Structure of Iptacopan
CAS No.: 1644670-37-0
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Iptacopan is a pioneering, efficient, orally active factor B inhibitor with an IC50 of 10 nM and a KD of 7.9 nM. It directly and reversibly binds to factor B, targeting the root cause of C3 glomerulopathy, demonstrating substantial therapeutic potential for such diseases.
Synonyms: LNP023
4.5
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 1644670-37-0 |
Formula : | C25H30N2O4 |
M.W : | 422.52 |
SMILES Code : | [H][C@@]1(C2=CC=C(C(O)=O)C=C2)C[C@@H](OCC)CCN1CC3=C4C=CNC4=C(C)C=C3OC |
Synonyms : |
LNP023
|
MDL No. : | MFCD32174282 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319 |
Precautionary Statements: | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT05222412 | C3 Glomerulopathy (C3G)|Paroxy... More >>smal Nocturnal Hemoglobinuria (PNH) Less << | AVAILABLE | - | - | |
NCT03955445 | C3 Glomerulopathy|Idiopathic I... More >>mmune-complex-membranoproliferative Glomerulonephritis Less << | PHASE3 | RECRUITING | 2033-04-20 | Georgia Nephrology Research In... More >>st, Lawrenceville, Georgia, 30046, United States|University of Iowa Health Care, Iowa City, Iowa, 52242-1091, United States|Col Uni Med Center New York Presby, New York, New York, 10032, United States|Novartis Investigative Site, Buenos Aires, W3400ABH, Argentina|Novartis Investigative Site, Sao Paulo, SP, 04038-002, Brazil|Novartis Investigative Site, Toronto, Ontario, M5G 2C4, Canada|Novartis Investigative Site, Beijing, 100034, China|Novartis Investigative Site, Shanghai, 200040, China|Novartis Investigative Site, Praha, 12808, Czechia|Novartis Investigative Site, Montpellier Cedex 5, 34295, France|Novartis Investigative Site, Paris 15, 75015, France|Novartis Investigative Site, Paris, 75015, France|Novartis Investigative Site, Erlangen, 91054, Germany|Novartis Investigative Site, Essen, 45147, Germany|Novartis Investigative Site, Hamburg, 20246, Germany|Novartis Investigative Site, Heraklion Crete, 71110, Greece|Novartis Investigative Site, Petach Tikva, 49202, Israel|Novartis Investigative Site, Petach Tikva, 4941492, Israel|Novartis Investigative Site, Ranica, BG, 24020, Italy|Novartis Investigative Site, Roma, RM, 00165, Italy|Novartis Investigative Site, Nagoya, Aichi, 466 8560, Japan|Novartis Investigative Site, Asahikawa, Hokkaido, 078 8510, Japan|Novartis Investigative Site, Sapporo, Hokkaido, 060-8543, Japan|Novartis Investigative Site, Takatsuki, Osaka, 569 1192, Japan|Novartis Investigative Site, Niigata, 951 8520, Japan|Novartis Investigative Site, Leiden, Zuid Holland, 2333 ZA, Netherlands|Novartis Investigative Site, Sevilla, Andalucia, 41009, Spain|Novartis Investigative Site, Barcelona, Catalunya, 08035, Spain|Novartis Investigative Site, Pamplona, Navarra, 31008, Spain|Novartis Investigative Site, Madrid, 28040, Spain|Novartis Investigative Site, Madrid, 28041, Spain|Novartis Investigative Site, Bern, 3010, Switzerland|Novartis Investigative Site, Ankara, 06500, Turkey|Novartis Investigative Site, Talas Kayseri, 38039, Turkey|Novartis Investigative Site, London, W12 0HS, United Kingdom|Novartis Investigative Site, Newcastle upon Tyne, NE7 7DN, United Kingdom Less << |
