Structure of Avapritinib
CAS No.: 1703793-34-3
*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
BLU-285 is a potent KIT receptor and PDGFRα dual inhibitor with IC50 of 0.27 and 0.24 nM for KIT (D816V) and PDGFRα (D842V) respectively, developed as a highly targeted therapy for SM.
Synonyms: BLU-285
4.5
*For Research Use Only !
Change View
Size | Price | VIP Price | US Stock |
Global Stock |
In Stock | ||
{[ item.pr_size ]} |
Inquiry
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.discount_usd) ]} {[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} |
Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]} | Inquiry {[ item.pr_usastock ]} In Stock Inquiry - | {[ item.pr_chinastock ]} {[ item.pr_remark ]} In Stock 1-2 weeks - Inquiry - | Login | - + | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
1-2weeks
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price, item.pr_usd) ]}
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
In Stock
- +
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 1703793-34-3 |
Formula : | C26H27FN10 |
M.W : | 498.56 |
SMILES Code : | N[C@@](C)(C1=CC=C(F)C=C1)C2=CN=C(N3CCN(C4=NC=NN5C4=CC(C6=CN(C)N=C6)=C5)CC3)N=C2 |
Synonyms : |
BLU-285
|
MDL No. : | MFCD31544325 |
InChI Key : | DWYRIWUZIJHQKQ-SANMLTNESA-N |
Pubchem ID : | 118023034 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Target |
|
In Vitro:
Cell Line
|
Concentration | Treated Time | Description | References |
PDGFRA D842V PDX cells | 100 nM | 24 h | Evaluate the effect of ML-7 and Avapritinib on the cytoskeleton | PMC10239357 |
GIST882 | 120 nM | 120 h | Evaluate the effects of MK-1775 and avapritinib on three-dimensional spheroid growth. Results showed that combination treatment significantly reduced spheroid viability and volume. | PMC7934848 |
GIST-T1+D842V KITKO | 103.8 nM | 72 h | Evaluate the effects of MK-1775 and avapritinib on cell cycle and apoptosis. Results showed that MK-1775 induced G0/G1-phase arrest, while avapritinib induced G2 arrest. Combination treatment significantly increased the subG1 population, indicating increased apoptosis. | PMC7934848 |
GIST-T1+Cas9 | 19.6 Nm | 72 h | Evaluate the effects of MK-1775 and avapritinib on cell cycle and apoptosis. Results showed that MK-1775 induced G2 phase cell cycle arrest, while avapritinib induced G0/G1-phase arrest. Combination treatment significantly increased the subG1 population, indicating increased apoptosis. | PMC7934848 |
GIST T1 cells | 100 nM | 24 or 48 h | Evaluate the effect of Avapritinib on GIST T1 cell viability and MYLK upregulation | PMC10239357 |
S1-M1-80 | 0.1 – 1.0 μM | 72 h | avapritinib reversed ABCG2-mediated mitoxantrone resistance | PMC6620786 |
KB-3-1 | 0.1 – 1.0 μM | 72 h | avapritinib resensitized ABCB1-overexpressing KB-V1 cancer cells to paclitaxel at non-toxic concentrations | PMC6620786 |
HEK293 | 20 μM | To evaluate the effect of avapritinib on the drug transport function of ABCB1 and ABCG2 | PMC6620786 |
In Vivo:
Species
|
Animal Model
|
Administration | Dosage | Frequency | Description | References |
C.B17 SCID mice | GIST-T1+Cas9 and GIST-T1+D842V KITKO xenograft models | Oral | 10 mg/kg | Daily administration until tumor volume exceeded 10% of body weight or animals demonstrated distress or weight loss greater than 10%. | Evaluate the effects of MK-1775 and avapritinib combination therapy on tumor growth and survival. Results showed that combination treatment significantly inhibited tumor growth and induced tumor regression in the GIST-T1+D842V KITKO model. Combination treatment significantly prolonged survival. | PMC7934848 |
NSG mice | PDGFRA D842V-mutant GIST xenograft model | Oral gavage | 3, 10 or 30 mg/kg | Once daily for 2 weeks | Evaluate the effect of Avapritinib alone or in combination with ML-7 on tumor volume and signaling pathways | PMC10239357 |
Mice | H3.3K27M/p53LOF/PDGFRAWT (KPP) model | Oral administration | 30 mg/kg | 15 consecutive days | Evaluation of the therapeutic effect of avapritinib on the KPP model showed that avapritinib significantly extended survival (median survival 18 days vs. 26 days, P=0.0023). | PMC10326601 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03465722 | GIST | Phase 3 | Recruiting | April 2023 | - |
NCT03731260 | Indolent Systemic Mastocytosis... More >> Smoldering Systemic Mastocytosis Less << | Phase 2 | Not yet recruiting | November 2023 | - |
