robert W.; Gough, Peter J.; Bertin, John [Journal of Medicinal Chemistry, 2017, vol. 60, # 4, p. 1247 - 1261]

6
[ 1622848-92-3 ]
[ 106-93-4 ]
[ 2095514-82-0 ]

Yield	Reaction Conditions	Operation in experiment
11 mg	With sodium hydride In N,N-dimethyl-formamide at 60℃; for 24h;	8 (3S)-3-(2-benzyl-8-oxo-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-5-methyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one Example 8 (3S)-3-(2-benzyl-8-oxo-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-5-methyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one To a solution of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide (47 mg) and sodium hydride (60%, 11 mg) in DMF (1 mL) was added 1,2-dibromoethane (0.013 mL), and the mixture was stirred at 60°C for 24 hr. The residue was purified by silica gel column chromatography (methanol/ethyl acetate), and the obtained mixture was purified again by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (11 mg). 1H NMR (300 MHz, CDCl3) δ 3.38 (3H, s), 3.82 (1H, ddd, J = 12.4, 11.0, 4.2 Hz), 4.06-4.18 (2H, m), 4.34-4.80 (5H, m), 5.82 (1H, dd, J = 11.7, 8.3 Hz), 7.14-7.40 (9H, m).

Reference： [1]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - EP3366684, 2018, A1 Location in patent: Paragraph 0411

7
[ 627-31-6 ]
[ 1622848-92-3 ]
[ 2095514-76-2 ]

Yield	Reaction Conditions	Operation in experiment
2 mg	With sodium hydride In N,N-dimethyl-formamide at 60℃; for 24h;	2 (3S)-3-(2-benzyl-9-oxo-6,7-dihydro-5H-[1,2,4]triazolo[1,5-a][1,4]diazepin-8(9H)-yl)-5-methyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one Example 2 (3S)-3-(2-benzyl-9-oxo-6,7-dihydro-5H-[1,2,4]triazolo[1,5-a][1,4]diazepin-8(9H)-yl)-5-methyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one To a solution of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide (99 mg) and sodium hydride (60 %, 23 mg) in DMF (1 mL) was added 1,3-diiodopropane (0.036 mL), and the mixture was stirred at 60°C for 24 hr. The reaction mixture was purified by silica gel column chromatography (methanol/ethyl acetate), and then silica gel column chromatography (ethyl acetate/hexane). The residue was subjected to preparative HPLC (C18, mobile phase: water/acetonitrile (containing 0.1% TFA)), and the obtained fraction was concentrated under reduced pressure. To the residue was added saturated aqueous sodium hydrogencarbonate solution, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (2 mg). 1H NMR (300 MHz, CDCl3) δ 2.09-2.30 (1H, m), 2.69-2.93 (1H, m), 3.39 (3H, s), 3.41-3.58 (1H, m), 3.77 (1H, dt, J = 15.2, 5.8 Hz), 4.00-4.18 (2H, m), 4.32-4.62 (4H, m), 5.77 (1H, dd, J = 11.5, 8.1 Hz), 7.07-7.44 (9H, m).

Reference： [1]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - EP3366684, 2018, A1 Location in patent: Paragraph 0398

8
[ 958488-72-7 ]
[ 1622854-83-4 ]
[ 1622848-92-3 ]

Yield	Reaction Conditions	Operation in experiment
72%	Stage #1: (S)-3-amino-5-methyl-2,3-dihydrobenzo[b][1,4]oxazepin-4(5H)-one hydrochloride; 5-benzyl-4H-1,2,4-triazole-3-carboxylic acid hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 15℃; for 0.166667h; Stage #2: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; ethyl acetate at 15 - 20℃; for 1h;	16 (-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b] [l,4]oxazepin-3-yl)-4H- l,2,4-triazole-3-carboxamide To a solution of (5)-3-amino-5-methyl-2,3-dihydrobenzo[b][l,4]oxazepin-4(5H)- one hydrochloride (100 g, 437 mmol), 5-benzyl-4H-l,2,4-triazole-3-carboxylic acid hydrochloride (110 g, 459 mmol) in DCM (2.5 L) was added DIPEA (0.267 L, 1531 mmol) at 15 °C. The reaction mixture was stirred for 10 min. and 2,4,6-tripropyl- 1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide >50 wt. % in EtOAc (0.390 L, 656 mmol) was slowly added at 15 °C. After stirring for 60 mins at RT the LCMS showed the reaction was complete, upon which time it was quenched with water, partitioned between DCM and washed with 0.5N HC1 aq (2 L), saturated aqueous NaHCC (2 L), brine (2 L) and water (2 L). The organic phase was separated and activated charcoal (100 g) and Na2S04 (200 g) were added. The dark solution was shaken for 1 h before filtering. The filtrate was then concentrated under reduced pressure to afford the product as a tan foam (120 g). The product was dried under a high vacuum at 50 °C for 16 h. NMR showed 4-5% wt of ethyl acetate present. The sample was dissolved in EtOH (650 ml) and stirred for 30 mins, after which the solvent was removed using a rotavapor (water-bath T=45 °C). The product was dried under high vacuum for 16 h at RT (118 g, 72% yield). The product was further dried under high vacuum at 50 °C for 5 h. NMR showed <1% of EtOH and no ethyl acetate. NMR (400 MHz, DMSO- e) δ ppm 4.12 (s, 2 H), 4.31 - 4.51 (m, 1 H), 4.60 (t, J=10.36 Hz, 1 H), 4.83 (dt, J=l 1.31, 7.86 Hz, 1 H), 7.12 - 7.42 (m, 8 H), 7.42 - 7.65 (m, 1 H), 8.45 (br. s., 1 H), 14.41 (br. s., 1 H). MS (m/z) 378 (M + H+).

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2018/7973, 2018, A2 Location in patent: Page/Page column 66

9
[ 75-75-2 ]
[ 1622848-92-3 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
87.9%	In acetone at 35 - 50℃; for 3.5h;	3; 2 EXAMPLE 3: Large scale preparation of the methane sulfonic acid (MSA) salt of ,S')-5- benzyl-7V-(5-methyl-4-oxo-2. 3.4.5-tetrahvdrobenzo\|/? II 1.4 \|oazepin-3-yl)-4T/- 1. 2.4- triazole-3 -carboxamide (Compound B) (5)-5-benzyl-A-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[6][l,4]oxazepin-3-yl)-477- 1,2,4- triazole-3 -carboxamide (Compound A) (9.98 g) was charged to a vessel with 50 ml (5 vol_eq.) acetone. The mixture was heated to 50 °C, under stirring, for 30 min to achieve full dissolution. Separately, methane sulfonic acid (MSA) (8.1 g, 3.18 mol_eq) was mixed with 30 ml (3 vol_eq.) acetone in a reactor until full dissolution was achieved. The first solution containing Compound A was cooled in acetone to 35 °C for 10 min. 3.4 ml (0.34 vol_eq) of the MSA in acetone solution (containing 0.315 mol_eq. of MSA) was subsequently added to the solution of Compound A /acetone. Then 0.3 g (3 w/w %) of ground crystals of the methane sulfonic acid (MSA) salt of (iS)-5-benzyl-/V-(5-methyl-4- oxo-2, 3.4.5-tetrahydrobenzo\| > \|\| 1 4 \|oxazcpin-3-yl)-4 /- 1. 2, 4-triazole-3 -carboxamide (Compound B) as seeds was also added. The resultant suspension was left to age under stirring for 60 min at 35°C. After the agering was complete, an additional 8 ml (0.8 vol_eq) of the solution of MSA in acetone (Containing 0.744 mol_eq. of MSA) was added to the solution of Compound A/acetone over the course of 120 min while keeping the suspension temperature at 35°C. The resultant suspension was left to age for 30 min at 35°C then it was cooled to 10 °C over 30 min. The resultant suspension was then left to age for a further 10 min then it was filtered under vacuum. The filter cake was dried in a vacuum at 50°C until a constant weight was achieved to provide Compound B in a 87.9% yield as a crystalline solid. NMR (400 MHz, CHLOROFORM-ri) d ppm 2.92 (s, 3 H) 3.39 (s, 3 H) 4.39 (s, 2 H) 4.42 - 4.57 (m, 2 H) 5.07 (dt, J= 1.22, 7.98 Hz, 1 H) 7.13 - 7.30 (m, 7 H) 7.30 - 7.39 (m, 2 H) 8.83 (d, J=8. l2 Hz, 1 H) (±0.2 ppm). (0263) Compound B as obtained by the large scale preparation had a DSC trace substantially the same as Compound B as obtained by the small scale preparation as shown on the DSC overlay in Figure 6. (0264) The unique and novel crystallinity of (Compound B) was confirmed by X-ray powder diffraction analysis (XRPD) which was conducted using a PANanalytical X’Pert Pro diffractometer equipped with a copper anode X-ray tube, programmable slits, and (0265) X’Celerator detector fitted with a nickel filter. Generator tension and current were set to 45kV and 40mA respectively to generate the copper Ka radiation powder diffraction pattern over the range of at least 2 - 40°2Q. The test specimen was lightly triturated using an agate mortar and pestle and the resulting fine powder was mounted onto a silicon zero background plate. The XRPD pattern is shown in Fig. 4 and the peaks are listed below in Table 1.

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2019/123219, 2019, A1 Location in patent: Page/Page column 48-50

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P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 1622848-92-3 ] {[proInfo.proName]}

Quality Control of [ 1622848-92-3 ]

Related Doc. of [ 1622848-92-3 ]

Product Details of [ 1622848-92-3 ]

Safety of [ 1622848-92-3 ]

Application In Synthesis of [ 1622848-92-3 ]

[ 1622848-92-3 ] Synthesis Path-Downstream 1~9

Related Functional Groups of [ 1622848-92-3 ]

Aryls

Amides

Amines

Related Parent Nucleus of [ 1622848-92-3 ]

Triazoles

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 1622848-92-3 ]

Related Parent Nucleus of
[ 1622848-92-3 ]