NCT04557462 | Primary IgA Nephropathy | PHASE3 | RECRUITING | 2032-10-28 | AZ Kidney Dise and Hypertensio... More >>n Ctr, Glendale, Arizona, 85306, United States|Kaiser Permanente, San Diego, California, 92111, United States|North America Research Institute, San Dimas, California, 91773, United States|University of Colorado Anschutz, Aurora, Colorado, 80045, United States|Nephrology Associates PA, Newark, Delaware, 19713, United States|CaRe Research, Chubbuck, Idaho, 83202, United States|Brigham and Womens Hosp Harvard Med School, Boston, Massachusetts, 02115, United States|Clinical Research Consultants LLC, Kansas City, Missouri, 64111, United States|DaVita Clinical Research, Las Vegas, Nevada, 89146, United States|Prolato Clinical Research Center, Houston, Texas, 77054, United States|Novartis Investigative Site, Ciudad Autonoma de Buenos Aire, 1426, Argentina|Novartis Investigative Site, Cordoba, X5016KET, Argentina|Novartis Investigative Site, Santa Fe, S3000EPV, Argentina|Novartis Investigative Site, Woolloongabba, Queensland, 4102, Australia|Novartis Investigative Site, Adelaide, South Australia, 5000, Australia|Novartis Investigative Site, Parkville, Victoria, 3065, Australia|Novartis Investigative Site, Edegem, 2650, Belgium|Novartis Investigative Site, Leuven, 3000, Belgium|Novartis Investigative Site, Roeselare, 8800, Belgium|Novartis Investigative Site, Curitiba, PR, 80440-020, Brazil|Novartis Investigative Site, Porto Alegre, RS, 90020-090, Brazil|Novartis Investigative Site, Sao Paulo, SP, 04038-002, Brazil|Novartis Investigative Site, Sao Paulo, SP, 05403 000, Brazil|Novartis Investigative Site, Sao Jose do Rio Preto, 15090 000, Brazil|Novartis Investigative Site, Oshawa, Ontario, L1G 2B9, Canada|Novartis Investigative Site, Guangzhou, Guangdong, 510080, China|Novartis Investigative Site, Changchun, Jilin, 130041, China|Novartis Investigative Site, Yinchuan, Ningxia, 100039, China|Novartis Investigative Site, Taiyuan, Shanxi, 030001, China|Novartis Investigative Site, Wenzhou, Zhejiang, 325000, China|Novartis Investigative Site, Beijing, 100029, China|Novartis Investigative Site, Beijing, 100034, China|Novartis Investigative Site, Guang Zhou, 510080, China|Novartis Investigative Site, Qingdao, 266000, China|Novartis Investigative Site, Shanghai, 200025, China|Novartis Investigative Site, Shanghai, 200040, China|Novartis Investigative Site, Shanxi, 710063, China|Novartis Investigative Site, Shenzhen, 518036, China|Novartis Investigative Site, Medellin, Antioquia, 050001, Colombia|Novartis Investigative Site, Praha, 12808, Czechia|Novartis Investigative Site, Aalborg, 9000, Denmark|Novartis Investigative Site, Arhus N, DK-8200, Denmark|Novartis Investigative Site, Copenhagen, DK-2100, Denmark|Novartis Investigative Site, Odense C, 5000, Denmark|Novartis Investigative Site, Marseille, 13385, France|Novartis Investigative Site, Paris, 75015, France|Novartis Investigative Site, Aachen, 52074, Germany|Novartis Investigative Site, Berlin, 13353, Germany|Novartis Investigative Site, Freiburg, 79106, Germany|Novartis Investigative Site, Heidelberg, 69120, Germany|Novartis Investigative Site, Magdeburg, 39120, Germany|Novartis Investigative Site, Mainz, 55131, Germany|Novartis Investigative Site, Tuebingen, 72076, Germany|Novartis Investigative Site, Ulm, 89081, Germany|Novartis Investigative Site, Pokfulam, Hong Kong|Novartis Investigative Site, Debrecen, 4032, Hungary|Novartis Investigative