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Chemical Structure| 1642297-01-5 Chemical Structure| 1642297-01-5

Structure of GDC-0927
CAS No.: 1642297-01-5

Chemical Structure| 1642297-01-5

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GDC-0927, also known as SRN-927, is a next-generation oral SERD, appears to have greater potential than GDC-0810 to be a best-in-class SERD molecule.

Synonyms: SRN-927

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Product Details of GDC-0927

CAS No. :1642297-01-5
Formula : C28H28FNO4
M.W : 461.52
SMILES Code : OC1=CC=C2C(C(C)=C(C3=CC=CC(O)=C3)[C@H](C4=CC=C(OCCN5CC(CF)C5)C=C4)O2)=C1
Synonyms :
SRN-927
MDL No. :MFCD31631581
InChI Key :KJAAPZIFCQQQKX-NDEPHWFRSA-N
Pubchem ID :87055263

Safety of GDC-0927

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02316509 Breast Cancer Phase 1 Active, not recruiting November 30, 2019 United States, Massachusetts ... More >> Massachusetts General Hospital. Boston, Massachusetts, United States, 02114 Dana Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Stony Brook University Medical Center Stony Brook, New York, United States, 11794 United States, Tennessee Sarah Cannon Cancer Center Germantown, Tennessee, United States, 38138 Vanderbilt Ingram Cancer Ctr Nashville, Tennessee, United States, 37232 Spain ICO I Hospitalet Hospital Duran i Reynals Instituto Catalan de Oncologia de Hospitalet ICO L'Hospitalet de Llobregat, Barcelona, Spain, 08908 Onkologikoa - Kutxaren Institutu Onkologikoa San Sebastian, Guipuzcoa, Spain, 20014 Hospital Univ Vall d'Hebron; Servicio de Oncologia Barcelona, Spain, 08035 MD Anderson Cancer Center Madrid - España; Servicio de Farmacia Madrid, Spain, 28033 Hospital Universitario Ramón y Cajal Madrid, Spain, 28034 Hospital General Universitario Gregorio Maranon Madrid, Spain, 28040 HM Sanchinarro - CIOCC Madrid, Spain, 28050 Hospital Clinico Universitario de Valencia Valencia, Spain, 46010 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.83mL

2.17mL

1.08mL

21.67mL

4.33mL

2.17mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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