630-580-1088 sales@ambeed.com
Structure Search

List Search MOL Search Structure Search

0
Chemistry
Asymmetric Synthesis >>Chiral Building BlocksChiral Catalysts, Chiral Ligands and Chiral ReagentsChiral Resolution ReagentsCatalysis Chemistry >>Achiral Crown LigandsC-H ActivationCarbon-Donor LigandsChiral Crown LigandsCross-CouplingCross-Coupling Using Transition Metal CatalystsDACH or Trost LigandsDiketone LigandsHydrogenationChemical Biology >>Conjugation ChemistryGlycoscienceLinkers and CrosslinkersNucleic Acid ChemistryPEGylation
Peptide ChemistryPhotolabile Protecting GroupHeterocyclic Building Blocks >>Acridinium SeriesAliphatic HeterocyclesAromatic HeterocyclesAzetidinesBenzimidazolesBenzisoxazolesBenzodioxansBenzofuransBenzothiazolesInorganic reagents >>Inorganic reagentOrganic Building Blocks >>Acyl ChloridesAlcoholsAldehydesAliphatic Chain HydrocarbonsAliphatic Cyclic Hydrocarbons
AlkenylsAlkylsAlkynylsAmidesOrganometallic Reagents >>Grignard ReagentsOrganoarsenicOrganobismuthOrganoboronOrganogermaniumOrganolithiumOrganomercuryOrganosiliconOrganotinSpecialty Synthesis >>Enzyme-Mediated SynthesisFluorous SynthesisIonic LiquidsSolid Supported SynthesisStains and Dyes >>
Acid DyesAzoic DyesBasic DyesDirect DyesDisperse DyesDye IntermediatesMordant DyesOil DyesOther Stains and DyesSynthetic Reagents >>Acids and BasesC-C Bond FormationC-X Bond Formation (Halogen)C-X Bond Formation (Non-Halogen)Chelation and Complexation CompoundsCondensation AgentsCouplingDehydrating ReagentsFluorination Reagent
Pharmaceutical Intermediates
Analgesics >>BenzhydrocodoneBicifadineCapsaicinCelecoxibDebio-0827DexamethasoneElagolix SodiumEsketamine HydrochlorideIbuprofen sodiumAnesthetics >>CiprofolEsketamine HydrochlorideFospropofol Fospropofol DisodiumLevobupivacaine RemimazolamRemimazolam BesilateRemimazolam besylateRopivacaineAnti-Addiction Agents >>Kakonein
Lofexidine HydrochlorideVarenicline Anti-inflammatory Agents >>ApremilastAsunaprevirATB-346 RelatedBalsalazide BaricitinibBencycloquidium BromideBudesonideCefiderocol Sulfate TosylateCeftaroline Fosamil AcetateAntibacterials >>AFN-1252 RelatedAlatrofloxacin Bedaquiline FumarateBesifloxacin BrilacidinCaspofungin AcetateCefiderocol Sulfate TosylateCefilavancinCeftaroline Fosamil
Anticonvulsants >>BrivaracetamCannabidiolEscitalopram OxalateEslicarbazepine Acetate RelatedFosphenytoinGabapentin EnacarbilJNJ-10234094LacosamideLevetiracetam RelatedAntidementia Agents >>Azeliragon RelatedDavunetideDonepezil HydrochlorideDonepezil RelatedEnsaculinFlorbetaben Flortaucipir F 18Flutemetamol IdalopirdineAntidepressants >>4-Chlorokynurenine
AgomelatineAgomelatine RelatedAllopregnanolone RelatedAmibegronAmitifadineAripiprazole RelatedBasimglurantBefloxatoneAntiemetics >>AprepitantAprepitant RelatedDolasetron RelatedDolasetron Mesylate HydrateFosaprepitant DimeglumineFosaprepitant RelatedOlanzapinePalonosetron RelatedPalonosetron HydrochlorideAntifungals >>Anidulafungin RelatedCabotegravirMore >>
Inhibitors/Agonists
ADC >>ADC LinkerADC Linker with PayloadADC ToxinAnti-infection >>3CLproAntibacterialAntifungalAntiparasiticAntiprotozoalAntiviralBVDVCMVDengue VirusApoptosis >>Apoptosis InducerBcl-2c-Mycc-RETC/EBPCARDCaspase
DAPKIAPAutophagy >>AutophagyLC3LRRK2LysosomemitoNEETPPTSPHKTFEBULKBiochemical Reagent >>Cationic & Neutral LipidsDendrimersDye ReagentIntermediate and OthersCell Cycle >>APCAurora KinaseBUBCasein Kinase
Cdc25CDKChkCRM1DHFRCytoskeleton >>ActinArp2/3 ComplexCytoplasmic dyneinDynaminFAKFilamin-AGap JunctionIntegrinMicrotubule/TubulinDNA Damage >>AP endonucleaseATAD5ATM/ATRBRCADNA Alkylator/CrosslinkerMore >>
Material Science
Aggregation-Induced Emission >>Other AIE BlocksTetraphenylethylene SeriesElectronic Materials >>Battery MaterialsDye-Sensitized Solar Cell (DSSC) MaterialsElectronic MaterialLiquid Crystal (LC) MaterialsMolecular ConductorsOrganic Light-Emitting Diode (OLED) MaterialsOrganic Solar Cell (OPV) MaterialsOrganic Transistor (OFET) MaterialsPerovskite Solar Cell (PSC) MaterialsMagnetic Materials >>Magnetic Ionic LiquidsMagnetic MaterialMagnetic Metal Complexes Organic Radicals Material Building Blocks >>Ligands for Functional Metal ComplexesLiquid Crystal (LC) Building BlocksPhthalocyanine Building BlocksPolymer and Macromolecule Semiconductor Building BlocksSmall Molecule Semiconductor Building BlocksSolubility Enhancing Reagents Supramolecular Host Materials MOF Ligands >>
Carboxylic MOF ligandsHalogen seriesMOF ligands of nitrogenous carboxylic acidsNitrogen containing MOF ligandsOrganic frame monomer blockOther MOF ligandsPorphyrin seriesTwo dimensional MOF ligandsNanomaterials >>Carbon NanomaterialsCeramic MembranesDendrimersGold NanoparticlesIron Oxide NanoparticlesMaterials by ApplicationMesoporous MaterialsMetals and Metal AlloysNano Minerals: NanoclaysOLED Materials >>DopantHostHTMOther OLED related metarialsOptical Materials >>Coumarin DyesCyanine and Squarylium DyesDCM Dyes
Dipyrromethene DyesFluorescence MaterialsFluorescent ProbesHeat and Pressure Sensitive DyesNear-Infrared (NIR) DyesOrganic Non-Linear Optical (NLO) MaterialsOrganic monomer of COF >>Aldehyde based COF monomerAlkynyl COF monomerAmino COF monomerBoric acid COF monomerCyano COF monomerMultifunctional COF monomerOther COF monomerTriphene seriesOrganic Pigments >>Organic PigmentOther Materials >>Mateial OtherPolymer Science >>MonomersPolymer AdditivesPolymerization ReagentsPolymersResins
Life Science
ADC-linkers >>ADC-linkerAmino Acids >>Amino AcidAmino Acid DerivativesAnalytical Science >>Stable IsotopesAPIs >>API
DNA/RNA >>Nucleosides and NucleotidesEnzymes >>EnzymeOther Life Science >>CRISPR/Cas9eIFIRE1Neuronal Signaling
Sigma ReceptorPeptides >>PeptideStandard Substrates >>Standard SubstrateSteroids >>Other Steroids
Contact Us
Home Cart 0 Sign in  
X
Chemistry
Organic Building Blocks
Aryls
2,3-Dichloro-4-methylbenzaldehyde
Chemistry
Organic Building Blocks
Aryls
Chlorides Aldehydes Benzene Compounds