Site, Bangalore, Karnataka, 560004, India|Novartis Investigative Site, New Delhi, 110029, India|Novartis Investigative Site, Ashkelon, 78278, Israel|Novartis Investigative Site, Jerusalem, 9112001, Israel|Novartis Investigative Site, Petach Tikva, 4941492, Israel|Novartis Investigative Site, Napoli, 80131, Italy|Novartis Investigative Site, Kasugai, Aichi, 486-8510, Japan|Novartis Investigative Site, Toyoake city, Aichi, 470 1192, Japan|Novartis Investigative Site, Toyota, Aichi, 471-8513, Japan|Novartis Investigative Site, Sapporo-city, Hokkaido, 006-8555, Japan|Novartis Investigative Site, Sapporo, Hokkaido, 060-8604, Japan|Novartis Investigative Site, Kawasaki, Kanagawa, 213-8587, Japan|Novartis Investigative Site, Yokohama-city, Kanagawa, 236-0004, Japan|Novartis Investigative Site, Yokohama, Kanagawa, 224-8503, Japan|Novartis Investigative Site, Sendai, Miyagi, 981-3205, Japan|Novartis Investigative Site, Matsumoto, Nagano, 390-8621, Japan|Novartis Investigative Site, Okayama-city, Okayama, 700-8558, Japan|Novartis Investigative Site, Omihachiman, Shiga, 523-0082, Japan|Novartis Investigative Site, Chiba, 260-8712, Japan|Novartis Investigative Site, Kyoto, 605-0981, Japan|Novartis Investigative Site, Osaka, 530-0012, Japan|Novartis Investigative Site, Osaka, 530-8480, Japan|Novartis Investigative Site, Osaka, 534-0021, Japan|Novartis Investigative Site, Cheongju si, Chungcheongbuk Do, 28644, Korea, Republic of|Novartis Investigative Site, Seoul, Korea, 03312, Korea, Republic of|Novartis Investigative Site, Seoul, Seocho Gu, 06591, Korea, Republic of|Novartis Investigative Site, Busan, 47392, Korea, Republic of|Novartis Investigative Site, Seoul, 02841, Korea, Republic of|Novartis Investigative Site, Seoul, 03080, Korea, Republic of|Novartis Investigative Site, Seoul, 03722, Korea, Republic of|Novartis Investigative Site, Seoul, 06973, Korea, Republic of|Novartis Investigative Site, Seoul, 134 727, Korea, Republic of|Novartis Investigative Site, Taegu, 41944, Korea, Republic of|Novartis Investigative Site, Kuala Lumpur, Wilayah Persekutuan, 50586, Malaysia|Novartis Investigative Site, Kuala Lumpur, 59100, Malaysia|Novartis Investigative Site, Queretaro, 76000, Mexico|Novartis Investigative Site, Groningen, 9713 GZ, Netherlands|Novartis Investigative Site, Nordbyhagen, Oslo, 1478, Norway|Novartis Investigative Site, Bergen, NO-5021, Norway|Novartis Investigative Site, Rostov On Don, 344022, Russian Federation|Novartis Investigative Site, St Petersburg, 197110, Russian Federation|Novartis Investigative Site, Singapore, 169608, Singapore|Novartis Investigative Site, Kosice, 04011, Slovakia|Novartis Investigative Site, Ljubljana, 1000, Slovenia|Novartis Investigative Site, Stockholm, 141 86, Sweden|Novartis Investigative Site, Kaohsiung, 83301, Taiwan|Novartis Investigative Site, New Taipei City, 23561, Taiwan|Novartis Investigative Site, New Taipei, 22060, Taiwan|Novartis Investigative Site, Taichung, 40447, Taiwan|Novartis Investigative Site, Taichung, 407219, Taiwan|Novartis Investigative Site, Taipei, 10002, Taiwan|Novartis Investigative Site, Taoyuan, 33305, Taiwan|Novartis Investigative Site, Bangkok, 10330, Thailand|Novartis Investigative Site, Bangkok, 10400, Thailand|Novartis Investigative Site, Istanbul, TUR, 34098, Turkey|Novartis Investigative Site, Istanbul, 34371, Turkey|Novartis