BAY-876 | GLUT1 Inhibitor

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CAS No. :	1799753-84-6
Formula :	C₂₄H₁₆F₄N₆O₂
M.W :	496.42
SMILES Code :	O=C(C1=NC2=CC(F)=CC=C2C(C(NC3=C(C)N(CC4=CC=C(C#N)C=C4)N=C3C(F)(F)F)=O)=C1)N
MDL No. :	MFCD30377201
InChI Key :	BKLJDIJJOOQUFG-UHFFFAOYSA-N
Pubchem ID :	118191391

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302
Precautionary Statements:	P280-P305+P351+P338

HC11 cells	100 nM	24 hours	No obvious negative impact on GLUT1-normal cell populations	PMC10622423
MDA-MB-468	3 µM	72 hours	No significant changes in cell cycle observed	PMC7442809
MDA-MB-436	3 µM	72 hours	No significant changes in cell cycle observed	PMC7442809
DU145 cells	25 µM, 12 µM, 6 µM, 3 µM, 1.5 µM, 0.7 µM	0, 24, 48, 72 hours	To evaluate the inhibitory effect of BAY-876 on the viability of prostate cancer cells. Results showed that as the concentration of BAY-876 increased, cell activity gradually weakened. The IC50 of PC-3 at 24 h was 0.70 µM, and that of DU145 was 2.19 µM.	PMC11515740
PC-3 cells	25 µM, 12 µM, 6 µM, 3 µM, 1.5 µM, 0.7 µM	0, 24, 48, 72 hours	To evaluate the inhibitory effect of BAY-876 on the viability of prostate cancer cells. Results showed that as the concentration of BAY-876 increased, cell activity gradually weakened. The IC50 of PC-3 at 24 h was 0.70 µM, and that of DU145 was 2.19 µM.	PMC11515740
HaCaT cells	1 mM	2 hours	To evaluate the inhibitory effect of BAY-876 on Glu-4-ZnPc uptake in HaCaT cells	PMC11207564
Primary Gingival Keratinocytes	10 nM to 100 µM	24 hours	BAY-876 inhibited glucose uptake in primary gingival keratinocytes and reduced cell viability.	PMC11282258
FaDu	10 nM to 100 µM	24 hours	BAY-876 inhibited glucose uptake in FaDu cells, reduced cell viability and metabolism, and induced apoptosis.	PMC11282258
RPMI2650	10 nM to 100 µM	24 hours	BAY-876 inhibited glucose uptake in RPMI2650 cells, reduced cell viability and metabolism, and induced apoptosis.	PMC11282258
SCC47	10 nM to 100 µM	24 hours	BAY-876 inhibited glucose uptake in SCC47 cells, reduced cell viability and metabolism, and induced apoptosis.	PMC11282258
4T1 cells	100 nM	24 hours	Inhibited glycolysis activity in 4T1 cells, reduced PD-L1 glycosylation levels, and enhanced the binding affinity of aptPD-L1 to PD-L1	PMC10622423
HCT116 cells	1 μM	24 hours	BAY-876 inhibited the proliferation of HCT116 cells with an IC50 of 0.1–0.2 µmol/L.	PMC11010912
LS174T cells	1 μM	24 hours	BAY-876 inhibited the proliferation of LS174T cells with an IC50 of 0.1–0.2 µmol/L.	PMC11010912
HEK293 cells	0.05 μM, 1 μM, 5 μM	30 minutes	To assess the inhibitory effect of BAY-876 on glucose uptake mediated by GLUT1-6 and GLUT10. Results showed BAY-876 inhibited glucose uptake via GLUT1, GLUT3, GLUT4, GLUT6, and GLUT10, but not GLUT2.	PMC9776291
HEK293 cells	0.05 μM, 1 μM, 5 μM	30 minutes	To assess the ability of BAY-876 to inhibit hexose uptake via facilitative glucose transporters. Results showed BAY-876 inhibited glucose uptake via GLUT1, GLUT3, GLUT4, GLUT6, and GLUT10, but not GLUT2.	PMC9776291
HepG2 cells	1 μM	48 hours	BAY-876 significantly inhibited the expression of glycogenesis-related genes GBE1, GYS1, UGP2, and glycogenolysis-related gene PYGM	PMC10339511
Huh7 cells	1 μM	48 hours	BAY-876 significantly inhibited the expression of glycogenesis-related genes GBE1, GYS1, UGP2, and glycogenolysis-related gene PYGM	PMC10339511
Pt2377	25-400 nM	5 days	BAY-876 inhibited the proliferation of Pt2377 cells.	PMC9081236
LS174T	25-400 nM	5 days	BAY-876 inhibited the proliferation of LS174T cells.	PMC9081236
Hs 578T	3 µM	72 hours	Inhibited cell growth and proliferation, increased cell cycle arrest and apoptosis	PMC7442809
HCC1806	3 µM	72 hours	Inhibited cell growth and proliferation, increased cell cycle arrest and apoptosis	PMC7442809
UMRC6 cells	2 μM		Measure cell death, results showed BAY-876 significantly increased death in SLC7A11-high cells	PMC7194135
786-O cells	2 μM		Measure glucose uptake levels and NADP+/NADPH ratios, results showed BAY-876 significantly inhibited glucose uptake and increased NADP+/NADPH ratios	PMC7194135
GL261 cells	2 nM	72 hours	Inhibit GLUT1 expression and reduce lactate excretion	PMC11095231