NCT02508532 | Gastrointestinal Stromal Tumor... More >>s (GIST)|Other Relapsed or Refractory Solid Tumors Less << | PHASE1 | COMPLETED | 2021-06-03 | Scottsdale Healthcare Hospital... More >>s DBA HonorHealth, Scottsdale, Arizona, 85258, United States|Sarcoma Oncology Center, Santa Monica, California, 90403, United States|Sylvester Comprehensive Cancer Center, Miami, Florida, 33136, United States|Cancer Treatment Centers of America, Atlanta, Georgia, 30256, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02215, United States|Memorial Sloan Kettering Cancer Center, New York, New York, 10065, United States|Oregon Health and Science University, Portland, Oregon, 97239, United States|Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States|MD Anderson Cancer Center, Houston, Texas, 77030, United States|Leuven Cancer Institute University Hospitals Leuven, Leuven, 3000, Belgium|Centre Leon Berard, Lyon, 69008, France|Institut Gustave Roussy, Paris, 94805, France|University of Duisburg-Essen, Essen, 45122, Germany|Fondazione IRCCS - Istituto Nazinale dei Tumori, Milan, 20133, Italy|Asan Medical Center, Seoul, 05505, Korea, Republic of|Erasmus MC Cancer Institute, Rotterdam, 3015, Netherlands|Centrum Onkologii-Instytut im. Marii Sk?odowskiej-Curie w Warszawie, Warsaw, 02-781, Poland|Vall d' Hebron Institute of Oncology (VHIO), Barcelona, 08305, Spain|Royal Marsden Hospital, London, SW3 6JJ, United Kingdom Less << |
NCT02561988 | Aggressive Systemic Mastocytos... More >>is|Systemic Mastocytosis-associated Hematologic Non-mast Cell Disease|Mast Cell Leukemia|Relapsed or Refractory Myeloid Malignancies Less << | PHASE1 | COMPLETED | 2023-01-19 | Stanford Cancer Institute, Sta... More >>nford, California, 94305, United States|University of Colorado Cancer Center, Denver, Colorado, 80045, United States|Emory University, Atlanta, Georgia, 30322, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02215, United States|University of Michigan Health System, Ann Arbor, Michigan, 48109, United States|Mount Sinai Hospital, New York, New York, 10029, United States|University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States|MD Anderson Cancer Center, Houston, Texas, 77030, United States|Huntsman Cancer Institute, Salt Lake City, Utah, 84112, United States|Beatson West of Scotland Cancer Centre, Glasgow, G12 0XL, United Kingdom|Guy's Hospital, London, SE1 9RT, United Kingdom Less << |
NCT03580655 | Advanced Systemic Mastocytosis... More >>|Aggressive Systemic Mastocytosis|Systemic Mastocytosis With an Associated Hematologic Neoplasm|Mast Cell Leukemia Less << | PHASE2 | ACTIVE_NOT_RECRUITING | 2026-01-31 | Stanford Cancer Institute, Sta... More >>nford, California, 94305, United States|Rush University Medical Center, Chicago, Illinois, 60612, United States|The University of Kansas Cancer Center, Westwood, Kansas, 66205, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02215, United States|University of Michigan, Ann Arbor, Michigan, 48109, United States|Washington University School of Medicine, Saint Louis, Missouri, 63110, United States|Roswell Park Comprehensive Cancer Center, Buffalo, New York, 14263, United States|Herbert Irving Comprehensive Cancer Center, New York, New York, 10032, United States|University of Pennsylvania, Abramson Cancer Center, Philadelphia, Pennsylvania, 19104, United States|University of Texas, MD Anderson Cancer Center, Houston, Texas, 77030, United States|Mays Cancer Center, San Antonio, Texas, 78229, United States|Huntsman Cancer Institute, Salt Lake City, Utah, 84112, United States|Medizinische Universit?t Wien, Universit?tsklinik für Innere Medizin I, Klinische Abteilung für H?matologie und H?mostaseologie, Vienna, 1090, Austria|St. Michael's Hospital, Toronto, Ontario, M5B 1W8, Canada|Odense University Hospital, Department of Haematology, Odense, DK-5000, Denmark|H?pital Necker-Enfants Malades, Paris, 75015, France|CHU Toulouse - H?pital Larrey, Toulouse, 31059, France|Uniklinik RWTH Aachen, Klinik für H?matologie, Onkologie, H?mostaseologie und Stammzelltranslplantation, Aachen, 52074, Germany|Universit?tsklinikum Hamburg-Eppendorf, Zentrum für Onkologie, Hamburg, 20246, Germany|Universit?tsklinikum Leipzig, Medizinische Klinik und Poliklinik I - H?matologie