Home Cart Sign in  
Chemical Structure| 1884222-74-5 Chemical Structure| 1884222-74-5

Structure of SBP-7455
CAS No.: 1884222-74-5

Chemical Structure| 1884222-74-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

SBP-7455 is an autophagy inhibitor targeting ULK1/ULK2, holding significant application prospects in research on triple-negative breast cancer and other cancers.

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of SBP-7455

CAS No. :1884222-74-5
Formula : C16H17F3N4O2
M.W : 354.33
SMILES Code : FC(C1=CN=C(NC2=CC=C(OC)C(OC)=C2)N=C1NC3CC3)(F)F
MDL No. :N/A
InChI Key :BQROJYIEHOOQBY-UHFFFAOYSA-N
Pubchem ID :132178569

Safety of SBP-7455

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of SBP-7455

Hedgehog

Isoform Comparison

Biological Activity

Description
SBP-7455 is a potent, orally active dual inhibitor of ULK1/ULK2 autophagy, exhibiting IC50 values of 13 nM and 476 nM in ADP-Glo assays, respectively. SBP-7455 effectively inhibits ULK1/2 enzymatic activity and holds promise for triple-negative breast cancer (TNBC) research [1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.82mL

0.56mL

0.28mL

14.11mL

2.82mL

1.41mL

28.22mL

5.64mL

2.82mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

Categories