[ CAS No. 170879-71-7 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
3d Animation Molecule Structure of 170879-71-7
Chemical Structure| 170879-71-7
Chemical Structure| 170879-71-7
Structure of 170879-71-7 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Bulk Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 100K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 170879-71-7 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 170879-71-7 ]

SDS Specification
Alternatived Products of [ 170879-71-7 ]

Product Details of [ 170879-71-7 ]

CAS No. :170879-71-7 MDL No. :MFCD18917081
Formula : C8H6Cl2O Boiling Point : -
Linear Structure Formula :- InChI Key :FYLGSVWGWPLXGK-UHFFFAOYSA-N
M.W :189.04 g/mol Pubchem ID :20237387
Synonyms :

Safety of [ 170879-71-7 ]

Signal Word:Danger Class:8
Precautionary Statements:P501-P273-P260-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405 UN#:1759
Hazard Statements:H314-H412 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 170879-71-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 170879-71-7 ]

[ 170879-71-7 ] Synthesis Path-Downstream   1~22

  • 1
  • [ 4478-63-1 ]
  • [ 68-12-2 ]
  • [ 170879-71-7 ]
YieldReaction ConditionsOperation in experiment
45% With trichlorophosphate RT, 30 min, heating, 4-4.5 h;
Reference： [1]Megati, Sreenivasulu; Rao, Krishna G. S. [Tetrahedron Letters, 1995, vol. 36, # 32, p. 5819 - 5822]
  • 2
  • [ 21889-89-4 ]
  • [ 68-12-2 ]
  • [ 2951-10-2 ]
  • [ 170879-71-7 ]
YieldReaction ConditionsOperation in experiment
1: 11% 2: 19% With trichlorophosphate RT, 30 min, heating, 4-4.5 h;
Reference： [1]Megati, Sreenivasulu; Rao, Krishna G. S. [Tetrahedron Letters, 1995, vol. 36, # 32, p. 5819 - 5822]
  • 3
  • [ 170879-71-7 ]
  • [ 22483-09-6 ]
  • [ 1988726-46-0 ]
YieldReaction ConditionsOperation in experiment
13.0 g Stage #1: 2,3-dichloro-4-methyl-benzaldehyde; 2,2-dimethoxyethylamine In toluene for 2h; Dean-Stark; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h; N- [(2,3 -Dichloro-4-methyl-phenyl)methyl] -2,2-dimethoxy-ethanamine A solution of 13.0 g (68.8 mmol) of 2,3-dichloro-4-methyl-benzaldehyde and 8.76 g (82.5 mmol) of aminoacetaldehyde dimethyl acetal (CAS 22483-09-6) in 100 mL of toluene is stirred with a Dean-Stark trap under reflux for 2 h. The mixture is concentrated under vacuum to give the residue, which is dissolved in 100 mL of EtOH and 2.71g (70.4 mmol) of NaBH4 is added slowly at 0°C. The reaction mixture is stirred at 20°C for 2 h. 50 mL of H20 was added and the mixture is extracted with EA. Thecombined organic layers are dried over Na2504 and then concentrated under vacuum to afford 13.0 g of the residue as a yellow oil.MS (ESI+): 278.0 [M+H].
Reference： [1]Current Patent Assignee: BASILEA PHARM INT; BASILEA PHARMACEUTICA - WO2016/128465, 2016, A1 Location in patent: Page/Page column 220
  • 4
  • [ 170879-71-7 ]
  • [ 1988726-47-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: toluene / 2 h / Dean-Stark; Reflux 1.2: 2 h / 0 - 20 °C 2.1: pyridine / dichloromethane / 16 h / 20 °C
Reference： [1]Current Patent Assignee: BASILEA PHARM INT; BASILEA PHARMACEUTICA - WO2016/128465, 2016, A1
  • 5
  • [ 170879-71-7 ]
  • [ 1988726-48-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: toluene / 2 h / Dean-Stark; Reflux 1.2: 2 h / 0 - 20 °C 2.1: pyridine / dichloromethane / 16 h / 20 °C 3.1: aluminum (III) chloride / dichloromethane / 16 h / 0 - 20 °C