Investigative Site, Kocaeli, 41380, Turkey|Novartis Investigative Site, Mersin, 33110, Turkey|Novartis Investigative Site, Talas Kayseri, 38039, Turkey|Novartis Investigative Site, Cambridge, CB2 0QQ, United Kingdom|Novartis Investigative Site, Leicester, LE5 4PW, United Kingdom|Novartis Investigative Site, London, SE5 9RS, United Kingdom|Novartis Investigative Site, Newcastle upon Tyne, NE7 7DN, United Kingdom|Novartis Investigative Site, Salford, M6 8HD, United Kingdom|Novartis Investigative Site, Ho Chi Minh, VNM, 700000, Vietnam Less << |
NCT06797518 | Glomerulonephritis, IGA|Immuno... More >>globulin A Nephropathy Less << | PHASE2 | NOT_YET_RECRUITING | 2028-01-20 | - |
NCT03896152 | Paroxysmal Nocturnal Hemoglobi... More >>nuria Less << | PHASE2 | COMPLETED | 2022-02-09 | Novartis Investigative Site, S... More >>eoul, 03080, Korea, Republic of|Novartis Investigative Site, Seoul, 06351, Korea, Republic of|Novartis Investigative Site, Kota Kinabalu, Sabah, 88586, Malaysia|Novartis Investigative Site, Singapore, 119228, Singapore|Novartis Investigative Site, Taipei, 10002, Taiwan Less << |
NCT04747613 | Paroxysmal Nocturnal Hemoglobi... More >>nuria Less << | PHASE3 | ACTIVE_NOT_RECRUITING | 2027-10-19 | City Of Hope, Duarte, Californ... More >>ia, 91010, United States|USC Norris Cancer Center, Los Angeles, California, 90033, United States|Univ of California Irvine (Chao Family Comprehensive Cancer Center), Orange, California, 92868, United States|Lakes Research, Miami Lakes, Florida, 33014, United States|Augusta University, Augusta, Georgia, 30912, United States|Montefiore Medical Center, Bronx, New York, 10461, United States|Cleveland Clinic Foundation, Cleveland, Ohio, 44195, United States|Prisma Health Upstate, Greenville, South Carolina, 29615, United States|Novartis Investigative Site, Santo Andre, SP, 09090-790, Brazil|Novartis Investigative Site, Sao Paulo, SP, 01323-900, Brazil|Novartis Investigative Site, Beijing, 100730, China|Novartis Investigative Site, Tianjin, 300020, China|Novartis Investigative Site, Tianjin, 300052, China|Novartis Investigative Site, Ostrava, Poruba, 708 52, Czechia|Novartis Investigative Site, Brno Bohunice, 625 00, Czechia|Novartis Investigative Site, Lille, 59037, France|Novartis Investigative Site, Nantes Cedex 1, 44093, France|Novartis Investigative Site, Nice, 06202, France|Novartis Investigative Site, Paris 10, 75475, France|Novartis Investigative Site, Toulouse, 31059, France|Novartis Investigative Site, Aachen, 52074, Germany|Novartis Investigative Site, Dresden, 01307, Germany|Novartis Investigative Site, Essen, 45147, Germany|Novartis Investigative Site, Hamburg, 20246, Germany|Novartis Investigative Site, Riesa, 01589, Germany|Novartis Investigative Site, Ulm, 89081, Germany|Novartis Investigative Site, Ascoli Piceno, AP, 63100, Italy|Novartis Investigative Site, Avellino, AV, 83100, Italy|Novartis Investigative Site, Firenze, FI, 50134, Italy|Novartis Investigative Site, Milano, MI, 20122, Italy|Novartis Investigative Site, Roma, RM, 00161, Italy|Novartis Investigative Site, Torino, TO, 10126, Italy|Novartis Investigative Site, Bassano Del Grappa, Vicenza, 36061, Italy|Novartis Investigative Site, Nagoya, Aichi, 453-8511, Japan|Novartis Investigative Site, Fukushima city, Fukushima, 960 1295, Japan|Novartis Investigative Site, Kanazawa, Ishikawa, 920 8641, Japan|Novartis Investigative Site, Isehara, Kanagawa, 259-1193, Japan|Novartis Investigative Site, Suwa, Nagano, 392-8510, Japan|Novartis Investigative Site, Suita, Osaka, 565 0871, Japan|Novartis Investigative Site, Shinjuku Ku, Tokyo, 160-0023, Japan|Novartis Investigative Site, Kyoto, 606 8507, Japan|Novartis Investigative Site, Niigata, 951 8520, Japan|Novartis Investigative Site, Seoul, 03080, Korea, Republic of|Novartis Investigative Site, Seoul, 06351, Korea, Republic of|Novartis Investigative Site, Vilnius, LT-08661, Lithuania|Novartis Investigative Site, Kota Kinabalu, Sabah, 88586, Malaysia|Novartis Investigative Site, Kuching, Sarawak, 93586, Malaysia|Novartis Investigative Site, Nijmegen, 6500HB, Netherlands|Novartis Investigative Site, Singapore, 119074, Singapore|Novartis Investigative Site, Barcelona, Catalunya, 08036, Spain|Novartis Investigative Site, Santiago De Compostela, Galicia, 15706, Spain|Novartis Investigative Site, San Sebastian, Pais Vasco, 20080, Spain|Novartis Investigative Site, Hualien, 970, Taiwan|Novartis Investigative Site, Taipei, 10002, Taiwan|Novartis Investigative Site, Istanbul, 34093, Turkey|Novartis Investigative Site, Leeds, West Yorkshire, LS9 7TF, United Kingdom|Novartis Investigative Site, London, SE5 9RS, United Kingdom Less << |
NCT04889430 | Atypical Hemolytic Uremic Synd... More >>rome Less << | PHASE3 | RECRUITING | 2029-03-29 | Uni Of Alabama At Birmingham, ... More >>Birmingham, Alabama, 35233, United States|USC Norris Cancer Center, Los Angeles, California, 90033, United States|Univ of California at Los Angeles, Los Angeles, California, 90095, United States|Univ Cali Irvine ALS Neuromuscular, Orange, California, 92868, United States|Harbor-UCLA Medical Center ., Torrance, California, 90502, United States|Georgetown University Lombardi Cancer Center, Washington, District of Columbia, 20007 2197, United States|University Of Miami, Miami, Florida, 33136, United States|Brigham and Womens Hospital, Boston, Massachusetts, 02115, United States|University of Minnesota, Minneapolis, Minnesota, 55455, United States|WA Uni School Of Med, Saint Louis, Missouri, 63110, United States|Rut Univ for Translational Med Scie, New Brunswick, New Jersey, 08901, United States|University of New Mexico, Albuquerque, New Mexico, 87131-0001, United States|Montefiore Medical Center ., Bronx, New York, 10461, United States|Duke University Medical Center, Durham, North Carolina, 27710, United States|University of Cincinnati, Cincinnati, Ohio, 45267-0585, United States|Cleveland Clinic Foundation, Cleveland, Ohio, 44195, United States|Comprehensive Transplant Ctr at OSU, Columbus, Ohio, 43210, United States|UT Southwestern Medical Center, Dallas, Texas, 75390, United States|Baylor Scott and White Research, Temple, Texas, 76502, United States|Virginia Commonwealth University, Richmond, Virginia, 23298, United States|Novartis Investigative Site, Innsbruck, Tyrol, 6020, Austria|Novartis Investigative Site, Wien, 1090, Austria|Novartis Investigative Site, Fortaleza, CE, 60430 370, Brazil|Novartis Investigative Site, Brasilia, DF, 71635-580, Brazil|Novartis Investigative Site, Belo Horizonte, MG, 30150-221, Brazil|Novartis Investigative Site, Pernambuco, Recife, 50740-900, Brazil|Novartis Investigative Site, Porto Alegre, RS, 90035-074, Brazil|Novartis