Alternatived Products of [ 187035-81-0 ]
Product Details of [ 187035-81-0 ]
CAS No. : | 187035-81-0 |
MDL No. : | MFCD07367356 |
Formula : |
C8H7F3N2O2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
220.15
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 187035-81-0 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 187035-81-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 187035-81-0 ]
- 1
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[ 187035-81-0 ]
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[ 35613-84-4 ]
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[ 218276-60-9 ]
Yield | Reaction Conditions | Operation in experiment |
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With sodium ethanolate; In ethanol; |
3-Isopropyl-5-(4-trifluoromethyl-5-pyrimidyl)-1,2,4-oxadiazole (Table 1, No. 189) 2 g of ethyl 4-trifluoromethylpyrimidine-5-carboxylate and 1.56 g of <strong>[35613-84-4]isobutyramide oxime</strong> were initially charged in 15 ml of ethanol and cooled to 0 C. 10 ml of a 1.2 molar sodium ethoxide solution were added dropwise to this solution. The mixture was allowed to warm to room temperature over a period of one hour and then heated under reflux until the reaction, according to TLC, had ended. The reaction mixture was concentrated and the residue was taken up in saturated ammonium chloride solution and extracted with diethyl ether. Chromatographic purification of the crude product gave the desired compound as a yellowish oil. 1H-NMR (CDCl3, 300 MHz): d=1.43 (d, J=7 Hz, 6H), 3.22 (hept., J=7 Hz, 1H), 9.52 (s, 1H), 9.58 (s, 1H) ppm. |