Reference： [1]Current Patent Assignee: BASILEA PHARM INT; BASILEA PHARMACEUTICA - WO2016/128465, 2016, A1
  • 6
  • [ 170879-71-7 ]
  • [ 1988726-49-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: toluene / 2 h / Dean-Stark; Reflux 1.2: 2 h / 0 - 20 °C 2.1: pyridine / dichloromethane / 16 h / 20 °C 3.1: aluminum (III) chloride / dichloromethane / 16 h / 0 - 20 °C 4.1: N-Bromosuccinimide; acetic acid / 3 h / 60 °C
Reference： [1]Current Patent Assignee: BASILEA PHARM INT; BASILEA PHARMACEUTICA - WO2016/128465, 2016, A1
  • 7
  • [ 170879-71-7 ]
  • [ 1988726-51-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: toluene / 2 h / Dean-Stark; Reflux 1.2: 2 h / 0 - 20 °C 2.1: pyridine / dichloromethane / 16 h / 20 °C 3.1: aluminum (III) chloride / dichloromethane / 16 h / 0 - 20 °C 4.1: N-Bromosuccinimide; acetic acid / 3 h / 60 °C 5.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 85 °C 5.2: 16 h / 20 °C
Reference： [1]Current Patent Assignee: BASILEA PHARM INT; BASILEA PHARMACEUTICA - WO2016/128465, 2016, A1
  • 8
  • [ 170879-71-7 ]
  • [ 1988726-52-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: toluene / 2 h / Dean-Stark; Reflux 1.2: 2 h / 0 - 20 °C 2.1: pyridine / dichloromethane / 16 h / 20 °C 3.1: aluminum (III) chloride / dichloromethane / 16 h / 0 - 20 °C 4.1: N-Bromosuccinimide; acetic acid / 3 h / 60 °C 5.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 85 °C 5.2: 16 h / 20 °C 6.1: tetrakis(triphenylphosphine) palladium(0); potassium phosphate / water; 1,4-dioxane / 16 h / 95 °C / Inert atmosphere
Reference： [1]Current Patent Assignee: BASILEA PHARM INT; BASILEA PHARMACEUTICA - WO2016/128465, 2016, A1
  • 9
  • [ 170879-71-7 ]
  • [ 1988723-78-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: toluene / 2 h / Dean-Stark; Reflux 1.2: 2 h / 0 - 20 °C 2.1: pyridine / dichloromethane / 16 h / 20 °C 3.1: aluminum (III) chloride / dichloromethane / 16 h / 0 - 20 °C 4.1: N-Bromosuccinimide; acetic acid / 3 h / 60 °C 5.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 85 °C 5.2: 16 h / 20 °C 6.1: tetrakis(triphenylphosphine) palladium(0); potassium phosphate / water; 1,4-dioxane / 16 h / 95 °C / Inert atmosphere 7.1: t-BuBrettPhos; ([(2-di-tert-butylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1‘-biphenyl)-2-(2‘-amino-1,1‘-biphenyl)]palladium(II) methanesulfonate) / 1,4-dioxane / 0.25 h / 120 °C / Microwave irradiation
Reference： [1]Current Patent Assignee: BASILEA PHARM INT; BASILEA PHARMACEUTICA - WO2016/128465, 2016, A1
  • 10
  • [ 170879-71-7 ]
  • [ 1988723-79-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: toluene / 2 h / Dean-Stark; Reflux 1.2: 2 h / 0 - 20 °C 2.1: pyridine / dichloromethane / 16 h / 20 °C 3.1: aluminum (III) chloride / dichloromethane / 16 h / 0 - 20 °C 4.1: N-Bromosuccinimide; acetic acid / 3 h / 60 °C 5.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 85 °C 5.2: 16 h / 20 °C 6.1: tetrakis(triphenylphosphine) palladium(0); potassium phosphate / water; 1,4-dioxane / 16 h / 95 °C / Inert atmosphere 7.1: hydrogenchloride / ethyl acetate / 16 h / 0 - 20 °C
Reference： [1]Current Patent Assignee: BASILEA PHARM INT; BASILEA PHARMACEUTICA - WO2016/128465, 2016, A1
  • 11
  • [ 170879-71-7 ]
  • [ 2244453-83-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium / methanol; dichloromethane / -78 - 20 °C 2: o-xylene / 0.83 h / 130 °C