Balb/c mice	4T1 tumor model	Intravenous injection	0.05 µg/mL/g	Once every two days for 21 days	Significantly inhibited tumor growth, reduced lactic acid and UDP-GlcNAc levels in the tumor microenvironment, and enhanced anti-tumor immune responses	PMC10622423
Mice	Muscle-specific GLUT1 knockout mice	In vitro muscle incubation	0.05 μM, 1 μM, 5 μM	60 minutes	To evaluate the effect of BAY-876 on basal and overload-stimulated muscle glucose uptake. Results showed that low-dose BAY-876 (0.05 μM) completely impaired overload-stimulated glucose uptake but did not affect basal uptake.	PMC9776291
Mice	Muscle-specific GLUT1 knockout (mGLUT1KO) mice	Ex vivo muscle incubation	0.05 μM, 1 μM, 5 μM	60 minutes	To assess the effect of BAY-876 on basal and overload-stimulated muscle glucose uptake. Results showed that a low dose of BAY-876 (0.05 μM) completely impaired overload-stimulated but not basal glucose uptake.	PMC9776291
C57BL/6 mice	STZ-induced hyperglycemic model	Intravenous injection	1.0 mg/kg	Daily injections for 16 days	BAY-876 significantly reduced STZ-induced astrocyte proliferation but had no effect on microglia numbers	PMC11131277
Balb/c mice	4T1 breast tumor xenograft model	Tail vein injection	10 mg/kg	Single dose, monitored for 14 days	Evaluate the in vivo antitumor efficacy and biodistribution of CFMB, showing significant tumor growth suppression without systemic toxicity.	PMC11187878
Mice	NCI-H226 xenograft tumors	Intraperitoneal injection	100 mg/kg	Every two days	Evaluate the therapeutic effect of GLUT inhibitors on SLC7A11-high tumors, results showed BAY-876 significantly suppressed tumor growth	PMC7194135
Mice	PDX model	Oral	2 mg/kg daily	Once daily for 30 days	Impaired tumor growth with no significant loss of body weight	PMC7442809
C57BL/6J mice	Subcutaneous GBM model	Subcutaneous injection	2 nM	21 days	Inhibit lactate excretion and delay tumor growth	PMC11095231
Nude mice	HCC xenograft model	Gavage	2.5 mg/kg	Every 3 days for 28 days	BAY-876 significantly inhibited BMP4-induced subcutaneous tumor growth and glycogen accumulation	PMC10339511
RAG1−/−γc− mice	LS174T cell xenograft model	Oral administration	3 mg/kg/day	Once daily for 12 days	BAY-876 significantly inhibited tumor growth in the LS174T cell xenograft model.	PMC11010912
SCID mice	LS174T xenograft model	Oral (BAY-876), Intraperitoneal (DBI-1)	3 mg/kg/day (BAY-876), 40 mg/kg/day (DBI-1)	Once daily for 12 days	BAY-876 and DBI-1 alone or in combination inhibited tumor growth, with combination therapy being more effective than either compound alone.	PMC9081236

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CAS No.: 1799753-84-6

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CAS No.: 1799753-84-6

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed