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With triphenylphosphine In 1,4-dioxane at 80℃; for 1h;
(b) Synthesis of 4-((5-Phenyloxazol-2-yl)amino)phenol (3)
General procedure: The resulting compound 2-azido-1-phenylethan-1-one (0.31 g,1.91 mmol) was dissolved in 10 mL of 1,4-dioxane. The triphenylphosphine (0.55 g, 2.09 mmol) and 4-hydroxy phenylisothiocyanate (0.26 g, 1.74 mmol) were added at room temperature,and the mixture was refluxed at 80 °C for 1 h. After the reaction was completed, the reaction mixture was diluted with 10 mL of ethyl acetate, washed with water, dried over anhydrous magnesium sulfate, and concentrated under a reduced pressure. The residues were purified using silica gel column chromatography (hexane : ethyl acetate=2 : 1) to obtain thefinal product 3 (0.25 g, 56%).
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