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[ CAS No. 16782-41-5 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 16782-41-5
Chemical Structure| 16782-41-5
Structure of 16782-41-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 16782-41-5 ]

CAS No. :16782-41-5 MDL No. :MFCD11185568
Formula : C12H19NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 209.28 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 16782-41-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 16782-41-5 ]

[ 16782-41-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 665-66-7 ]
  • [ 79-11-8 ]
  • [ 16782-41-5 ]
YieldReaction ConditionsOperation in experiment
73% With sodium hydroxide; In ethanol; water; at 93℃; for 24h;pH 11.5; Amantadine HC1 (1.88 g, 10 mmol) and chloroacetic acid (1.91 g, 20 mmol) were added to a 50:50 ethanolic aqueous mixture (80 mL) in a 2: 1 molar ratio that was then titrated to pH = 1 1.5 using NaOH. The mixture was refluxed at 93 C for 24 h while maintaining an alkaline pH (11-12). Ethanol was removed from the mixture via rotary evaporation allowing the water insoluble product to precipitate out of solution. Following filtration, the white precipitate was washed with diethyl ether three times (10 mL each) and dried at room temperature. Yield: 1.532 g (73%). 1HNMR (500 MHz, D20, 25 C): delta = 3.40 (s, 2H), 2.02 (s, 3H), 1.72 (s, 6H), 1.48-1.59 (dd, 6H) ppm. 13 CNMR- 1 HNMR (500 MHz, D20, 25 C): delta = 172.8, 58.2, 38.9, 36.5, 30.1 ppm. HRMS (ESI): m/z calc for Ci2H19N02 + H+: 210.15; found 210.14. Decompo C.
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