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Chemical Structure| 177167-53-2 Chemical Structure| 177167-53-2

Structure of 177167-53-2

Chemical Structure| 177167-53-2

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Product Details of [ 177167-53-2 ]

CAS No. :177167-53-2
Formula : C7H3Cl2IO
M.W : 300.91
SMILES Code : O=CC1=C(C=C(C=C1Cl)I)Cl
MDL No. :MFCD27946243
InChI Key :MXFZNBCNKBQFAR-UHFFFAOYSA-N
Pubchem ID :15811088

Safety of [ 177167-53-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P260-P264-P280-P305+P351+P338-P405-P501
Class:8
UN#:1759
Packing Group:

Application In Synthesis of [ 177167-53-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 177167-53-2 ]

[ 177167-53-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3032-81-3 ]
  • [ 68-12-2 ]
  • [ 177167-53-2 ]
YieldReaction ConditionsOperation in experiment
32% To a stirred solution of l,3-dichloro-5-iodobenzene (4.0 g, 14.6 mmol) in THF (30 mL), LDA (2.0 M in THF/heptane/ethylbenzene, 9.6 mL, 16.9 mmol) was added dropwise at -78 °C and stirred for 1 h at the same temperature. A solution of DMF (1.7 mL, 22.0 mmol) in THF (5 mL) was added slowly at -78 °C and stirred for 3 h. The reaction mixture was quenched with saturated NH4C1 (50 mL) and extracted with EtOAc (2 x 30 mL). The combined organic layers were washed with water (50 mL), brine (50 mL), dried over anhydrous Na2S04 and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel, 20percent EtOAc/hexane as eluent) to afford compound A35-1 (1.4 g, 32percent) as colorless oil.
 

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