Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

CAS No. :	166322-31-2
Formula :	C₁₄H₁₉I
M.W :	314.21
SMILES Code :	CC1(C)CCC(C)(C)C2=C1C=C(I)C=C2
English Name :	6-Iodo-1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene
MDL No. :	MFCD31652314

GHS Pictogram:
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Yield	Reaction Conditions	Operation in experiment
88%	With sulfuric acid; iodine; periodic acid In water; acetic acid at 80℃;
85%	With sulfuric acid; iodine; acetic acid; periodic acid In water at 70℃; for 6h;	1.1.1 1.1.1. Synthesis of 6-lodo-1.1.4.4-tetramethyl-1.2.3.4-tetrahydronaphthalene. 1 The synthesis of 6-lodo-l,l,4,4-tetramethyl-l,2,3,4-tetrahydronaphthalene (1) is illustrated in Figure 1(a). l,l,4,4-Tetramethyl-l,2,3,4-tetrahydronaphthalene (11.46 g, 60.9 mmol), (7.77 g, 30.6 mmol) and H5IO6 (3.49 g, 15.3 mmol) were added to a mixture of gl. ethanoic acid/acetic acid (AcOH) (250 mL), H2O (25 mL), and H2SO4 (13 mL), and the resultant solution was stirred at 70 °C for 6 hours. The solution was cooled, and extracted with ethyl ethanoate/ethyl acetate (EtOAc). The organics were washed with sat. Na2S2C>3, H2O and brine, dried (MgSC ) and evaporated to give a crude orange oil (17 g). This was purified by dry column vacuum chromatography (eluting with heptane) to give compound 1 as a white solid (16.3 g, 85%): 1H NMR (700 MHz, CDCI3) d 1.25 (s, 6H), 1.26 (s, 6H), 1.66 (s, 4H), 7.04 (d, J = 8.4 Hz, 1H), 7.43 (dd, J = 8.4, 1.9 Hz, 1H), 7.60 (d, J = 1.9 Hz, 1H); 13C NMR (176 MHz, CDCI3) d 31.9, 32.0, 34.4, 34.6, 35.0, 35.1, 91.3, 128.9, 134.8, 135.8, 144.8, 147.9; all other data matched the literature (V. B. Christie et al, Org. Biomol. Chem., 2008, 6, 3497-3507).
71%	With sulfuric acid; iodine; periodic acid In water; acetic acid at 70℃; for 4h;

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CAS No.: 166322-31-2

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CAS No.: 166322-31-2

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[ 166322-31-2 ] Synthesis Path-Downstream 1~5

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	With sulfuric acid; iodine; acetic acid; periodic acid In water at 70℃;	1 Alkyne 7 was prepared as a generic synthon, starting with iodination of 1 ,1 ,4,4-tetramethyl- 1,2,3,4-tetrahydronaphthalene to give 5, followed by cross-coupling to TMSA under Sonogashira conditions and finally deprotection (Scheme 2) according to optimised procedures.(lO)
	With sulfuric acid; iodine In water; acetic acid at 70℃;

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed