Structure of Infliximab
CAS No.: 170277-31-3
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Infliximab is a chimeric IgG1 monoclonal antibody that inhibits TNFα by preventing its binding to receptors. Infliximab has potential for research in rheumatoid arthritis, Crohn's disease, and ulcerative colitis.
Synonyms: Avakine; CT-P13
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Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 170277-31-3 |
M.W : | 145.88 kDa |
SMILES Code : | NONE |
Synonyms : |
Avakine; CT-P13
|
MDL No. : | N/A |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319 |
Precautionary Statements: | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
In Vitro:
Concentration | Treated Time | Description | References |
CCD18Co cells | 10 ng/ml | 2 h | To assess the impact of OSM on inflammatory responses in intestinal stromal cells, results showed that OSM significantly induced the expression of IL6 and various chemokines | PMC5420447 |
LPMNC from IBD patients | 10 µg/mL | 18 h | To test the effect of Infliximab on the release of inflammatory cytokines in LPMNC from IBD patients, results showed that Infliximab significantly reduced the release of IL-1β, IL-6, TNFα, CCL2, Mip-1α, and IP-10. | PMC6145287 |
NCM460 | 5 ng/mL | 0–60 min | To measure the dose-dependent effect of SPINK4 on EGFR phosphorylation | PMC11245600 |
HT-29 | 5 ng/mL | 0–60 min | To measure the dose-dependent effect of SPINK4 on EGFR phosphorylation | PMC11245600 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Mice | C57BL/6J mice | Subcutaneous injection | 30.75 µg/g | Single injection, lasted for 2 weeks | To evaluate the causative effect of antibiotic treatment on ADA formation, results showed that mice pretreated with cephalosporins had significantly higher ADA levels compared to those pretreated with macrolides, and germ-free mice produced no detectable ADA. | PMC8762017 |
mice | TNBS-induced colitis model | intravenous injection | 5 mg/kg | once daily for 5 days | To monitor the effect of anti-tumor necrosis factor α antibody therapy using P-selectin-targeted US imaging, results showed a significant decrease in US signal in treated mice, which correlated well with P-selectin expression levels. | PMC3244669 |
Mice | DSS-induced colitis model | Intraperitoneal injection | 10 mg/kg | Single injection, lasting 7 days | Infliximab suppressed DSS-induced PUMA expression and colitis, alleviating colonic damage and IEC apoptosis. | PMC3083802 |
Mice | TNFdARE mouse model | Intraperitoneal injection | 100 µg/mouse | Twice a week for 15 days | To evaluate the efficacy of Infliximab in TNFdARE mice, the results showed that Infliximab significantly suppressed inflammatory gene expression, but histological improvement was not significant. | PMC9282884 |
Mice | DSS-induced colitis model | Intraperitoneal injection | 5 mg/kg | 2 consecutive days | To evaluate the therapeutic effect of Infliximab on colitis | PMC11245600 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00325078 | Chronic Granulomatous Disease|... More >>Crohn'S-like IBD|Inflammatory Bowel Disease (IBD) Less << | PHASE1|PHASE2 | TERMINATED | 2025-06-12 | National Institutes of Health ... More >>Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States Less << |
NCT02566889 | Inflammatory Bowel Diseases | PHASE4 | TERMINATED | 2025-07-19 | Phoenix, Arizona, United State... More >>s|Los Angeles, California, United States|San Francisco, California, United States|Hartford, Connecticut, United States|Wilmington, Delaware, United States|Atlanta, Georgia, United States|Chicago, Illinois, United States|Peoria, Illinois, United States|Indianapolis, Indiana, United States|Shreveport, Louisiana, United States|Portland, Maine, United States|Baltimore, Maryland, United States|Boston, Massachusetts, United States|Waltham, Massachusetts, United States|Rochester, Minnesota, United States|Saint Paul, Minnesota, United States|Kansas City, Missouri, United States|Mineola, New York, United States|New York, New York, United States|Stony Brook, New York, United States|Chapel Hill, North Carolina, United States|Cleveland, Ohio, United States|Philadelphia, Pennsylvania, United States|Pittsburgh, Pennsylvania, United States|Charleston, South Carolina, United States|Dallas, Texas, United States|Fort Worth, Texas, United States|Fairfax, Virginia, United States|Madison, Wisconsin, United States|Vancouver, British Columbia, Canada|Halifax, Nova Scotia, Canada|Hamilton, Ontario, Canada|London, Ontario, Canada|Toronto, Ontario, Canada|Montreal, Quebec, Canada|Sherbrooke, Quebec, Canada Less << |
NCT03192878 | Takayasu Arteritis | UNKNOWN | 2025-07-19 | IRCCS Ospedale San Raffaele, M... More >>ilano, MI, 20132, Italy Less << | |
NCT00106847 | Psoriasis|Parapsoriasis | PHASE3 | COMPLETED | 2025-07-05 | - |
NCT03765450 | Ulcerative Colitis | ACTIVE_NOT_RECRUITING | 2025-12-24 | UCSD, San Diego, California, 9... More >>2037, United States|Cornell University, New York, New York, 10065, United States|London Health Sciences Center, London, Ontario, N6A 5A5, Canada|Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada Less << | |
NCT01256489 | Stevens-Johnson Syndrome|Corne... More >>al Blindness Less << | PHASE1|PHASE2 | WITHDRAWN | 2025-01-15 | Massachusetts Eye and Ear Infi... More >>rmary, Boston, Massachusetts, 02114, United States Less << |
NCT02088944 | Serological C Reactive Protein... More >> or Erythrocyte Sedimentation Rate Less << | UNKNOWN | - | - | |
NCT03937609 | Colitis, Ulcerative | PHASE4 | TERMINATED | 2024-12-15 | St Vincent's University Hospit... More >>al, Dublin, Ireland|Academic Medical Center, Amsterdam, Netherlands|OLVG Oost, Amsterdam, Netherlands|Radboud UMC, Nijmegen, Netherlands|Klinikk Baerum Sykehus, B?rums Verk, Norway|Akerhus University Hospital, L?renskog, Norway|Helse Stavanger, Stavanger, Norway Less << |
NCT01220518 | Ankylosing Spondylitis | PHASE1 | COMPLETED | 2025-06-12 | Inha University Hostpital, Inc... More >>heon, Korea, Republic of Less << |
NCT01349920 | Crohn Disease | COMPLETED | 2015-09-28 | - | |
NCT01971814 | Ulcerative Colitis (UC)|Inflam... More >>matory Bowel Disease Less << | PHASE1 | COMPLETED | 2025-01-15 | University of California at Sa... More >>n Francisco, San Francisco, California, 94143, United States Less << |
NCT06614387 | Ulcerative Colitis | PHASE3 | NOT_YET_RECRUITING | 2028-11-30 | - |
NCT02522169 | Pediatric Crohns Disease | UNKNOWN | 2025-12-16 | - | |
NCT00006292 | Rheumatoid Arthritis | PHASE2 | COMPLETED | 2025-09-05 | National Institute of Arthriti... More >>s and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, Maryland, 20892, United States Less << |
NCT00201799 | Graft-Versus-Host Disease | PHASE2 | COMPLETED | 2025-03-08 | Ohio State University, Columbu... More >>s, Ohio, 43210, United States Less << |
