Home Cart 0 Sign in  

[ CAS No. 184368-74-9 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 184368-74-9
Chemical Structure| 184368-74-9
Structure of 184368-74-9 * Storage: {[proInfo.prStorage]}

Quality Control of [ 184368-74-9 ]

Related Doc. of [ 184368-74-9 ]

SDS
Alternatived Products of [ 184368-74-9 ]
Alternatived Products of [ 184368-74-9 ]

Product Details of [ 184368-74-9 ]

CAS No. :184368-74-9 MDL No. :MFCD23704701
Formula : C12H19NO4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :241.28 g/mol Pubchem ID :11806782
Synonyms :

Safety of [ 184368-74-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 184368-74-9 ]

  • Upstream synthesis route of [ 184368-74-9 ]
  • Downstream synthetic route of [ 184368-74-9 ]

[ 184368-74-9 ] Synthesis Path-Upstream   1~8

  • 1
  • [ 24424-99-5 ]
  • [ 184368-74-9 ]
YieldReaction ConditionsOperation in experiment
27% With triethylamine In dichloromethane at 20℃; for 15 h; The compound 48-d (0.33 g, 2.36 mmol) was dissolved in methylene chloride (15 mL), di-tert-butyl dicarbonate (0.76 g, 3.49 mmol) and triethylamine (0.6 mL, And the mixture was stirred at room temperature for 15 hours. 2N HCl aqueous solution (2 mL) was added to the reaction mixture, stirred for 10 minutes, and further distilled water (20 mL) was added thereto, followed by extraction with methylene chloride. The organic layer was washed with distilled water and saturated brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by silica gel column chromatography (ethyl acetate: n-hexane = 1: 9) to give the title compound 49-a (0.15 g, 27percent) as a colorless liquid.
Reference: [1] Patent: KR101798840, 2017, B1, . Location in patent: Paragraph 0984-0987
  • 2
  • [ 67-56-1 ]
  • [ 201230-82-2 ]
  • [ 138647-49-1 ]
  • [ 184368-74-9 ]
YieldReaction ConditionsOperation in experiment
2 g With palladium diacetate; triethylamine; triphenylphosphine In N,N-dimethyl-formamide at 20℃; for 12 h; To a mixture of tert-butyl4-(((trifluoromethyl)sulfonyl)oxy)-3 ,6-dihydropyridine-1(2H)-carboxylate (5.6 g, 16.8 mmol), Et3N (4.7 ml, 33.0 mmol) in DMF (69 ml) andMeOH (52 ml) was added PPh3 (0.2 g, 1.0 mmol) and Pd(OAc)2 (0.1 g, 0.5 mmol) at RT under nitrogen followed by stirring under CO atmosphere for 12 h. The reaction mixture was concentrated under reduced pressure. The crude residue was purified by column chromatography to give 2.0 g of the title compound as a greenish liquid. 1H-NMR (400MHz; DMSO-d6): ö 6.85 (d, 1H), 4.00 (t, 2H), 3.67 (s, 3H), 3.42 (d, 2H), 2.25 (t, 2H),1.41 (s, 9H).
Reference: [1] Journal of Medicinal Chemistry, 2006, vol. 49, # 15, p. 4544 - 4567
[2] Heterocycles, 1996, vol. 43, # 10, p. 2131 - 2138
[3] Patent: WO2018/115591, 2018, A1, . Location in patent: Page/Page column 84; 85
  • 3
  • [ 138647-49-1 ]
  • [ 184368-74-9 ]
YieldReaction ConditionsOperation in experiment
65% With triethylamine; triphenylphosphine In methanol; hexane; N,N-dimethyl-formamide B.
Methyl 1-boc-1,2,3,6-Tetrahydro-4-pyridinecarboxylate
To a stirred solution of 1-Boc-1,2,3,6-tetrahydro-4-[(trifluoromethyl)sulfonyloxy]pyridine (74.84 g, 226 mmol) in N,N-dimethylformamide (60 mL) was added triethylamine (4.2 mL, 30.2 mmol), palladium acetate (0.100 g, 0.45 mmol), triphenylphosphine (0. 235 g, 0.9 mmol), and methanol (24.5 mL) and the solution was placed under an atmosphere of carbon monoxide.
After stirring for 48 h, the solvent was removed in vacuo.
The residue was chromatographed over silica gel, eluding with 5-10percent ethyl acetate in hexane.
The product containing fractions were combined and concentrated in vacuo to give 2.35 g (65percent) of the title compound as a clear oil.
1H-NMR;
FD-MS, m/e 240.2 (m); Analysis for C12H19NO4: Calcd: C, 59.74; H, 7.94; N, 5.81; Found: C, 59.60; H, 8.07; N, 5.85.
Reference: [1] Patent: US6635657, 2003, B1,
  • 4
  • [ 50893-53-3 ]
  • [ 24424-99-5 ]
  • [ 80845-58-5 ]
  • [ 184368-74-9 ]
Reference: [1] Patent: US6518423, 2003, B1,
  • 5
  • [ 79099-07-3 ]
  • [ 184368-74-9 ]
Reference: [1] Journal of Medicinal Chemistry, 2006, vol. 49, # 15, p. 4544 - 4567
[2] Heterocycles, 1996, vol. 43, # 10, p. 2131 - 2138
[3] Patent: WO2018/115591, 2018, A1,
  • 6
  • [ 2459-09-8 ]
  • [ 184368-74-9 ]
Reference: [1] Patent: KR101798840, 2017, B1,
  • 7
  • [ 94983-57-0 ]
  • [ 184368-74-9 ]
Reference: [1] Patent: KR101798840, 2017, B1,
  • 8
  • [ 80845-58-5 ]
  • [ 184368-74-9 ]
Reference: [1] Patent: KR101798840, 2017, B1,
Historical Records

