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Chemical Structure| 173334-58-2 Chemical Structure| 173334-58-2

Structure of Aliskiren hemifumarate
CAS No.: 173334-58-2

Chemical Structure| 173334-58-2

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Aliskiren hemifumarate is an inhibitor of renin with IC50 value of 1.5 nM.

Synonyms: SPP 100 hemifumarate; CGP60536B hemifumarate; SPP 100

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Product Details of Aliskiren hemifumarate

CAS No. :173334-58-2
Formula : C64H110N6O16
M.W : 1219.59
SMILES Code : CC(C)[C@@H](CC1=CC=C(OC)C(OCCCOC)=C1)C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(NCC(C)(C)C(N)=O)=O.CC(C)[C@@H](CC2=CC=C(OC)C(OCCCOC)=C2)C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(NCC(C)(C)C(N)=O)=O.O=C(O)/C=C/C(O)=O
Synonyms :
SPP 100 hemifumarate; CGP60536B hemifumarate; SPP 100
MDL No. :MFCD10566724
InChI Key :KLRSDBSKUSSCGU-KRQUFFFQSA-N
Pubchem ID :6918427

Safety of Aliskiren hemifumarate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6J mice Diet-induced obesity model Subcutaneous osmotic pump 50 mg/kg Once daily for 6 weeks Aliskiren reduced body-weight gain, adipose pads and plasma leptin concentration, independent of the diet. In adipose tissue, local concentrations of Ang II were also reduced by aliskiren. PMC2765596

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.82mL

0.16mL

0.08mL

4.10mL

0.82mL

0.41mL

8.20mL

1.64mL

0.82mL

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