NCT05719389 | Inflammatory Bowel Diseases|Rh... More >>eumatologic Disease Less << | RECRUITING | 2025-04-20 | Irccs Ospedale San Raffaele, M... More >>ilano, 20132, Italy Less << | |
NCT00106834 | Psoriasis | PHASE3 | COMPLETED | 2025-10-04 | - |
NCT02770794 | Arthritis, Rheumatoid | PHASE4 | COMPLETED | 2020-08-14 | Chiba University Hospital, Chi... More >>ba, 260-8677, Japan Less << |
NCT04312659 | Crohn Disease | COMPLETED | 2023-09-12 | Guangzhou Women And Children's... More >> Medical Center, Guangzhou, 510623, China|The Children's Hospital, Zhejiang University School Of Medicine, Hangzhou, 310052, China|Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, 200025, China|Children's Hospital of Fudan University, Shanghai, 201102, China|Henan Children's Hospital, Zhengzhou Children's Hospital, ZhengZhou, 450018, China Less << | |
NCT03452501 | Inflammatory Bowel Diseases|Cr... More >>ohn Disease|Fistulizing Crohn's Disease|Ulcerative Colitis Less << | COMPLETED | 2020-08-17 | King Abdulaziz University Hosp... More >>ital, Jeddah, Saudi Arabia|Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia|King Abdullah International Medical Research Center, Riyadh, 11426, Saudi Arabia|King Saud Medical City, Riyadh, Saudi Arabia Less << | |
NCT02505568 | Behcet Disease | PHASE3 | COMPLETED | 2018-07-13 | Busan, Korea, Republic of|Daeg... More >>u, Korea, Republic of|Gangwon-do, Korea, Republic of|Gyeonggi-do, Korea, Republic of|Seoul, Korea, Republic of Less << |
NCT00236028 | Rheumatoid Arthritis | PHASE3 | COMPLETED | 2025-04-03 | - |
NCT00036439 | Ulcerative Colitis | PHASE3 | COMPLETED | 2025-01-07 | - |
NCT04779892 | Rheumatoid Arthritis | PHASE1 | COMPLETED | 2020-06-15 | Shanghai Xuhui Central Hospita... More >>l, Shanghai, Shanghai, 200031, China Less << |
NCT00823641 | HTLV-I-associated Myelopathy | PHASE2 | TERMINATED | 2025-03-11 | Imperial College Healthcare NH... More >>S Trust, London, W2 1PG, United Kingdom Less << |
NCT00462072 | Rheumatoid Arthritis|Psoriatic... More >> Arthritis|Psoriasis|Crohn's Disease Less << | PHASE4 | COMPLETED | 2025-08-10 | University of Rochester, Roche... More >>ster, New York, 14642, United States Less << |
NCT00741104 | Rheumatoid Arthritis | COMPLETED | 2025-06-08 | - | |
NCT00443222 | Refractory Myositis | PHASE2|PHASE3 | COMPLETED | - | - |
NCT05280405 | Inflammatory Bowel Diseases | PHASE4 | RECRUITING | 2025-01-31 | Institute for Maternal and Chi... More >>ld Health - IRCCS "Burlo Garofolo", Trieste, 34137, Italy Less << |
NCT00036374 | Rheumatoid Arthritis, Juvenile | PHASE3 | COMPLETED | 2025-12-06 | - |
NCT03445624 | Inflammatory Bowel Diseases | COMPLETED | 2021-10-01 | Hyam Fathy, Assiut, Egypt | |
NCT00033891 | Dermatomyositis|Polymyositis | PHASE2 | COMPLETED | 2010-05-20 | National Institutes of Health ... More >>Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States Less << |
NCT00076726 | Giant Cell Arteritis | PHASE2 | TERMINATED | 2025-07-05 | - |
NCT01850121 | Ankylosing Spondylitis | COMPLETED | 2025-05-08 | Sahlgrenska University Hospita... More >>l, Gothenburg, S-413 45, Sweden Less << | |
NCT02799615 | Colitis, Ulcerative|Bowel Dise... More >>ases, Inflammatory Less << | COMPLETED | 2025-11-19 | Connecticut Children's Hospita... More >>l Medical Center, Hartford, Connecticut, 06016, United States|Emory University School of Medicine, Atlanta, Georgia, 30322, United States|Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, United States|Nationwide Children's Hospital, Columbus, Ohio, 43205, United States|Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, United States|Rhode Island Hospital, Providence, Rhode Island, 02903, United States|The Hospital for Sick Children, Toronto, Ontario, Canada Less << | |
NCT00791557 | Pyoderma Gangrenosum|Crohn's D... More >>isease|Ulcerative Colitis|Inflammatory Bowel Disease Less << | COMPLETED | 2025-02-10 | University Hospitals Cleveland... More >> Medical Center, Cleveland, Ohio, 44106, United States Less << | |
NCT04272788 | Crohn Disease | COMPLETED | 2019-09-29 | SAHWenzhouMU, Wenzhou, Zhejian... More >>g, China Less << | |
NCT00523354 | Esophagitis | PHASE2 | COMPLETED | 2025-10-07 | EE-Clinics, Praxis Roemerhof, ... More >>Olten, SO, 4600, Switzerland Less << |
NCT01661257 | Crohn's Disease | PHASE3 | COMPLETED | 2025-06-11 | Samsung Medical Center, Seoul,... More >> 135-710, Korea, Republic of Less << |
NCT05340764 | Inflammatory Bowel Diseases | PHASE4 | COMPLETED | 2023-05-04 | Washington University School o... More >>f Medicine, Saint Louis, Missouri, 63110, United States Less << |
NCT04655729 | Crohn Disease | UNKNOWN | 2023-01-01 | MassGeneral for Children, Bost... More >>on, Massachusetts, 02114, United States Less << | |
NCT02638701 | Aneurysm|Stroke|Vasculitis|Tum... More >>or Necrosis Factor-alpha Less << | PHASE1|PHASE2 | ENROLLING_BY_INVITATION | 2025-12-26 | UCSF Medical Center, San Franc... More >>isco, California, 94143, United States Less << |
NCT00571337 | Crohn Disease | PHASE3 | COMPLETED | 2025-07-10 | Gent University Hospital, Gent... More >>, 9000, Belgium|CHU LIEGE - Sart Tilman, Liege, 4000, Belgium|Chu Amiens, Amiens, 80054, France|Chu Besancon, Besancon, 25030, France|Hopital Saint Andre, Bordeaux, 33075, France|CHU CAEN, Caen, 14033, France|Hopital Beaujon, Clichy, 92110, France|Hopital Louis Mourier, Colombes, 92700, France|Hopital Henri Mondor, Creteil, 94010, France|CHRU Lille, Lille, France|Chu Marseille - Hopital Nord, Marseille, 13915, France|Ch Le Raincy Montfermeil, Montfermeil, 93370, France|Chu Montpellier, Montpellier, 34295, France|Chu Nantes, Nantes, 44093, France|Hopital Lariboisiere, Paris, 75010, France|Hopital Saint Louis, Paris, 75010, France|Hopital Georges Pompidou, Paris, 75015, France|Hopital Haut Leveque, Pessac, 33604, France|CHU LYON, Pierre Benite, 69495, France|Chu Rouen, Rouen, 76031, France|Chu Strasbourg, Strasbourg, 67091, France|Chu Toulouse, Toulouse, 31403, France|Chu Tours, Tours, 37044, France Less << |
NCT05906576 | Crohn Disease | PHASE4 | RECRUITING | 2025-02-27 | Beijing Children's Hospital, C... More >>apital Medical University, Beijing, China Less << |
NCT02060318 | Crohn Disease | COMPLETED | 2016-03-07 | Hvidovre Hospital, Hvidovre, C... More >>openhagen, 2650, Denmark Less << | |
NCT01266785 | Crohn's Disease | WITHDRAWN | 2025-07-12 | Oregon Health & Science Univer... More >>sity, Portland, Oregon, 97239, United States Less << | |
NCT01217086 | Rheumatoid Arthritis | PHASE3 | COMPLETED | 2025-07-12 | Hanyang University Medical Cen... More >>ter, Seoul, Korea, Republic of Less << |
NCT00075075 | Scleritis | PHASE1 | COMPLETED | 2007-09-06 | National Institutes of Health ... More >>Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States Less << |
NCT00029042 | Juvenile Rheumatoid Arthritis | PHASE2 | TERMINATED | 2025-10-05 | National Institute of Arthriti... More >>s and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, Maryland, 20892, United States Less << |
NCT02770040 | Ulcerative Colitis | PHASE4 | COMPLETED | 2022-09-07 | Austin Health, Melbourne, Vict... More >>oria, 3084, Australia Less << |
NCT04425538 | COVID-19 | PHASE2 | COMPLETED | 2021-01-22 | Tufts Medical Center, Boston, ... More >>Massachusetts, 02111, United States Less << |
NCT01148901 | Ankylosing Spondylitis | PHASE4 | WITHDRAWN | 2025-12-10 | - |
NCT02605642 | Rheumatoid Diseases|Rheumatoid... More >> Arthritis|Ankylosing Spondylitis|Psoriatic Arthritis Less << | COMPLETED | 2018-12-31 | MHAT Trimontium OOD, Plovdiv, ... More >>4000, Bulgaria|MHAT Kaspela EOOD, Plovdiv, 4001, Bulgaria|Diagnostic Consultative Center 17 Sofia EOOD, Sofia, 1233, Bulgaria|Lucere Skin Dermatology & Laser Clinic, Edmonton, Alberta, T6X 0N9, Canada|Nexus Clinical Research, St. John's, Newfoundland and Labrador, A1A 5E8, Canada|Dr. Juris Lazovskis Inc., Sydney, Nova Scotia, B1S 3N1, Canada|The Waterside Clinic, Barrie, Ontario, L4M 6L2, Canada|William Osler Health System, Brampton, Ontario, L6T 3J1, Canada|Adachi Medicine Professional Corporation, Hamilton, Ontario, L8N 1Y2, Canada|K-W Musculoskeletal Research Inc, Kitchener, Ontario, N2M 5N6, Canada|Y. Liu Medicine Professional, Milton, Ontario, L9T 3Z9, Canada|Credit Valley Imaging Associates, Mississauga, Ontario, L5M 2V8, Canada|Oakville Rheumatology & Osteoporosis, Oakville, Ontario, L6M 4J2, Canada|Ottawa Hospital Research Institute, Ottawa, Ontario, K1Y 4G2, Canada|Arthur Karasik Medicine Professional Corporation, Toronto, Ontario, M9C 5N2, Canada|Dr. Sabeen Anwar Medicine Professional Corporation, Windsor, Ontario, N8X 1T3, Canada|Centre Hospitalier de l'Universite de Montreal - Notre-Dame Hospital, Montreal, Quebec, H2L 1S6, Canada|Centre Rhumatologie de l'Est, Rimouski, Quebec, G5L 8W1, Canada|Centre de Recherche Musculo-Squelettique, Trois-Rivières, Quebec, G8Z 1Y2, Canada|Groupe de Recherche en Rhumatologie et Maladies Osseuses (GRMO), Quebec, G1V 3M7, Canada|Revmatolog Mudr. Sirova Klara s.r.o., Ostrava, 701 00, Czechia|Revmatologicky ústav (Rú), Praha 2, 12850, Czechia|Rheumapraxis Steglitz, Berlin, 12163, Germany|Immanuel Diakonie GmbH, Bernau, 16321, Germany|Rheumatologisches MVZ Dresden GmbH, Dresden, 01109, Germany|Asklepios Gesundheitszentrum Elmshorn, Elmshorn, 21073, Germany|Rheumatologische Praxis Dr. med. Kühne, Haldensleben, 39340, Germany|Dr. med. J?rg Kaufmann, Ludwigsfelde, 14974, Germany|Praxis Dr. Herbert Kellner, Muenchen, 80639, Germany|MVZ für Rheumatologie Dr. Martin Welcker GmbH, Planegg, 82152, Germany|Berufsausübungsgemeinschaft Martin Bohl-Bühler & Dr. med. Sabine Reckert, Potsdam, 14469, Germany|Dr. med. Jochen Walter - FA für Innere Medizin Rheumatologe, Rendsburg, 24768, Germany|University General Hospital of Heraklion, Heraklion, Crete, 71110, Greece|Complexo Hospitalario Universitario A Coru?a, A Coru?a A Coru?a, 15006, Spain|Hospital Universitario Vall d'Hebron, Barcelona, 08035, Spain|Hospital Universitario de Canarias, San Cristóbal de La Laguna, 38320, Spain|Portsmouth Hospitals NHS Trust - Queen Alexandra Hospital, Portsmouth, PO6 3LY, United Kingdom|Salisbury NHS Foundation Trust - Salisbury District Hospital, Sailsbury, SP2 8BJ, United Kingdom Less << | |