und Zelltherapie, lnternistische Onkologie, H?mostaseologie, Leipzig, 04103, Germany|Universit?tsmedizin Mannheim III. Medizinische Klinik, Mannheim, 68167, Germany|Klinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar der TU München, Munich, 81675, Germany|Azienda Ospedaliero-Universitaria Careggi, CRIMM - Centro di Ricerca ed Innovazione per le Malattie Mieloproliferative, Florence, 50134, Italy|A.O. OO.RR. S.Giovanni di Dio e Ruggi d'Aragona, University of Salerno, Salerno, 84131, Italy|Centro Ricerche Cliniche di Verona - Azienda Ospedaliera Universitaria Integrata di Verona, Verona, 37134, Italy|University Medical Center Groningen (UMCG), Groningen, 9713 GZ, Netherlands|Oslo University Hospital-Rikshospitalet, Hematology, Oslo, 0372, Norway|Uniwersyteckie Centrum Kliniczne, Klinika Hematologii i Transplantologii, Gdańsk, 80-214, Poland|Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroc?awiu, Klinice Hematologii, Nowotworów Krwi i Transplantacji Szpiku, Wroc?aw, 50-367, Poland|lnstituto de Estudios de Mastocitosis de Castilla la Mancha, Hospital Virgen del Valle - Complejo Hospitalario de Toledo, Toledo, 45071, Spain|Beatson West of Scotland Cancer Centre - NHS Greater Glasgow and Clyde, Glasgow, G12 0YN, United Kingdom|Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital, London, SE1 9RT, United Kingdom Less << |
NCT04771520 | Anatomic Stage IV Breast Cance... More >>r AJCC V8|Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC V8|Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC V8|Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC V8|Locally Advanced Malignant Solid Neoplasm|Locally Advanced Melanoma|Locally Advanced Primary Malignant Central Nervous System Neoplasm|Locally Advanced Sarcoma|Metastatic Malignant Solid Neoplasm|Metastatic Melanoma|Metastatic Primary Malignant Central Nervous System Neoplasm|Metastatic Sarcoma|Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC V8|Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC V8|Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC V8|Postneoadjuvant Therapy Stage IV Gastroesophageal Junction Adenocarcinoma AJCC V8|Postneoadjuvant Therapy Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC V8|Postneoadjuvant Therapy Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC V8|Prognostic Stage IIIC Breast Cancer AJCC V8|Prognostic Stage IV Breast Cancer AJCC V8|Stage IIIC Colorectal Cancer AJCC V8|Stage IIIC Lung Cancer AJCC V8|Stage IV Colorectal Cancer AJCC V8|Stage IV Lung Cancer AJCC V8|Stage IVA Colorectal Cancer AJCC V8|Stage IVA Lung Cancer AJCC V8|Stage IVB Colorectal Cancer AJCC V8|Stage IVB Lung Cancer AJCC V8|Stage IVC Colorectal Cancer AJCC V8 Less << | PHASE2 | RECRUITING | 2025-02-03 | M D Anderson Cancer Center, Ho... More >>uston, Texas, 77030, United States Less << |
NCT03862885 | GIST | APPROVED_FOR_MARKETING | - | - | |
NCT06765915 | AML, Adult | PHASE2 | NOT_YET_RECRUITING | 2028-02-01 | Ruijin Hospital of Shanghai Ji... More >>aotong University, Shanghai, Shanghai, China Less << |
NCT04825574 | Gastrointestinal Stromal Tumor... More >>s Less << | PHASE4 | COMPLETED | 2023-11-23 | Gustave Roussy Cancer Campus G... More >>rand Paris Institut de Cancerologie Gustave-Roussy, Villejuif, Val-de-Marne, 94800, France Less << |
NCT05821738 | Core Binding Factor Acute Myel... More >>oid Leukemia|KIT Mutation-Related Tumors Less << | PHASE2 | RECRUITING | 2025-12-31 | First Affiliated Hospital of S... More >>oochow University, Suzhou, Jiangsu, 215000, China Less << |
NCT04714086 | Solid Tumors | NO_LONGER_AVAILABLE | - | - | |
NCT06748001 | Mastocytosis, Systemic | PHASE4 | RECRUITING | 2027-12-31 | Universitair Ziekenhuis Antwer... More >>pen (UZA), Edegem, 2650, Belgium|Erasmus Medisch Centrum, Rotterdam, 3015, Netherlands|Oslo University Hospital, Oslo, 0424, Norway Less << |
Tags: Avapritinib | BLU-285 | BLU285 | BLU 285 | c-Kit Inhibitor | PDGFR Inhibitor | SCFR Inhibitor | CD117 | Platelet-derived growth factor receptor | PDGFRA inhibitor | mutant kinases | antitumor activity | ABCB1 | ABCG2 | KIT D816V | PDGFRA mutations | GISTs | tyrosine kinase inhibitor | D816V mutation | 1703793-34-3
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :
Total Compounds: mg
The concentration of the dissolution solution you need to prepare is mg/mL