Home Cart 0 Sign in  

[ CAS No. 186593-26-0 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 186593-26-0
Chemical Structure| 186593-26-0
Structure of 186593-26-0 *Storage: {[proInfo.prStorage]}

Quality Control of [ 186593-26-0 ]

Related Doc. of [ 186593-26-0 ]

SDS
Alternatived Products of [ 186593-26-0 ]
Alternatived Products of [ 186593-26-0 ]

Product Details of [ 186593-26-0 ]

CAS No. :186593-26-0MDL No. :MFCD04114224
Formula : C5H4N2O3 Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :140.10Pubchem ID :2762905
Synonyms :

Computed Properties of [ 186593-26-0 ]

TPSA : 78.9 H-Bond Acceptor Count : 4
XLogP3 : 0.3 H-Bond Donor Count : 1
SP3 : 0.00 Rotatable Bond Count : 0

Safety of [ 186593-26-0 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 186593-26-0 ]

  • Upstream synthesis route of [ 186593-26-0 ]
  • Downstream synthetic route of [ 186593-26-0 ]

[ 186593-26-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 3543-01-9 ]
  • [ 186593-26-0 ]
YieldReaction ConditionsOperation in experiment
47% With dipotassium peroxodisulfate In concd sulfuric acid 132d.
3-hydroxy-5-nitropyridine
Potassium persulfate (56.8 g 210 mmol) was ground into 31.5 mL of concd sulfuric acid, and the solution was added to a solution of the product of Example 132c (2.75 g 25 mmol) in concd sulfuric acid (27 mL).
The mixture was allowed to stand for 72 hours, then was poured over ice and adjusted to pH 6 with concd NH4 OH.
The solution was extracted with EtOAc (4*100 mL), then the EtOAc extracts were dried (MgSO4) and concentrated.
The crude product was chromatographed (silica gel; CHCl3 /MeOH, 99:1 to 9:1) to afford 1.65 g (47percent) of the title compound. 1 H NMR (CDCl3, 300 MHz) δ 8.81(d, J=3 Hz, 1H), 8.51 (d, H=3 Hz, 1H), 7.82 (dd, J=2.5 Hz, 1H). MS (DCI/NH3) m/z 141 (M+H)+, 158 (M+NH4)+.
Reference: [1] Patent: US6133253, 2000, A,
Historical Records

Related Functional Groups of
[ 186593-26-0 ]

Nitroes

Chemical Structure| 908248-27-1

[ 908248-27-1 ]

2-Amino-5-nitropyridin-3-ol

Similarity: 0.86

Chemical Structure| 36625-57-7

[ 36625-57-7 ]

(5-Nitropyridin-2-yl)methanol

Similarity: 0.80

Chemical Structure| 13505-06-1

[ 13505-06-1 ]

4-Nitropyridin-3-ol

Similarity: 0.78

Chemical Structure| 75711-00-1

[ 75711-00-1 ]

2-Chloro-3-methoxy-5-nitropyridine

Similarity: 0.77

Chemical Structure| 21203-68-9

[ 21203-68-9 ]

2-Methyl-5-nitropyridine

Similarity: 0.75

Alcohols

Chemical Structure| 908248-27-1

[ 908248-27-1 ]

2-Amino-5-nitropyridin-3-ol

Similarity: 0.86

Chemical Structure| 36625-57-7

[ 36625-57-7 ]

(5-Nitropyridin-2-yl)methanol

Similarity: 0.80

Chemical Structure| 13505-06-1

[ 13505-06-1 ]

4-Nitropyridin-3-ol

Similarity: 0.78

Chemical Structure| 98197-88-7

[ 98197-88-7 ]

2-(Hydroxymethyl)-4-nitropyridine

Similarity: 0.68

Chemical Structure| 5437-99-0

[ 5437-99-0 ]

8-Nitroquinolin-6-ol

Similarity: 0.68

Related Parent Nucleus of
[ 186593-26-0 ]

Pyridines

Chemical Structure| 908248-27-1

[ 908248-27-1 ]

2-Amino-5-nitropyridin-3-ol

Similarity: 0.86

Chemical Structure| 36625-57-7

[ 36625-57-7 ]

(5-Nitropyridin-2-yl)methanol

Similarity: 0.80

Chemical Structure| 13505-06-1

[ 13505-06-1 ]

4-Nitropyridin-3-ol

Similarity: 0.78

Chemical Structure| 75711-00-1

[ 75711-00-1 ]

2-Chloro-3-methoxy-5-nitropyridine

Similarity: 0.77

Chemical Structure| 21203-68-9

[ 21203-68-9 ]

2-Methyl-5-nitropyridine

Similarity: 0.75