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[ CAS No. 18797-86-9 ]

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Chemical Structure| 18797-86-9
Chemical Structure| 18797-86-9
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Product Details of [ 18797-86-9 ]

CAS No. :18797-86-9 MDL No. :MFCD00050910
Formula : C22H26N2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :366.45 g/mol Pubchem ID :-
Synonyms :

Safety of [ 18797-86-9 ]

Signal Word:Warning Class:
Precautionary Statements:P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501 UN#:
Hazard Statements:H302-H315-H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 18797-86-9 ]

  • Downstream synthetic route of [ 18797-86-9 ]

[ 18797-86-9 ] Synthesis Path-Downstream   1~11

  • 1
  • [ 18797-86-9 ]
  • [ 130-95-0 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; KH2PO4 buffer In acetonitrile at 65℃;
  • 2
  • [ 18797-86-9 ]
  • C20H23(2)HN2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With d(4)-methanol at 21 - 22℃;
  • 3
  • [ 18797-86-9 ]
  • C22H26FN2O3(1+)*BF4(1-) [ No CAS ]
YieldReaction ConditionsOperation in experiment
96% With Selectfluor In acetonitrile
  • 5
  • [ 18797-86-9 ]
  • Acetic acid (R)-((2S,4S,5R)-5-acetyl-1-aza-bicyclo[2.2.2]oct-2-yl)-(6-methoxy-quinolin-4-yl)-methyl ester [ No CAS ]
  • Acetic acid (R)-((2S,4S,5S)-5-acetyl-1-aza-bicyclo[2.2.2]oct-2-yl)-(6-methoxy-quinolin-4-yl)-methyl ester [ No CAS ]
  • Acetic acid (R)-[(2S,4S,5R)-5-(1-fluoro-ethyl)-5-hydroxy-1-aza-bicyclo[2.2.2]oct-2-yl]-(6-methoxy-quinolin-4-yl)-methyl ester [ No CAS ]
  • Acetic acid (R)-[(2S,4S,5S)-5-(1-fluoro-ethyl)-5-hydroxy-1-aza-bicyclo[2.2.2]oct-2-yl]-(6-methoxy-quinolin-4-yl)-methyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
1: 20% 2: 20% 3: 20% 4: 10% With hydrogen fluoride; dihydrogen peroxide; antimony pentafluoride at -35℃; for 0.05h;
  • 6
  • BF4(1-)*C41H45F6N4O3(1+) [ No CAS ]
  • [ 18797-86-9 ]
  • bis[p-(methyl(2,2,2-trifluoroethyl)amino)]benzhydrylium tetrafluoroborate [ No CAS ]
YieldReaction ConditionsOperation in experiment
In dichloromethane at 20℃;
  • 7
  • [ 1372721-77-1 ]
  • [ 18797-86-9 ]
  • [ 1185875-38-0 ]
YieldReaction ConditionsOperation in experiment
In [D3]acetonitrile
  • 8
  • [ 18797-86-9 ]
  • bis[p-(methyl(2,2,2-trifluoroethyl)amino)]benzhydrylium tetrafluoroborate [ No CAS ]
  • BF4(1-)*C41H45F6N4O3(1+) [ No CAS ]
YieldReaction ConditionsOperation in experiment
In dichloromethane at 20℃;
  • 9
  • [ 18797-86-9 ]
  • [ 914079-51-9 ]
YieldReaction ConditionsOperation in experiment
58% Stage #1: (R)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl acetate With boron tribromide In dichloromethane at -78℃; Inert atmosphere; Stage #2: With ammonia; water In dichloromethane at 0 - 20℃; Inert atmosphere; 2.4 (R)-(6-Hydroxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl acetate Q-526 Q-5 was prepared from O-acetylquinine27 according to the literature procedure and similar to QD-2, white solid, 58% yield. 1H NMR (400 MHz, CDCl3): δ 8.67 (d, J = 4.5 Hz, 1H), 7.97 (d, J = 9.2 Hz, 1H), 7.55 (d, J = 2.6 Hz, 1H), 7.34-7.25 (m, 2H), 6.57 (d, J = 5.7 Hz, 1H), 6.05-5.96 (m, 2H), 5.13-5.08 (m, 2H), 3.34-3.26 (m, 1H), 3.05-2.91 (m, 2H), 2.83-2.69 (m, 2H), 2.32-2.26 (m, 1H), 2.12 (s, 3H), 1.98-1.85 (m, 1H), 1.82 (s, 1H), 1.57-1.45 (m, 2H), 1.40-1.32 (m, 1H).
  • 10
  • [ 18797-86-9 ]
  • (1R)-((2S,4S,5R)-5-(1,2-difluoroethyl)quinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% With 4-tolyl iodide; Olah′s reagent; Selectfluor In 1,2-dichloro-ethane at 20℃; for 14h; Sealed tube;
  • 11
  • [ 108-24-7 ]
  • [ 130-95-0 ]
  • [ 18797-86-9 ]
YieldReaction ConditionsOperation in experiment
88% With pyridine at 0 - 20℃; for 21h; Inert atmosphere;
Historical Records

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[ 18797-86-9 ]

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Related Parent Nucleus of
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Quinolines

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Quinuclidines

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