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Chemical Structure| 1652561-87-9 Chemical Structure| 1652561-87-9

Structure of SAH-SOS1A
CAS No.: 1652561-87-9

Chemical Structure| 1652561-87-9

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SAH-SOS1A is a KRAS-targeting stapled peptide with EC50 values of 106, 109, 154, 140, 155 and 175nM for K-Ras, K-Ras (G12D), K-Ras (G12V), K-Ras (G12C), K-Ras (G12S) and K-Ras (Q61H), respectively. It disrupts the SOS1/KRAS protein interaction and directly inhibit nucleotide association to wild-type and mutant KRAS proteins.

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Product Details of SAH-SOS1A

CAS No. :1652561-87-9
Formula : C100H159N27O28
M.W : 2187.50
SMILES Code : [C@H](CC1=CC=CC=C1)(C(N[C@@H](CC2=CC=CC=C2)C(NCC(N[C@H](C(N[C@]3(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(N)=O)C(O)=O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)[C@@H](C)O)=O)CCCCN)=O)CC(C)C)=O)(C)CCCC=CCCC3)[H])=O)[C@H](CC)C)=O)=O)=O)NC([C@@H](NC([C@H](CCCNC(=N)N)NC(C)=O)=O)CCCNC(=N)N)=O
MDL No. :N/A

Safety of SAH-SOS1A

Related Pathways of SAH-SOS1A

GPCR

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.46mL

0.09mL

0.05mL

2.29mL

0.46mL

0.23mL

4.57mL

0.91mL

0.46mL

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