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CAS No. : | 177490-82-3 | MDL No. : | MFCD09027198 |
Formula : | C8H9BO4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | VILXJXDXZGKJLU-UHFFFAOYSA-N |
M.W : | 179.97 | Pubchem ID : | 44119577 |
Synonyms : |
|
Num. heavy atoms : | 13 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.12 |
Num. rotatable bonds : | 3 |
Num. H-bond acceptors : | 4.0 |
Num. H-bond donors : | 2.0 |
Molar Refractivity : | 47.77 |
TPSA : | 66.76 Ų |
GI absorption : | High |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.99 cm/s |
Log Po/w (iLOGP) : | 0.0 |
Log Po/w (XLOGP3) : | 0.58 |
Log Po/w (WLOGP) : | -0.71 |
Log Po/w (MLOGP) : | 0.2 |
Log Po/w (SILICOS-IT) : | -0.87 |
Consensus Log Po/w : | -0.16 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -1.46 |
Solubility : | 6.17 mg/ml ; 0.0343 mol/l |
Class : | Very soluble |
Log S (Ali) : | -1.56 |
Solubility : | 5.01 mg/ml ; 0.0279 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -1.36 |
Solubility : | 7.8 mg/ml ; 0.0434 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 2.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.78 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1.011 kg | With sodium hydroxide In waterLarge scale | Under nitrogen, 1.5 kg of 4-methoxyphenylboronic acid was added to a 30 L glass reactor,20 liters of toluene and 1.17 kg of acetyl chloride was added after the reaction mixture was cooled to -10 ~ 0 ,Stir for 1 hour. Begin adding 267 g of anhydrous aluminum trichloride in batches, after the addition is completed, the temperature is raised to 80 ° C., and the mixture is kept under stirring until TLC shows that the reaction of raw materials is complete. The process takes about 3 to 5 hours. During this process, the solid of the reaction mixture gradually dissolves, followed by gradual solid precipitation. Add 2M aqueous sodium hydroxide solution quench, adjust PH = 11-12 so far. At this point the organic layer is separated and discarded. The aqueous layer was added 6M aqueous hydrochloric acid to adjust PH = 2, 15 liters of ethyl acetate extraction twice, the organic layer was combined, washed with saturated brine, the organic layer spin dry, beating with acetone / n-heptane to obtain white crystalline solid p-hydroxybenzene boronic acid 1.01 kg, 73percent yield, HPLCAmount: 99.1percent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate;PdCl2(PPh2(CH2)4PPh2); In N,N-dimethyl-formamide; toluene; at 80℃; for 12h; | 4-(5-(5-tert-butyl-2-methoxybenzamido)-2-methylpyridin-3-yl)phenyl acetate.; In a glass vial N-(5-bromo-6-methylpyridin-3-yl)-5-tert-butyl-2-methoxybenzamide, <strong>[177490-82-3]4-acetoxyphenylboronic acid</strong> (9 mg, 0.05 mmol) (obtained by the methods described above) (19 mg, 0.05mmol), K2CO3 (20 mg, 0.15 mmol). and Pd(dprhob)Cl2 (1.5 mg, 0.0025 mmol) was added. Anhydrous toluene (1 ml) and anhydrous DMF (1 ml) were then added. The reaction mix was purged with nitrogen and then sealed. The sealed tube was heated to 800C and stirred for 12 h. The reaction was concentrated and purified via LC-MS to yield 13 mg of product (CaIc. mass: 432, obs. mass: 433). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With pyridine; dmap; at 20℃; for 8h; | For compounds (75, 76, 84), the commercially available 4-hydroxyphenylboronic acid was treated was treated with Ac2O and DMAP in pyridine at RT for 8 hr to give the boronic acid acetic acid phenyl ester. This boronic acid was used at the Suzuki coupling stage in the synthesis of compounds (75, 76, 84). Deprotection occurred in situ due to during Suzuki coupling conditions (See Suzuki coupling conditions Example 1); |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | With copper diacetate; caesium carbonate; In dimethyl sulfoxide; at 28℃; for 30h; | General procedure: To a mixture of acetophenone oxime (1a, 135 mg, 1 mmol), Cu(OAc)2 (100 mg, 0.5 mmol), Cs2CO3 (325 mg, 1 mmol), aryl boronic acid (2a, 242 mg, 2 mmol) and 4 ml of DMSO was added in open atmosphere in a 50 ml round bottom flask. The mixture was stirred at room temperature and the progress was monitored by TLC. After completion of the reaction, the reaction mixture was quenched with dil. NH4Cl-H2O solution and extracted with ethyl acetate (3 × 20 ml). Then the extract was washed with brine (2 × 20 ml) and dried over Na2SO4 and evaporated on reduced pressure. Residue was purified by silica gel chromatography (ethyl acetate-hexane: 1:9) to obtained the desired products. Thin-layer chromatography was carried out with Merck silica gel 60F254 plates. Products were characterized by 1H NMR, 13C NMR, FTIR spectroscopy and Mass spectroscopy. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65% | With copper diacetate; caesium carbonate; In dimethyl sulfoxide; at 28℃; for 22h; | General procedure: To a mixture of acetophenone oxime (1a, 135 mg, 1 mmol), Cu(OAc)2 (100 mg, 0.5 mmol), Cs2CO3 (325 mg, 1 mmol), aryl boronic acid (2a, 242 mg, 2 mmol) and 4 ml of DMSO was added in open atmosphere in a 50 ml round bottom flask. The mixture was stirred at room temperature and the progress was monitored by TLC. After completion of the reaction, the reaction mixture was quenched with dil. NH4Cl-H2O solution and extracted with ethyl acetate (3 × 20 ml). Then the extract was washed with brine (2 × 20 ml) and dried over Na2SO4 and evaporated on reduced pressure. Residue was purified by silica gel chromatography (ethyl acetate-hexane: 1:9) to obtained the desired products. Thin-layer chromatography was carried out with Merck silica gel 60F254 plates. Products were characterized by 1H NMR, 13C NMR, FTIR spectroscopy and Mass spectroscopy. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With palladium diacetate; triphenylphosphine; In ethanol; at 80℃; for 4h; | General procedure: All the 2-arylpyridines were synthesized through the couplingbetween corresponding arylboronic acids and 2-bromopyridines according toliterature procedures [1]: A mixture of Pd(OAc)2 (3 mol%),PPh3(6 mol%), arylboronic acid (7 mmol) and 2-bromopyridine (7mmol) were dissolved in ethanol (6 mL) in a 50 mL round-bottom flask and heatedto 80 oC for 4 h. Then the reaction mixture was diluted with ethylacetate (10 mL) and washed by distilled water (15 mL) for three times. Thecrude organic layers were collected and dried then the solvent was removed byevaporation. The product was obtained through column chromatographypurification with EtOAc/hexane (1/20). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58% | With tetrakis(triphenylphosphine) palladium(0); water; sodium carbonate; In 1,4-dioxane; for 14h;Reflux; | General procedure: To a 100 mL three-necked flask was added 1-iodo-2-((4-methoxyphenyl)ethynyl)benzene (334 mg, 1.0 mmol), 4-hydroxylphenylboronic acid (152 mg, 1.1 mmol), Pd(PPh3)4 (81 mg, 0.07 mmol), Na2CO3 (318 mg, 3.0 mmol), and solvent (25 mL, H2O:dioxane = 1:4). The mixture was refluxed and the reaction was completed after 12 h as monitored by TLC (eluent:petroleum ether:ethyl acetate = 80:1). The solvent was removed under reduced pressure. Purification by silica gel chromatography (eluent: petroleum ether:ethylacetate = 10:1?3:1) afforded 1g as an oil (225 mg, 75%); |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); silver orthophosphate; sodium acetate; triphenylphosphine; In N,N-dimethyl-formamide; at 150℃; for 0.166667h;Inert atmosphere; Microwave irradiation; | General procedure: A microwave reaction vial was charged with 1 or 6 (0.15 mmol, 1.0 equiv.), aryl iodide (0.17 mmol,1.1 equiv.), aryl boronic acid (0.18 mmol, 1.2 equiv.), CuI (0.0075 mmol, 5 mol %), NaOAc (0.45 mmol,3.0 equiv.), Pd(PPh3)4 (0.015 mmol, 10 mol %), Ag3PO4 (0.17 mmol, 1.1 equiv.) and DMF (3 mL).The reaction vial was sealed and exposed to microwave irradiation conditions with indicated timeand temperature (150 C, 10 min; representative conditions). The mixture was cooled to 25 C anddiluted with EtOAc (100 mL). Organic layer was washed with H2O (20 mL x 3) and brine (20 mL),then dried (Na2SO4), filtered and concentrated under reduced pressure. The crude residue was purifiedby column chromatography (silica gel, hexane:EtOAc) to yield 3-(diarylmethylene)oxindoles 3 or 7. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water;Inert atmosphere; Heating; | A compound represented by Formula (I-il-il), a compound represented by Formula (1-11-12), potassium carbonate, tetrahydrofuran, water, and tetrakis (triphenylphosphine) palladium (0) were put intoreaction container under a nitrogen atmosphere, followed by heating and stirring. After ordinary post-treatment was performed, purification was performed by column chromatography (silica gel) to obtain a compound represented by Formula (1-11-13). | |
8.6 g | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 8h;Inert atmosphere; Reflux; | In a nitrogen atmosphere, 10.0 g of the compound represented by the formula (I-70-11), 7.6 g of the compound represented by the formula (I-70-12), 8.7 of potassium carbonate, 50 mL of tetrahydrofuran, 25 mL of water and 0.5 g of tetrakis(triphenylphosphine)palladium(0) were put into a reactor, and heated under reflux for 8 hours. After poured into 5% hydrochloric acid, this was extracted with ethyl acetate and washed sequentially with water and salt water. Purification through column chromatography (silica gel, toluene/ethyl acetate) and recrystallization gave 8.6 g of the compound represented by the formula (I-70-13). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
59% | With 3,4,7,8-Tetramethyl-o-phenanthrolin; copper diacetate; lithium carbonate; N-fluorobis(benzenesulfon)imide; In N,N-dimethyl acetamide; benzene; at 20℃;Inert atmosphere; | General procedure: the dinitrogen ligand (5.8 mg, 0.024 mmol, 12 mol%), lithium carbonate (29.6 mg, 0.4 mmol, 2 equiv) and CuOAc (2.4 mg, 0.02 mmol, 10 mol%) in a 10 mL reaction tube under argon protection was dissolved in Benzene / DMA (4: 1,2 mL), stirred and the reaction turned to tan color. After 0.5h, the NFSI (0.50 mmol, 2.5 equiv), compound of formula II (0 · 40 mmol, 2.0 equiv) and compound of formula I (0 · 20 mmol, 1.0 equiv) were added sequentially in the reaction tube. The reaction solution turned from tan to blue color. Stirred the reaction for 4-24 hours. After the reaction was completed, the solvent benzene in the system was removed under reduced pressure and the residue was diluted with 20 mL of ethyl acetate and washed with water (10 mL of X 3). The organic phase was dried over anhydrous MgSO 4 and filtered. The filtrate was concentrated and then separated by flash column chromatography (petroleum ether / ethyl acetate) to give the title product |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Under nitrogen, 1.5 kg of 4-methoxyphenylboronic acid was added to a 30 L glass reactor,20 liters of toluene and 1.17 kg of acetyl chloride was added after the reaction mixture was cooled to -10 ~ 0 ,Stir for 1 hour. Begin adding 267 g of anhydrous aluminum trichloride in batches, after the addition is completed, the temperature is raised to 80 C., and the mixture is kept under stirring until TLC shows that the reaction of raw materials is complete. The process takes about 3 to 5 hours. During this process, the solid of the reaction mixture gradually dissolves, followed by gradual solid precipitation. Add 2M aqueous sodium hydroxide solution quench, adjust PH = 11-12 so far. At this point the organic layer is separated and discarded. The aqueous layer was added 6M aqueous hydrochloric acid to adjust PH = 2, 15 liters of ethyl acetate extraction twice, the organic layer was combined, washed with saturated brine, the organic layer spin dry, beating with acetone / n-heptane to obtain white crystalline solid p-hydroxybenzene boronic acid 1.01 kg, 73% yield, HPLCAmount: 99.1%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1.011 kg | With sodium hydroxide; In water;pH 11 - 12;Large scale; | Under nitrogen, 1.5 kg of <strong>[177490-82-3]4-methoxyphenylboronic acid</strong> was added to a 30 L glass reactor,20 liters of toluene and 1.17 kg of acetyl chloride was added after the reaction mixture was cooled to -10 ~ 0 ,Stir for 1 hour. Begin adding 267 g of anhydrous aluminum trichloride in batches, after the addition is completed, the temperature is raised to 80 C., and the mixture is kept under stirring until TLC shows that the reaction of raw materials is complete. The process takes about 3 to 5 hours. During this process, the solid of the reaction mixture gradually dissolves, followed by gradual solid precipitation. Add 2M aqueous sodium hydroxide solution quench, adjust PH = 11-12 so far. At this point the organic layer is separated and discarded. The aqueous layer was added 6M aqueous hydrochloric acid to adjust PH = 2, 15 liters of ethyl acetate extraction twice, the organic layer was combined, washed with saturated brine, the organic layer spin dry, beating with acetone / n-heptane to obtain white crystalline solid p-hydroxybenzene boronic acid 1.01 kg, 73% yield, HPLCAmount: 99.1%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | With copper(II) tetrafluoroborate hydrate; o-phenylenebis(diphenylphosphine); palladium(II) acetylacetonate; In 1,2-dimethoxyethane; at 20℃; for 40h;Inert atmosphere; | To an oven-dried round bottom flask containing a Teflon-coated magnetic stir bar under an Ar(g) atmosphere was added palladium(II) acetylacetonate (0.156 g, 0.506 mmol, 0.05 equiv), 1,2-bis(diphenylphosphino)benzene (0.23 1 g, 0.506 mmol, 0.05 equiv), copper(II) tetrafluoroborate hydrate (0.484 g, 2.025 mmol, 0.2 equiv),and <strong>[177490-82-3]4-acetoxyphenylboronic acid</strong> (2.789 g, 15.185 mmol, 1.5 equiv). To the mixture of solid materials was added anhydrous dimethoxyethane (60 mL). At this point, the solution appeared dark brown in color. To the stirring solution was then added 2-cyclohexen-1-one (1 mL, 10.122 mmol, 1.0 equiv) via syringe at room temperature. Within 5 minutes the solution had turned lime green in color. The solution was allowed to stir at room temperature for 16 hours. Based onLCMS and TLC analysis, it was determined that the reaction was incomplete and the following reagents were added: palladium(II) acetylacetonate (0.078 g, 0.256 mmol, 0.025 equiv), 1,2- bis(diphenylphosphino)benzene (0.115 g, 0.258 mmol, 0.025 equiv), copper(II) tetrafluoroborate hydrate (0.242 g, 1.020 mmol, 0.1 equiv), and <strong>[177490-82-3]4-acetoxyphenylboronic acid</strong> (1.394 g, 7.746 mmol, 0.75 equiv). The reaction was then allowed to stir at room temperature for an additional24 hours, at which point it was determined to be complete. The mixture was then concentrated under reduced pressure to yield a dark green oil. To this oil was added EtOAc (100 mL) followed by DI H20 (50 mL). Following separation of the layers, the organic layer was washed with additional DI H20 (50 mL). The organic layer was then filtered through a pad of Celite to remove all insoluble inorganic material. The pad was then rinsed with EtOAc (50 mL x 4). Theaqueous layer was extracted with EtOAc, and the resulting organic solution was filtered through the same pad of Celite. The pad was then again rinsed with EtOAc (50 mL x 2). The clear yellow solution was concentrated under reduced pressure to yield a yellow oil. The residue was then purified through flash column chromatography (220 g HP silica gel cartridge, 0-20% EtOAc/Hexanes, product eluted during 10-15% EtOAc/Hex) to yield Al (2.133 g, 91%) as afoamy solid. ?H NIVIR (400 IVIHz, CDC13) oe 7.22 (d, J 8.5 Hz, 2H), 7.04 (d, J 8.5 Hz, 2H),3.08-2.93 (m, 1H), 2.64-2.55 (m, 1H), 2.55-2.42 (m, 2H), 2.42-2.32 (m, 1H), 2.29 (s, 3H),2.19-2.03 (m, 2H), 1.90-1.70 (m, 2H); ?3C NIVIR (100 IVIFIz, CDC13) oe 210.8, 169.6, 149.2,141.8, 127.5, 121.7, 48.9, 44.1, 41.1, 32.7, 25.4, 21.1; MS (ESI) calculated forC,2H,502 [M+H] m/z 191.11, found 190.90. This mass corresponds to loss of the acetate, followed byprotonation of the phenoxide to yield the phenol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; at 70℃;Inert atmosphere; Sealed tube; | General procedure: A bromo-aldehyde (1 mmol), boronic acid (1.1e1.3 mmol), tetrakis(triphenylphosphine)palladium (0.05 mmol), potassium carbonate(3 mmol), water (3 ml), ethanol (4 ml) and toluene (4 ml)were added to a round-bottomed flask. The reaction mixture wasflushed with argon, sealed under septa and heated at 70 C overnight.After cooling to room temperature, water (50 ml) was added,and product was extracted with ethyl acetate (3 x 50 ml). Combinedextracts were washed with brine, dried with anhydrousmagnesium sulfate and evaporated under reduced pressure. Theproduct was purified by column chromatography on silica withchloroform or a mixture of methanol and chloroform (1:9). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
> 99% | With potassium carbonate; In water; toluene; at 60℃; for 2h; | General procedure: A suspension of bismacycle tosylate 1-OTs (1.0 equiv.; initial concentration = 0.05 M),K2CO3 (1.2 equiv.) and arylboronic acid (1.1 equiv.) in toluene/water (99:1,v/v) was stirred at 60 C for 2 h |
Tags: 177490-82-3 synthesis path| 177490-82-3 SDS| 177490-82-3 COA| 177490-82-3 purity| 177490-82-3 application| 177490-82-3 NMR| 177490-82-3 COA| 177490-82-3 structure
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P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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