NCT00051623 | Arthritis, Psoriatic | PHASE3 | COMPLETED | 2025-06-04 | - |
NCT00056264 | Chronic Obstructive Pulmonary ... More >>Disease|COPD Less << | PHASE3 | COMPLETED | 2025-12-04 | - |
NCT00724243 | Rheumatoid Arthritis | COMPLETED | 2025-10-08 | - | |
NCT05552287 | Crohn Disease|Child, Only|Biol... More >>ogic; Inadequate Less << | PHASE4 | RECRUITING | 2025-08-25 | Erasmus Medical Center, Rotter... More >>dam, 3015 GD, Netherlands Less << |
NCT06274294 | Inflammatory Bowel Diseases | PHASE3 | RECRUITING | 2025-01-25 | Institut des MICI, Neuilly-sur... More >>-Seine, 92200, France Less << |
NCT03209232 | Ulcerative Colitis | TERMINATED | 2021-09-01 | Schenider Children's Medical C... More >>enter, Peta? Tiqwa, 4920235, Israel Less << | |
NCT00096655 | Ulcerative Colitis | PHASE3 | COMPLETED | 2025-08-07 | - |
NCT00073437 | Sarcoidosis | PHASE3 | COMPLETED | 2025-02-05 | - |
NCT00228839 | Graft vs Host Disease | PHASE1 | COMPLETED | 2025-10-06 | Children's Healthcare of Atlan... More >>ta/Emory University, Atlanta, Georgia, 30322, United States Less << |
NCT04835506 | Crohn Disease|Ulcerative Colit... More >>is|Inflammatory Bowel Diseases Less << | PHASE4 | ENROLLING_BY_INVITATION | 2024-12-31 | Yale University School of Medi... More >>cine, New Haven, Connecticut, 06510, United States|University of Miami, Miami, Florida, 33136, United States|University of Chicago Medicine, Chicago, Illinois, 60637, United States|Northwestern University, Evanston, Illinois, 60208, United States|Rockford GI, Rockford, Illinois, 61107, United States|University of Maryland Medical Center, Baltimore, Maryland, 21201, United States|Boston Children's Hospital, Boston, Massachusetts, 02115, United States|Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States|Lahey Hospital and Medical Center, Burlington, Massachusetts, 01805, United States|University of Minnesota, Minneapolis, Minnesota, 55455, United States|Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, 03766, United States|NYU Langone Health, New York, New York, 10016, United States|Icahn School of Medicine at Mount Sinai, New York, New York, 10029, United States|Weill Cornell Medical College, New York, New York, 10065, United States|Atrium Health Center for Digestive Health, Charlotte, North Carolina, 28204, United States|Cleveland Clinic, Cleveland, Ohio, 44195, United States|Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, United States|LifeSpan Brown University, Providence, Rhode Island, 02915, United States|Medical University of South Carolina, Charleston, South Carolina, 29425, United States|Vanderbilt University Medical Center, Nashville, Tennessee, 20500, United States|University of Texas Southwestern Medical Center, Dallas, Texas, 75390, United States|University of Utah, Salt Lake City, Utah, 84132, United States|Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, United States|London Health Sciences Centre - Children's Hospital, London, Canada|McGill University Health Centre (MUHC) Montreal General Hospital, Montreal, Canada Less << |
NCT00036387 | Arthritis, Rheumatoid | PHASE3 | COMPLETED | 2025-11-03 | - |
NCT01408810 | Ulcerative Colitis | PHASE4 | COMPLETED | 2025-11-12 | Hospital de S?o Jo?o, Porto, 4... More >>200-319, Portugal Less << |