Reference： [1]Arnhof, Heribert; Bader, Gerd; Bruchhaus, Jens; Burkard, Michelle; Ciftci, Tuncay; Dahmann, Georg; Du, Alicia; Ettmayer, Peter; Fett, Thomas N.; Garavel, Géraldine; Gerstberger, Thomas; Haering, Daniela; Harrer, Christoph; Hofbauer, Karin S.; Kessler, Dirk; Kousek, Roland; Li, Dongyang; Li, Yali; Lv, Xiaobing; Martinelli, Paola; Mayer, Moriz; McConnell, Darryl B.; Mischerikow, Nikolai; Mitzner, Sophie; Pearson, Mark; Peric-Simov, Biljana; Quant, Jens; Rinnenthal, Joerg; Rumpel, Klaus; Savarese, Fabio; Scherbantin, Yvonne; Schnitzer, Renate; Scholz, Guido; Schrenk, Andreas; Sharps, Bernadette; Sommergruber, Wolfgang; Treu, Matthias; Weinstabl, Harald; Wolkerstorfer, Bernhard; Zahn, Stephan K.; Zhang, Xuechun; Zoephel, Andreas [Journal of Medicinal Chemistry, 2019]
  • 12
  • [ 170879-71-7 ]
  • [ 2244453-95-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: sodium / methanol; dichloromethane / -78 - 20 °C 2: o-xylene / 0.83 h / 130 °C 3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C
Reference： [1]Arnhof, Heribert; Bader, Gerd; Bruchhaus, Jens; Burkard, Michelle; Ciftci, Tuncay; Dahmann, Georg; Du, Alicia; Ettmayer, Peter; Fett, Thomas N.; Garavel, Géraldine; Gerstberger, Thomas; Haering, Daniela; Harrer, Christoph; Hofbauer, Karin S.; Kessler, Dirk; Kousek, Roland; Li, Dongyang; Li, Yali; Lv, Xiaobing; Martinelli, Paola; Mayer, Moriz; McConnell, Darryl B.; Mischerikow, Nikolai; Mitzner, Sophie; Pearson, Mark; Peric-Simov, Biljana; Quant, Jens; Rinnenthal, Joerg; Rumpel, Klaus; Savarese, Fabio; Scherbantin, Yvonne; Schnitzer, Renate; Scholz, Guido; Schrenk, Andreas; Sharps, Bernadette; Sommergruber, Wolfgang; Treu, Matthias; Weinstabl, Harald; Wolkerstorfer, Bernhard; Zahn, Stephan K.; Zhang, Xuechun; Zoephel, Andreas [Journal of Medicinal Chemistry, 2019]
  • 13
  • [ 170879-71-7 ]
  • [ 2244454-05-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: sodium / methanol; dichloromethane / -78 - 20 °C 2: o-xylene / 0.83 h / 130 °C 3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C 4: sodium hydroxide; water / methanol / 1 h / 65 °C
Reference： [1]Arnhof, Heribert; Bader, Gerd; Bruchhaus, Jens; Burkard, Michelle; Ciftci, Tuncay; Dahmann, Georg; Du, Alicia; Ettmayer, Peter; Fett, Thomas N.; Garavel, Géraldine; Gerstberger, Thomas; Haering, Daniela; Harrer, Christoph; Hofbauer, Karin S.; Kessler, Dirk; Kousek, Roland; Li, Dongyang; Li, Yali; Lv, Xiaobing; Martinelli, Paola; Mayer, Moriz; McConnell, Darryl B.; Mischerikow, Nikolai; Mitzner, Sophie; Pearson, Mark; Peric-Simov, Biljana; Quant, Jens; Rinnenthal, Joerg; Rumpel, Klaus; Savarese, Fabio; Scherbantin, Yvonne; Schnitzer, Renate; Scholz, Guido; Schrenk, Andreas; Sharps, Bernadette; Sommergruber, Wolfgang; Treu, Matthias; Weinstabl, Harald; Wolkerstorfer, Bernhard; Zahn, Stephan K.; Zhang, Xuechun; Zoephel, Andreas [Journal of Medicinal Chemistry, 2019]
  • 14
  • [ 170879-71-7 ]
  • [ 2369982-34-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: sodium / methanol; dichloromethane / -78 - 20 °C 2.1: o-xylene / 0.83 h / 130 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C 4.1: sodium hydroxide; water / methanol / 1 h / 65 °C 5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.08 h / 20 °C 5.2: 1.5 h / 20 °C 6.1: sodium hydroxide; water / methanol / 1 h / 80 °C
