[ CAS No. 170879-71-7 ]

Name: 170879-71-7|2,3-Dichloro-4-methylbenzaldehyde|97%
Brand: Ambeed
SKU: A490922
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3d Animation Molecule Structure of 170879-71-7

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Quality Control of [ 170879-71-7 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 170879-71-7 ]

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Alternatived Products of [ 170879-71-7 ]

Product Details of [ 170879-71-7 ]

CAS No. :	170879-71-7	MDL No. :	MFCD18917081
Formula :	C₈H₆Cl₂O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	189.04 g/mol	Pubchem ID :	-
Synonyms :

Safety of [ 170879-71-7 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P501-P273-P260-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405	UN#:	1759
Hazard Statements:	H314-H412	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 170879-71-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 170879-71-7 ]

[ 170879-71-7 ] Synthesis Path-Downstream 1~22

1
[ 4478-63-1 ]
[ 68-12-2 ]
[ 170879-71-7 ]

Yield	Reaction Conditions	Operation in experiment
45%	With trichlorophosphate RT, 30 min, heating, 4-4.5 h;

Reference： [1]Megati, Sreenivasulu; Rao, Krishna G. S. [Tetrahedron Letters, 1995, vol. 36, # 32, p. 5819 - 5822]

2
[ 21889-89-4 ]
[ 68-12-2 ]
[ 2951-10-2 ]
[ 170879-71-7 ]

Yield	Reaction Conditions	Operation in experiment
1: 11% 2: 19%	With trichlorophosphate RT, 30 min, heating, 4-4.5 h;

Reference： [1]Megati, Sreenivasulu; Rao, Krishna G. S. [Tetrahedron Letters, 1995, vol. 36, # 32, p. 5819 - 5822]

3
[ 170879-71-7 ]
[ 22483-09-6 ]
[ 1988726-46-0 ]

Yield	Reaction Conditions	Operation in experiment
13.0 g	Stage #1: 2,3-dichloro-4-methyl-benzaldehyde; 2,2-dimethoxyethylamine In toluene for 2h; Dean-Stark; Reflux; Stage #2: With sodium tetrahydroborate In ethanol at 0 - 20℃; for 2h;	N- [(2,3 -Dichloro-4-methyl-phenyl)methyl] -2,2-dimethoxy-ethanamine A solution of 13.0 g (68.8 mmol) of 2,3-dichloro-4-methyl-benzaldehyde and 8.76 g (82.5 mmol) of aminoacetaldehyde dimethyl acetal (CAS 22483-09-6) in 100 mL of toluene is stirred with a Dean-Stark trap under reflux for 2 h. The mixture is concentrated under vacuum to give the residue, which is dissolved in 100 mL of EtOH and 2.71g (70.4 mmol) of NaBH4 is added slowly at 0°C. The reaction mixture is stirred at 20°C for 2 h. 50 mL of H20 was added and the mixture is extracted with EA. Thecombined organic layers are dried over Na2504 and then concentrated under vacuum to afford 13.0 g of the residue as a yellow oil.MS (ESI+): 278.0 [M+H].

Reference： [1]Current Patent Assignee: BASILEA PHARM INT; BASILEA PHARMACEUTICA - WO2016/128465, 2016, A1 Location in patent: Page/Page column 220

4
[ 170879-71-7 ]
[ 1988726-47-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: toluene / 2 h / Dean-Stark; Reflux 1.2: 2 h / 0 - 20 °C 2.1: pyridine / dichloromethane / 16 h / 20 °C