Related Functional Groups of
[ 184368-74-9 ]

Esters

Chemical Structure| 912444-89-4

[ 912444-89-4 ]

1-tert-Butyl 4-ethyl 2,3,6,7-tetrahydro-1H-azepine-1,4-dicarboxylate

Similarity: 0.93

Chemical Structure| 206111-40-2

[ 206111-40-2 ]

1-tert-Butyl 4-ethyl 3-hydroxy-5,6-dihydropyridine-1,4(2H)-dicarboxylate

Similarity: 0.86

Chemical Structure| 135716-08-4

[ 135716-08-4 ]

tert-Butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate

Similarity: 0.81

Chemical Structure| 180863-55-2

[ 180863-55-2 ]

Methyl 3-(((tert-butoxycarbonyl)amino)methyl)benzoate

Similarity: 0.79

Chemical Structure| 80221-26-7

[ 80221-26-7 ]

Ethyl N-Cbz-4-piperidineacetate

Similarity: 0.77

Amides

Chemical Structure| 912444-89-4

[ 912444-89-4 ]

1-tert-Butyl 4-ethyl 2,3,6,7-tetrahydro-1H-azepine-1,4-dicarboxylate

Similarity: 0.93

Chemical Structure| 206111-40-2

[ 206111-40-2 ]

1-tert-Butyl 4-ethyl 3-hydroxy-5,6-dihydropyridine-1,4(2H)-dicarboxylate

Similarity: 0.86

Chemical Structure| 86447-11-2

[ 86447-11-2 ]

1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylic acid

Similarity: 0.86

Chemical Structure| 170097-67-3

[ 170097-67-3 ]

2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

Similarity: 0.85

Chemical Structure| 149353-95-7

[ 149353-95-7 ]

2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid

Similarity: 0.85

Related Parent Nucleus of
[ 184368-74-9 ]

Pyridines

Chemical Structure| 206111-40-2

[ 206111-40-2 ]

1-tert-Butyl 4-ethyl 3-hydroxy-5,6-dihydropyridine-1,4(2H)-dicarboxylate

Similarity: 0.86

Chemical Structure| 86447-11-2

[ 86447-11-2 ]

1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylic acid

Similarity: 0.86

Chemical Structure| 66207-23-6

[ 66207-23-6 ]

Benzyl 5,6-dihydropyridine-1(2H)-carboxylate

Similarity: 0.74

Chemical Structure| 128372-89-4

[ 128372-89-4 ]

tert-Butyl 2-oxo-5,6-dihydropyridine-1(2H)-carboxylate

Similarity: 0.72

Chemical Structure| 85838-94-4

[ 85838-94-4 ]

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate

Similarity: 0.72