Investigative Site, Botucatu, SP, 18618-970, Brazil|Novartis Investigative Site, Sao Paulo, SP, 01327 001, Brazil|Novartis Investigative Site, Sao Paulo, SP, 04038-002, Brazil|Novartis Investigative Site, Sao Paulo, SP, 05403 000, Brazil|Novartis Investigative Site, Rio de Janeiro, 22270-60, Brazil|Novartis Investigative Site, Salvador, 40301-155, Brazil|Novartis Investigative Site, Guangzhou, Guangdong, 510080, China|Novartis Investigative Site, Nanjing, Jiangsu, 210009, China|Novartis Investigative Site, Yantai, Shandong, 264000, China|Novartis Investigative Site, Beijing, 100034, China|Novartis Investigative Site, Beijing, 100191, China|Novartis Investigative Site, Beijing, 100730, China|Novartis Investigative Site, Shanghai, 200025, China|Novartis Investigative Site, Shanxi, 710063, China|Novartis Investigative Site, Ostrava, Poruba, 708 52, Czechia|Novartis Investigative Site, Prague 4, 146 24, Czechia|Novartis Investigative Site, Praha, 12808, Czechia|Novartis Investigative Site, Thessaloniki, GR, 570 10, Greece|Novartis Investigative Site, Athens, 115 27, Greece|Novartis Investigative Site, Heraklion Crete, 71110, Greece|Novartis Investigative Site, Hyderabad, Andhra Pradesh, 500012, India|Novartis Investigative Site, Thiruvananthapuram, Kerala, 695011, India|Novartis Investigative Site, Nagpur, Maharashtra, 440015, India|Novartis Investigative Site, Pune, Maharashtra, 411011, India|Novartis Investigative Site, Chandigarh, Punjab, 160012, India|Novartis Investigative Site, Chennai, Tamil Nadu, 600006, India|Novartis Investigative Site, Vellore, Tamil Nadu, 632 004, India|Novartis Investigative Site, Lucknow, Uttar Pradesh, 226014, India|Novartis Investigative Site, Iruma-gun, Saitama, 350-0495, Japan|Novartis Investigative Site, Izumo-city, Shimane, 693 8501, Japan|Novartis Investigative Site, Bunkyo ku, Tokyo, 113 8655, Japan|Novartis Investigative Site, Seoul, 03080, Korea, Republic of|Novartis Investigative Site, Seoul, 03722, Korea, Republic of|Novartis Investigative Site, Seoul, 06591, Korea, Republic of|Novartis Investigative Site, Bratislava, 83305, Slovakia|Novartis Investigative Site, Martin, 03601, Slovakia|Novartis Investigative Site, Ljubljana, 1000, Slovenia|Novartis Investigative Site, Taichung, 40447, Taiwan|Novartis Investigative Site, Taoyuan, 33305, Taiwan|Novartis Investigative Site, London, NW1 2BU, United Kingdom|Novartis Investigative Site, Newcastle upon Tyne, NE7 7DN, United Kingdom Less << |
NCT05086744 | Immune Thrombocytopenia (ITP)|... More >>Cold Agglutinin Disease (CAD) Less << | PHASE2 | TERMINATED | 2024-05-17 | Massachusetts General Hospital... More >>, Boston, Massachusetts, 02114, United States|Novartis Investigative Site, Essen, 45147, Germany|Novartis Investigative Site, Milano, MI, 20122, Italy|Novartis Investigative Site, Seoul, 06351, Korea, Republic of|Novartis Investigative Site, Barcelona, Catalunya, 08035, Spain|Novartis Investigative Site, Madrid, 28009, Spain|Novartis Investigative Site, Murcia, 30008, Spain|Novartis Investigative Site, London, W12 0HS, United Kingdom Less << |