Reference： [1]Arnhof, Heribert; Bader, Gerd; Bruchhaus, Jens; Burkard, Michelle; Ciftci, Tuncay; Dahmann, Georg; Du, Alicia; Ettmayer, Peter; Fett, Thomas N.; Garavel, Géraldine; Gerstberger, Thomas; Haering, Daniela; Harrer, Christoph; Hofbauer, Karin S.; Kessler, Dirk; Kousek, Roland; Li, Dongyang; Li, Yali; Lv, Xiaobing; Martinelli, Paola; Mayer, Moriz; McConnell, Darryl B.; Mischerikow, Nikolai; Mitzner, Sophie; Pearson, Mark; Peric-Simov, Biljana; Quant, Jens; Rinnenthal, Joerg; Rumpel, Klaus; Savarese, Fabio; Scherbantin, Yvonne; Schnitzer, Renate; Scholz, Guido; Schrenk, Andreas; Sharps, Bernadette; Sommergruber, Wolfgang; Treu, Matthias; Weinstabl, Harald; Wolkerstorfer, Bernhard; Zahn, Stephan K.; Zhang, Xuechun; Zoephel, Andreas [Journal of Medicinal Chemistry, 2019]
  • 15
  • [ 170879-71-7 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: sodium / methanol; dichloromethane / -78 - 20 °C 2.1: o-xylene / 0.83 h / 130 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C 4.1: sodium hydroxide; water / methanol / 1 h / 65 °C 5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.08 h / 20 °C 5.2: 1.5 h / 20 °C
Reference： [1]Arnhof, Heribert; Bader, Gerd; Bruchhaus, Jens; Burkard, Michelle; Ciftci, Tuncay; Dahmann, Georg; Du, Alicia; Ettmayer, Peter; Fett, Thomas N.; Garavel, Géraldine; Gerstberger, Thomas; Haering, Daniela; Harrer, Christoph; Hofbauer, Karin S.; Kessler, Dirk; Kousek, Roland; Li, Dongyang; Li, Yali; Lv, Xiaobing; Martinelli, Paola; Mayer, Moriz; McConnell, Darryl B.; Mischerikow, Nikolai; Mitzner, Sophie; Pearson, Mark; Peric-Simov, Biljana; Quant, Jens; Rinnenthal, Joerg; Rumpel, Klaus; Savarese, Fabio; Scherbantin, Yvonne; Schnitzer, Renate; Scholz, Guido; Schrenk, Andreas; Sharps, Bernadette; Sommergruber, Wolfgang; Treu, Matthias; Weinstabl, Harald; Wolkerstorfer, Bernhard; Zahn, Stephan K.; Zhang, Xuechun; Zoephel, Andreas [Journal of Medicinal Chemistry, 2019]
  • 16
  • [ 170879-71-7 ]
  • [ 2244452-08-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: sodium / methanol; dichloromethane / -78 - 20 °C 2.1: o-xylene / 0.83 h / 130 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C 4.1: sodium hydroxide; water / methanol / 1 h / 65 °C 5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.17 h / 20 °C 5.2: 1 h / 20 °C 6.1: 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; palladium diacetate; catacxium A; triethylamine / isopropyl alcohol / 1 h / 75 °C 6.2: 2 h / 20 °C 7.1: sodium hydroxide; water / acetonitrile / 0.5 h / 70 °C
Reference： [1]Arnhof, Heribert; Bader, Gerd; Bruchhaus, Jens; Burkard, Michelle; Ciftci, Tuncay; Dahmann, Georg; Du, Alicia; Ettmayer, Peter; Fett, Thomas N.; Garavel, Géraldine; Gerstberger, Thomas; Haering, Daniela; Harrer, Christoph; Hofbauer, Karin S.; Kessler, Dirk; Kousek, Roland; Li, Dongyang; Li, Yali; Lv, Xiaobing; Martinelli, Paola; Mayer, Moriz; McConnell, Darryl B.; Mischerikow, Nikolai; Mitzner, Sophie; Pearson, Mark; Peric-Simov, Biljana; Quant, Jens; Rinnenthal, Joerg; Rumpel, Klaus; Savarese, Fabio; Scherbantin, Yvonne; Schnitzer, Renate; Scholz, Guido; Schrenk, Andreas; Sharps, Bernadette; Sommergruber, Wolfgang; Treu, Matthias; Weinstabl, Harald; Wolkerstorfer, Bernhard; Zahn, Stephan K.; Zhang, Xuechun; Zoephel, Andreas [Journal of Medicinal Chemistry, 2019]
  • 17
  • [ 170879-71-7 ]
  • [ 2244452-09-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1.1: sodium / methanol; dichloromethane / -78 - 20 °C 2.1: o-xylene / 0.83 h / 130 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C 4.1: sodium hydroxide; water / methanol / 1 h / 65 °C 5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.17 h / 20 °C 5.2: 1 h / 20 °C 6.1: 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; palladium diacetate; catacxium A; triethylamine / isopropyl alcohol / 1 h / 75 °C 6.2: 2 h / 20 °C 7.1: sodium hydroxide; water / acetonitrile / 0.5 h / 70 °C
