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Chemical Structure| 1831144-46-7 Chemical Structure| 1831144-46-7

Structure of iJak-381
CAS No.: 1831144-46-7

Chemical Structure| 1831144-46-7

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iJak-381 is a JAK1/2 inhibitor with anti-inflammatory activity. iJak-381 blocks IL-13 signaling and also inhibits IL-4 and IL-6 signaling pathways. iJak-381 also reduced p-STAT6 levels and inhibited the influx of inflammatory cells into the lungs of mice. iJak-381 inhibits airway hyperresponsiveness (AHR)

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Product Details of iJak-381

CAS No. :1831144-46-7
Formula : C28H28ClF2N9O3
M.W : 612.03
SMILES Code : O=C(C1=C2N=CC=CN2N=C1)NC3=CN(CC(N4CCC(N(CCC#N)C)CC4)=O)N=C3C5=CC(Cl)=CC=C5OC(F)F
MDL No. :N/A
InChI Key :ITNFPSJJBYFVEA-UHFFFAOYSA-N
Pubchem ID :118522534

Safety of iJak-381

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of iJak-381

epigenetics
RTK
JAK-STAT

Isoform Comparison

Biological Activity

Description
iJak-381 acts as an inhibitor of JAK1/2, exhibiting anti-inflammatory properties. It disrupts IL-13 signaling and also impedes the signaling pathways of IL-4 and IL-6. Additionally, iJak-381 lowers p-STAT6 levels and curtails the entry of inflammatory cells into the mouse lungs. It effectively prevents airway hyperresponsiveness (AHR)[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.63mL

0.33mL

0.16mL

8.17mL

1.63mL

0.82mL

16.34mL

3.27mL

1.63mL

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