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Chemical Structure| 1807523-99-4 Chemical Structure| 1807523-99-4

Structure of IACS-010759 HCl
CAS No.: 1807523-99-4

Chemical Structure| 1807523-99-4

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IACS-010759 or IACS-10759 is a potent inhibitor of complex I of OXPHOS. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NAD+ in immunoprecipitated complex I in low nM range. IACS-10759 is orally bioavailable with excellent physicochemical properties in preclinical species, and shows significant efficacy in multiple tumor indications both in vitro and in vivo. IACS-10759 causes robust tumor regression, but has no effect in the same model when glycolysis is restored.

Synonyms: IACS-10759 hydrochloride; IACS-010759 hydrochloride

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Product Details of IACS-010759 HCl

CAS No. :1807523-99-4
Formula : C25H26ClF3N6O4S
M.W : 599.03
SMILES Code : FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC(N5CCC(S(=O)(C)=O)CC5)=CC=C4)C(C)=N3)=N2)C=C1.[H]Cl
Synonyms :
IACS-10759 hydrochloride; IACS-010759 hydrochloride
MDL No. :N/A

Safety of IACS-010759 HCl

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1 mM

5 mM

10 mM

1.67mL

0.33mL

0.17mL

8.35mL

1.67mL

0.83mL

16.69mL

3.34mL

1.67mL

 

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