Reference： [1]Arnhof, Heribert; Bader, Gerd; Bruchhaus, Jens; Burkard, Michelle; Ciftci, Tuncay; Dahmann, Georg; Du, Alicia; Ettmayer, Peter; Fett, Thomas N.; Garavel, Géraldine; Gerstberger, Thomas; Haering, Daniela; Harrer, Christoph; Hofbauer, Karin S.; Kessler, Dirk; Kousek, Roland; Li, Dongyang; Li, Yali; Lv, Xiaobing; Martinelli, Paola; Mayer, Moriz; McConnell, Darryl B.; Mischerikow, Nikolai; Mitzner, Sophie; Pearson, Mark; Peric-Simov, Biljana; Quant, Jens; Rinnenthal, Joerg; Rumpel, Klaus; Savarese, Fabio; Scherbantin, Yvonne; Schnitzer, Renate; Scholz, Guido; Schrenk, Andreas; Sharps, Bernadette; Sommergruber, Wolfgang; Treu, Matthias; Weinstabl, Harald; Wolkerstorfer, Bernhard; Zahn, Stephan K.; Zhang, Xuechun; Zoephel, Andreas [Journal of Medicinal Chemistry, 2019]
  • 18
  • [ 170879-71-7 ]
  • [ 2244451-48-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: sodium / methanol; dichloromethane / -78 - 20 °C 2.1: o-xylene / 0.83 h / 130 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C 4.1: sodium hydroxide; water / methanol / 1 h / 65 °C 5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.17 h / 20 °C 5.2: 1 h / 20 °C 6.1: 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; palladium diacetate; catacxium A; triethylamine / isopropyl alcohol / 1 h / 75 °C 6.2: 2 h / 20 °C
Reference： [1]Arnhof, Heribert; Bader, Gerd; Bruchhaus, Jens; Burkard, Michelle; Ciftci, Tuncay; Dahmann, Georg; Du, Alicia; Ettmayer, Peter; Fett, Thomas N.; Garavel, Géraldine; Gerstberger, Thomas; Haering, Daniela; Harrer, Christoph; Hofbauer, Karin S.; Kessler, Dirk; Kousek, Roland; Li, Dongyang; Li, Yali; Lv, Xiaobing; Martinelli, Paola; Mayer, Moriz; McConnell, Darryl B.; Mischerikow, Nikolai; Mitzner, Sophie; Pearson, Mark; Peric-Simov, Biljana; Quant, Jens; Rinnenthal, Joerg; Rumpel, Klaus; Savarese, Fabio; Scherbantin, Yvonne; Schnitzer, Renate; Scholz, Guido; Schrenk, Andreas; Sharps, Bernadette; Sommergruber, Wolfgang; Treu, Matthias; Weinstabl, Harald; Wolkerstorfer, Bernhard; Zahn, Stephan K.; Zhang, Xuechun; Zoephel, Andreas [Journal of Medicinal Chemistry, 2019]
  • 19
  • [ 170879-71-7 ]
  • [ 2244454-26-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: sodium / methanol; dichloromethane / -78 - 20 °C 2.1: o-xylene / 0.83 h / 130 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C 4.1: sodium hydroxide; water / methanol / 1 h / 65 °C 5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.17 h / 20 °C 5.2: 1 h / 20 °C
Reference： [1]Arnhof, Heribert; Bader, Gerd; Bruchhaus, Jens; Burkard, Michelle; Ciftci, Tuncay; Dahmann, Georg; Du, Alicia; Ettmayer, Peter; Fett, Thomas N.; Garavel, Géraldine; Gerstberger, Thomas; Haering, Daniela; Harrer, Christoph; Hofbauer, Karin S.; Kessler, Dirk; Kousek, Roland; Li, Dongyang; Li, Yali; Lv, Xiaobing; Martinelli, Paola; Mayer, Moriz; McConnell, Darryl B.; Mischerikow, Nikolai; Mitzner, Sophie; Pearson, Mark; Peric-Simov, Biljana; Quant, Jens; Rinnenthal, Joerg; Rumpel, Klaus; Savarese, Fabio; Scherbantin, Yvonne; Schnitzer, Renate; Scholz, Guido; Schrenk, Andreas; Sharps, Bernadette; Sommergruber, Wolfgang; Treu, Matthias; Weinstabl, Harald; Wolkerstorfer, Bernhard; Zahn, Stephan K.; Zhang, Xuechun; Zoephel, Andreas [Journal of Medicinal Chemistry, 2019]
  • 20
  • [ 170879-71-7 ]
  • [ 2244454-19-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: sodium / methanol; dichloromethane / -78 - 20 °C 2.1: o-xylene / 0.83 h / 130 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C 4.1: sodium hydroxide; water / methanol / 1 h / 65 °C 5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.17 h / 20 °C 5.2: 1 h / 20 °C
Reference： [1]Arnhof, Heribert; Bader, Gerd; Bruchhaus, Jens; Burkard, Michelle; Ciftci, Tuncay; Dahmann, Georg; Du, Alicia; Ettmayer, Peter; Fett, Thomas N.; Garavel, Géraldine; Gerstberger, Thomas; Haering, Daniela; Harrer, Christoph; Hofbauer, Karin S.; Kessler, Dirk; Kousek, Roland; Li, Dongyang; Li, Yali; Lv, Xiaobing; Martinelli, Paola; Mayer, Moriz; McConnell, Darryl B.; Mischerikow, Nikolai; Mitzner, Sophie; Pearson, Mark; Peric-Simov, Biljana; Quant, Jens; Rinnenthal, Joerg; Rumpel, Klaus; Savarese, Fabio; Scherbantin, Yvonne; Schnitzer, Renate; Scholz, Guido; Schrenk, Andreas; Sharps, Bernadette; Sommergruber, Wolfgang; Treu, Matthias; Weinstabl, Harald; Wolkerstorfer, Bernhard; Zahn, Stephan K.; Zhang, Xuechun; Zoephel, Andreas [Journal of Medicinal Chemistry, 2019]
  • 21
  • [ 170879-71-7 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: sodium / methanol; dichloromethane / -78 - 20 °C 2.1: o-xylene / 0.83 h / 130 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C 4.1: sodium hydroxide; water / methanol / 1 h / 65 °C 5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.17 h / 20 °C 5.2: 1 h / 20 °C 6.1: 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; palladium diacetate; catacxium A; triethylamine / isopropyl alcohol / 1 h / 75 °C 6.2: 2 h / 20 °C
Reference： [1]Arnhof, Heribert; Bader, Gerd; Bruchhaus, Jens; Burkard, Michelle; Ciftci, Tuncay; Dahmann, Georg; Du, Alicia; Ettmayer, Peter; Fett, Thomas N.; Garavel, Géraldine; Gerstberger, Thomas; Haering, Daniela; Harrer, Christoph; Hofbauer, Karin S.; Kessler, Dirk; Kousek, Roland; Li, Dongyang; Li, Yali; Lv, Xiaobing; Martinelli, Paola; Mayer, Moriz; McConnell, Darryl B.; Mischerikow, Nikolai; Mitzner, Sophie; Pearson, Mark; Peric-Simov, Biljana; Quant, Jens; Rinnenthal, Joerg; Rumpel, Klaus; Savarese, Fabio; Scherbantin, Yvonne; Schnitzer, Renate; Scholz, Guido; Schrenk, Andreas; Sharps, Bernadette; Sommergruber, Wolfgang; Treu, Matthias; Weinstabl, Harald; Wolkerstorfer, Bernhard; Zahn, Stephan K.; Zhang, Xuechun; Zoephel, Andreas [Journal of Medicinal Chemistry, 2019]
  • 22
  • [ 1816-92-8 ]
  • [ 170879-71-7 ]
  • [ 2369981-68-8 ]
YieldReaction ConditionsOperation in experiment
82% With sodium In methanol; dichloromethane at -78 - 20℃;
Reference： [1]Arnhof, Heribert; Bader, Gerd; Bruchhaus, Jens; Burkard, Michelle; Ciftci, Tuncay; Dahmann, Georg; Du, Alicia; Ettmayer, Peter; Fett, Thomas N.; Garavel, Géraldine; Gerstberger, Thomas; Haering, Daniela; Harrer, Christoph; Hofbauer, Karin S.; Kessler, Dirk; Kousek, Roland; Li, Dongyang; Li, Yali; Lv, Xiaobing; Martinelli, Paola; Mayer, Moriz; McConnell, Darryl B.; Mischerikow, Nikolai; Mitzner, Sophie; Pearson, Mark; Peric-Simov, Biljana; Quant, Jens; Rinnenthal, Joerg; Rumpel, Klaus; Savarese, Fabio; Scherbantin, Yvonne; Schnitzer, Renate; Scholz, Guido; Schrenk, Andreas; Sharps, Bernadette; Sommergruber, Wolfgang; Treu, Matthias; Weinstabl, Harald; Wolkerstorfer, Bernhard; Zahn, Stephan K.; Zhang, Xuechun; Zoephel, Andreas [Journal of Medicinal Chemistry, 2019]

Tags: 170879-71-7 synthesis path| 170879-71-7 SDS| 170879-71-7 COA| 170879-71-7 purity| 170879-71-7 application| 170879-71-7 NMR| 170879-71-7 COA| 170879-71-7 structure

Related Products
Historical Records

Related Functional Groups of
[ 170879-71-7 ]

Aryls

Chemical Structure| 6334-18-5

[ 6334-18-5 ]

2,3-Dichlorobenzaldehyde

Similarity: 1.00

Chemical Structure| 1803824-18-1

[ 1803824-18-1 ]

2,3-Dichloro-5-methylbenzaldehyde

Similarity: 1.00

Chemical Structure| 35696-87-8

[ 35696-87-8 ]

2,4,5-Trichlorobenzaldehyde

Similarity: 0.97

Chemical Structure| 6334-18-5

[ 6334-18-5 ]

2,3-Dichlorobenzaldehyde

Similarity: 1.00

Chemical Structure| 1803824-18-1

[ 1803824-18-1 ]

2,3-Dichloro-5-methylbenzaldehyde

Similarity: 1.00

Chlorides

Chemical Structure| 6334-18-5

[ 6334-18-5 ]

2,3-Dichlorobenzaldehyde

Similarity: 1.00

Chemical Structure| 1803824-18-1

[ 1803824-18-1 ]

2,3-Dichloro-5-methylbenzaldehyde

Similarity: 1.00

Chemical Structure| 35696-87-8

[ 35696-87-8 ]

2,4,5-Trichlorobenzaldehyde

Similarity: 0.97

Chemical Structure| 6334-18-5

[ 6334-18-5 ]

2,3-Dichlorobenzaldehyde

Similarity: 1.00

Chemical Structure| 1803824-18-1

[ 1803824-18-1 ]

2,3-Dichloro-5-methylbenzaldehyde

Similarity: 1.00

Aldehydes

Chemical Structure| 6334-18-5

[ 6334-18-5 ]

2,3-Dichlorobenzaldehyde

Similarity: 1.00

Chemical Structure| 1803824-18-1

[ 1803824-18-1 ]

2,3-Dichloro-5-methylbenzaldehyde

Similarity: 1.00

Chemical Structure| 35696-87-8

[ 35696-87-8 ]

2,4,5-Trichlorobenzaldehyde

Similarity: 0.97

Chemical Structure| 6334-18-5

[ 6334-18-5 ]

2,3-Dichlorobenzaldehyde

Similarity: 1.00

Chemical Structure| 1803824-18-1

[ 1803824-18-1 ]

2,3-Dichloro-5-methylbenzaldehyde

Similarity: 1.00