Home Cart 0 Sign in  
X

[ CAS No. 178974-97-5 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
3d Animation Molecule Structure of 178974-97-5
Chemical Structure| 178974-97-5
Chemical Structure| 178974-97-5
Structure of 178974-97-5 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 178974-97-5 ]

Related Doc. of [ 178974-97-5 ]

Alternatived Products of [ 178974-97-5 ]

Product Details of [ 178974-97-5 ]

CAS No. :178974-97-5 MDL No. :MFCD02258905
Formula : C8H6F2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :KWLIGHXPUYUTBH-UHFFFAOYSA-N
M.W : 188.13 Pubchem ID :3780555
Synonyms :

Safety of [ 178974-97-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 178974-97-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 178974-97-5 ]

[ 178974-97-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 178974-97-5 ]
  • [ 194804-80-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: K2CO3; KOH / dimethylsulfoxide / 20 °C 2: BBr3 / CH2Cl2 / -30 - 0 °C
  • 2
  • [ 124-38-9 ]
  • [ 437-82-1 ]
  • [ 178974-97-5 ]
YieldReaction ConditionsOperation in experiment
EXAMPLE 4. SYNTHESIS OF theta-CYCLOPROPYL-T-FLUORO-S-METHOXY^H-isoTHiAzoLO^^-5]QUINOLINE-3,4-DIONE (4)[0248]; 9-Cyclopropyl-7-fluoro-8-methoxy-9H-isothiazolo[5,4-]quinoline-3,4-dione (4) is prepared in accordance with the following synthetic scheme.KNaSHM EPO <DP n="67"/>Step 1. Synthesis of 2,4-difluoro-3-methoxybenzoic acid (G).[0249] Lithium diisopropylamide (LDA) is formed by dropwise addition of n- butyllithium (1.6 M in hexanes, 39 mL, 62 mmol) to a stirred solution of diisopropylamine (9.1 mL, 65 mmol) in tetrahydrofuran (120 mL) at -78 C. The resulting solution is stirred at -78 0C for 5 min, -20 0C for 15 min, and then cooled again to -78 0C. This solution of LDA is added dropwise to a cooled (-78 0C) solution of l,3-difluoro-2-methoxybenzene (7.15 g, 50 mmol) in tetrahydrofuran (150 mL) over a period of 30 min. The reaction mixture is allowed to warm to -20 C, cooled to -78 C, and bubbled with carbon dioxide gas for ~30 min. The resulting mixture is acidified to pH ~2 by addition of a 2 M aqueous solution of hydrochloric acid, and the product is extracted with ethyl acetate (2 x 200 mL). The combined organic extracts are washed with brine (100 mL), dried over sodium sulfate, and evaporated under reduced pressure. The remaining residue is suspended in water (80 mL). The residue dissolved once the solution is adjusted to pH ~9 via addition of a 2 M aqueous solution of sodium hydroxide. This solution is washed with diethyl ether (2 x 30 mL) and acidified slowly to pH ~2 by addition of a 2 M aqueous solution of hydrochloric acid. The product is extracted with ethyl acetate (2 x 200 mL), and the combined organic extracts are washed with brine (100 mL), dried over sodium sulfate, and concentrated under reduced pressure to give G as a pale yellow solid. This product is used directly in the next synthetic step. 1H NMR (300 MHz, DMSO-4) S 3.93 (s, 3H, OCH3), 7.24 (ddd, JH_F = 10.5 Hz, JH-H = 9.0 Hz, JH_F = 2.0 Hz, IH, aromatic H-5), 7.62 (ddd, JH-H = 9.0 Hz, JH-F = 8.0 Hz, JH-F = 6.0 Hz, IH, aromatic H-6).
31.6 g 500 ml dry reaction flask, replaced with nitrogen gas, was added the compound (IV) 28.8 g of 100 ml of anhydrous 2-methyltetrahydrofuran, in the system under a nitrogen atmosphere, stirred and cooled to -78C, and slowly added dropwise 1.6M n-hexane solution of n-butyllithium in 185 ml. after completion of the dropwise addition, at -60 ~ -50C reaction was stirred for 2 hours.System cooling to -78C, carbon dioxide gas through for 5 hours after completion through ~ -40 -30C was stirred for 3 hours.The reaction system was allowed to warm to room temperature, 200 ml of water, stirred, and the organic solvent is recovered by distillation under reduced pressure, and the residue with 36% hydrochloric acid, filtered, and the filter cake washed with 100 ml of water, dried to give compound (V) 31.6 g.
Same Skeleton Products
Historical Records