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[ CAS No. 1857-19-8 ] {[proInfo.proName]}

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Chemical Structure| 1857-19-8
Chemical Structure| 1857-19-8
Structure of 1857-19-8 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1857-19-8 ]

CAS No. :1857-19-8 MDL No. :MFCD06655264
Formula : C4H10N2O Boiling Point : -
Linear Structure Formula :- InChI Key :KNVRBEGQERGQRP-UHFFFAOYSA-N
M.W : 102.14 Pubchem ID :4961823
Synonyms :

Safety of [ 1857-19-8 ]

Signal Word:Danger Class:8
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338+P310-P332+P313-P362-P403+P233-P405-P501 UN#:2735
Hazard Statements:H314 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1857-19-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1857-19-8 ]
  • Downstream synthetic route of [ 1857-19-8 ]

[ 1857-19-8 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 167303-60-8 ]
  • [ 1857-19-8 ]
YieldReaction ConditionsOperation in experiment
94% With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 3 h; General procedure: This procedure is illustrated for compound 11a. To a solution of compound 10a (170 mg, 0.77 mmol) in methanol (10 mL), 10percent Pd/C was added. The reaction was hydrogenated at room temperature and atmospheric pressure for 3 h. Then the catalyst was filtered off through Celite, and the clear solution, taken to dryness, afforded the title compound as an oil. The reaction was monitored by TLC and, for stability problems, the amine was directly used in the subsequent reaction. Yield 97percent.
Reference: [1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 3, p. 1285 - 1297
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 16, p. 2715 - 2718
[3] Chemical Communications, 2016, vol. 52, # 43, p. 7043 - 7046
  • 2
  • [ 1138-80-3 ]
  • [ 68-12-2 ]
  • [ 1857-19-8 ]
Reference: [1] European Journal of Organic Chemistry, 2018, vol. 2018, # 15, p. 1765 - 1773
  • 3
  • [ 2185-00-4 ]
  • [ 124-40-3 ]
  • [ 1857-19-8 ]
Reference: [1] Journal of the Chemical Society, 1950, p. 3009,3011
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