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[ CAS No. 1807861-48-8 ] {[proInfo.proName]}

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Chemical Structure| 1807861-48-8
Chemical Structure| 1807861-48-8
Structure of 1807861-48-8 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1807861-48-8 ]

CAS No. :1807861-48-8 MDL No. :MFCD31619281
Formula : C24H23F3N4O Boiling Point : -
Linear Structure Formula :- InChI Key :DFULPGUTXZTYKA-UHFFFAOYSA-N
M.W : 440.46 Pubchem ID :124085867
Synonyms :

Safety of [ 1807861-48-8 ]

Signal Word:Danger Class:9
Precautionary Statements:P201-P264-P280-P301+P330+P331-P312 UN#:3077
Hazard Statements:H302-H361-H372-H410 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1807861-48-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1807861-48-8 ]

[ 1807861-48-8 ] Synthesis Path-Downstream   1~4

YieldReaction ConditionsOperation in experiment
18% With sodium methylate In methanol for 15h; Reflux; 2 Synthesis of 1 General procedure: To a 10 mL three necked flask, was charged with compound IF (0.4 mmd), compound 1B (0.4 mmd), methand (3mL) and MeONa (1.2 mmd). The mixture was refiuxed for I 5h hours. Analysis of the reaction mixture by LC-MS confirmed that thereaction was complete. The reaction was cooled down to room temperature. Half of the solvent was removed under vacuum. Water (2 mL) was added drop wise. A brown solid precipitated, was filtered and washed with water. The solid was dried under vacuum to afford compound I (yield 25%).
  • 2
  • [ 793-19-1 ]
  • [ 1710603-20-5 ]
  • [ 1807861-48-8 ]
YieldReaction ConditionsOperation in experiment
Stage #1: bis(2-methoxycarbonylethyl)benzylamine With sodium hydride In tetrahydrofuran at 0℃; Inert atmosphere; Reflux; Stage #2: C11H12F3N3 In methanol for 12h; Reflux; Inert atmosphere; 3.1.3. General Procedure for the Synthesis of Impiridones Type 7 General procedure: To the amine component R1-NH2 (3 mmol), dissolved in MeOH, methylacrylate (0.68 mL,7.5 mmol) was added and the mixture was stirred for 24 h at room temperature, concentrated invacuo and the obtained crude amine (3a,d-h) was dissolved in anhydrous THF (12 mL). Under Aratmosphere NaH (0.36 g, 15 mmol) was added in small portions to the intensively stirred solutionthat previously was cooled down to 0 °C. The resulting suspension was stirred for additional 2 h atreflux temperature and concentrated to dryness under vacuum. The resulting solid residue containingthe crude sodium salt of methoxycarbonylpiperidone (type 4) was dissolved in anhydrous MeOH(15 mL). To this solution was added 2-(R2-NH)-substituted 3,4-dihydroimidazole of type 6 (3 mmol)prepared in separate steps as described above (Section 3.1.1 and 3.1.2). The basic solution was stirredat a reflux for 12 h, under Ar atmosphere then concentrated to dryness, and the solid residue wasdissolved in dichloromethane (DCM, 60 mL). The solution was washed with brine (30 mL), dried overNa2SO4, filtered, and concentrated in vacuum. The solid/oily residue was subjected to subsequentflash column chromatography (over silica using DCM:MeOH 10:1 as eluent) and recrystallisation frommethanol. The yields of the pure products type 7 presented on Scheme 1 were calculated from theinitial amount (3 mmol) of the precursor amine R1-NH2.
  • 3
  • [ 100-46-9 ]
  • [ 1807861-48-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: methanol / 24 h / 25 °C 2.1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux 2.2: 12 h / Reflux; Inert atmosphere
  • 4
  • [ 1710603-20-5 ]
  • [ 3939-01-3 ]
  • [ 1807861-48-8 ]
YieldReaction ConditionsOperation in experiment
85 % With sodium methylate In methanol at 80℃; 3 Application example 3 Add 10g (41.3mmol) N-(4-trifluoromethylbenzyl)-4,5-dihydro-1-hydrogen-imidazole-2-ammonia 18-3, 100mL methanol, 4.46g ( 82.6mmol) sodium methoxide, then added 10.7g (37.6mmol) 1-benzyl-3-methoxycarbonyl-4-piperidone hydrochloride, and reacted at 80°C for 20 hours.After the reaction, the methanol was distilled off under reduced pressure, and then the remaining solid was extracted with dichloromethane and water. After the organic phase was distilled and dried under reduced pressure, 15.5 g of light yellow solid product ONC 212 was obtained, with a yield of 85% and a purity of >99%.
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