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Chemical Structure| 1639220-17-9 Chemical Structure| 1639220-17-9

Structure of Sigma-1 receptor antagonist 3
CAS No.: 1639220-17-9

Chemical Structure| 1639220-17-9

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Sigma-1 receptor antagonist 3 is an effective Sigma-1 receptor antagonist with a Ki of 1.14 nM, showing potential for neuropathic pain research.

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Product Details of Sigma-1 receptor antagonist 3

CAS No. :1639220-17-9
Formula : C19H23ClFN3O
M.W : 363.86
SMILES Code : CC1=NC(C2=CC=C(F)C=C2)=NC(OCCCN3CCCCC3)=C1Cl
InChI Key :OAIHSWLLDNASTO-UHFFFAOYSA-N
Pubchem ID :118723363

Safety of Sigma-1 receptor antagonist 3

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of Sigma-1 receptor antagonist 3

GPCR

Isoform Comparison

Biological Activity

Description
Sigma-1 receptor antagonist 3, a potent and selective antagonist of the Sigma-1 (σ1) receptor, exhibits a dissociation constant (Ki) of 1.14 nM. It also inhibits the Human Ether-a-go-go-Related Gene (hERG) channel with an IC50 of 1.54 μM, indicating potential for neuropathic pain treatment[1].

Protocol

Bio Calculators
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2.75mL

0.55mL

0.27mL

13.74mL

2.75mL

1.37mL

27.48mL

5.50mL

2.75mL

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