NCT03832114 | Glomerulonephritis | PHASE2 | COMPLETED | 2021-04-23 | Novartis Investigative Site, I... More >>owa City, Iowa, 52242, United States|Novartis Investigative Site, Montpellier, 34295, France|Novartis Investigative Site, Paris, 75015, France|Novartis Investigative Site, Essen, 45147, Germany|Novartis Investigative Site, Ranica, BG, 24020, Italy|Novartis Investigative Site, Barcelona, Catalunya, 08035, Spain|Novartis Investigative Site, Madrid, 28041, Spain|Novartis Investigative Site, London, W12 0NN, United Kingdom|Novartis Investigative Site, Newcastle Upon Tyne, NE7 7DN, United Kingdom Less << |
NCT05630001 | Paroxysmal Nocturnal Hemoglobi... More >>nuria Less << | PHASE3 | COMPLETED | 2024-10-17 | City Of Hope National Med Cent... More >>er, Duarte, California, 91010, United States|USC Norris Cancer Center, Los Angeles, California, 90033, United States|Lakes Research, Miami Lakes, Florida, 33014, United States|Mass Gen Hosp Cancer Center, Boston, Massachusetts, 02114, United States|University Of Minnesota, Minneapolis, Minnesota, 55455, United States|Montefiore Medical Center, Bronx, New York, 10461, United States|Cleveland Clinic Foundation, Cleveland, Ohio, 44195, United States|Prisma Health Upstate, Greenville, South Carolina, 29615, United States|Huntsman Cancer Institute Univ of Utah, Salt Lake City, Utah, 84112 0550, United States|Novartis Investigative Site, Nantes Cedex 1, 44093, France|Novartis Investigative Site, Nice, 06202, France|Novartis Investigative Site, Paris 10, 75475, France|Novartis Investigative Site, Aachen, 52074, Germany|Novartis Investigative Site, Dresden, 01307, Germany|Novartis Investigative Site, Essen, 45147, Germany|Novartis Investigative Site, Ulm, 89081, Germany|Novartis Investigative Site, Firenze, FI, 50134, Italy|Novartis Investigative Site, Bassano Del Grappa, Vicenza, 36061, Italy|Novartis Investigative Site, Seoul, 06351, Korea, Republic of|Novartis Investigative Site, Barcelona, Catalunya, 08036, Spain|Novartis Investigative Site, Istanbul, 34093, Turkey|Novartis Investigative Site, Leeds, West Yorkshire, LS9 7TF, United Kingdom|Novartis Investigative Site, London, SE5 9RS, United Kingdom Less << |
NCT05935215 | Atypical Hemolytic Uremic Synd... More >>rome Less << | PHASE3 | RECRUITING | 2029-07-19 | Novartis Investigative Site, N... More >>anjing, Jiangsu, 210009, China|Novartis Investigative Site, Beijing, 100034, China|Novartis Investigative Site, Beijing, 100730, China|Novartis Investigative Site, Shanghai, 200025, China|Novartis Investigative Site, Iruma-gun, Saitama, 350-0495, Japan|Novartis Investigative Site, Bunkyo ku, Tokyo, 113 8655, Japan|Novartis Investigative Site, Ankara, 06500, Turkey|Novartis Investigative Site, Izmir, 35340, Turkey|Novartis Investigative Site, Kocaeli, 41380, Turkey|Novartis Investigative Site, Mersin, 33110, Turkey|Novartis Investigative Site, London, NW1 2BU, United Kingdom|Novartis Investigative Site, Newcastle upon Tyne, NE7 7DN, United Kingdom Less << |
Tags: Iptacopan | LNP023 | LNP 023 | LNP-023 | Complement System | factor B | alternative | pathway | complement | pathogenesis | paroxysmal | nocturnal | hemoglobinuria | PNH | atypical | hemolytic | uremic | syndrome | underlying | cause | complement 3 | glomerulopathy | C3G | inhibitor | 1644670-37-0 |
Precautionary Statements-General | |
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P103 | Read label before use |
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P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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