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[ CAS No. 19017-52-8 ]

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Chemical Structure| 19017-52-8
Chemical Structure| 19017-52-8
Structure of 19017-52-8 * Storage: {[proInfo.prStorage]}

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Product Details of [ 19017-52-8 ]

CAS No. :19017-52-8 MDL No. :MFCD00152035
Formula : C11H10ClNO2 Boiling Point : 448.4°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :223.66 g/mol Pubchem ID :-
Synonyms :

Safety of [ 19017-52-8 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 19017-52-8 ]

  • Downstream synthetic route of [ 19017-52-8 ]

[ 19017-52-8 ] Synthesis Path-Downstream   1~15

  • 1
  • 4-(4-chloro-phenylhydrazono)-valeric acid ethyl ester [ No CAS ]
  • [ 19017-52-8 ]
YieldReaction ConditionsOperation in experiment
With zinc(II) chloride Erwaermen des Reaktionsprodukts mit methanol. KOH;
  • 2
  • [ 64-17-5 ]
  • [ 19017-52-8 ]
  • [ 3446-72-8 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid for 1h; Heating; Yield given;
  • 3
  • [ 57335-86-1 ]
  • [ 33577-16-1 ]
  • [ 19017-52-8 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; N-benzyl-trimethylammonium hydroxide 1.) THF, reflux, 10 h, 2.) ethanol, room temp., 1 h; Multistep reaction;
  • 4
  • [ 504-24-5 ]
  • [ 19017-52-8 ]
  • 2-(5-chloro-2-methyl-1<i>H</i>-indol-3-yl)-<i>N</i>-pyridin-4-yl-acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
63% With 2-chloro-1-methylpyrimidinium iodide; triethylamine In dichloromethane for 2h; Heating;
YieldReaction ConditionsOperation in experiment
64% R.84 2-(5-chloro-2-methyl-1H-indol-3-yl)acetic acid Reference Example 84 2-(5-chloro-2-methyl-1H-indol-3-yl)acetic acid Reaction was conducted in the same manner as Reference Example 81, except that 4-chlorophenylhydrazine hydrochloride was used instead of 4-trifluoromethoxyphenylhydrazine hydrochloride, to obtain the title compound (64% yield). The NMR data for the obtained compound were as follows. NMR: (300 MHz, DMSO-d6) δ: 2.31 (3H,s), 3.55 (2H,s), 6.98 (1H,dd), 7.26 (1H,d), 7.39 (1H,d), 11.05 (1H,s), 11.8-12.2 (1H,m)
4-(2-Methyl-1,3-dioxolanyl-2)-6-chlor-2-oxo-1,2,3,4-Tetrahydro-chinolin. konz. HCl, (Siedetemp., 15min);
(5-Chlor-2-methyl-1-acetyl-indolyl-3)-essigsaeure-ethylester (IV), NaOH, sd. wss. Me.;
  • 7
  • [ 1073-70-7 ]
  • [ 19017-52-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 1.) CH3COONa, 1 M CH3COOH, 2.) H2SO4 / 2.) EtOH, reflux, 3 h 2: 6 M NaOH / ethanol / 1 h / Heating
Multi-step reaction with 2 steps 1.1: sodium acetate / acetic acid / 70 °C 1.2: Reflux 2.1: sodium hydroxide; water / ethanol / 3 h / 20 °C
  • 8
  • [ 539-88-8 ]
  • [ 19017-52-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 1.) CH3COONa, 1 M CH3COOH, 2.) H2SO4 / 2.) EtOH, reflux, 3 h 2: 6 M NaOH / ethanol / 1 h / Heating
Multi-step reaction with 2 steps 2: ZnCl2 / Erwaermen des Reaktionsprodukts mit methanol. KOH
Multi-step reaction with 2 steps 1.1: sodium acetate / acetic acid / 70 °C 1.2: Reflux 2.1: sodium hydroxide; water / ethanol / 3 h / 20 °C
  • 9
  • [ 19017-52-8 ]
  • [ 117752-78-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: conc.H2SO4 / 1 h / Heating 2: LiAlH4 / tetrahydrofuran / 2 h / Heating
  • 10
  • [ 19017-52-8 ]
  • 5-Chloro-3-(2-chloro-ethyl)-2-methyl-1H-indole [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: conc.H2SO4 / 1 h / Heating 2: LiAlH4 / tetrahydrofuran / 2 h / Heating 3: SOCl2
  • 11
  • [ 19017-52-8 ]
  • 3-[2-(4-Benzyl-piperazin-1-yl)-ethyl]-5-chloro-2-methyl-1H-indole [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: conc.H2SO4 / 1 h / Heating 2: LiAlH4 / tetrahydrofuran / 2 h / Heating 3: SOCl2 4: triethylamine / benzene
  • 12
  • [ 1075-35-0 ]
  • [ 19017-52-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 1.2: 20 °C 2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 1.2: -78 - 20 °C / Inert atmosphere 1.3: 24 h / 20 °C / Inert atmosphere 2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 1.2: Inert atmosphere 1.3: 19 h / 20 °C 2.1: lithium hydroxide / 1,4-dioxane; water / 1.5 h
  • 13
  • [ 19017-52-8 ]
  • [ 1297276-86-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: sodium acetate / toluene / 16 h / 200 °C / Inert atmosphere 2: hydrazine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 85 °C 4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C
Multi-step reaction with 5 steps 1: sodium acetate / 16 h / 200 °C / Inert atmosphere; Sonication 2: hydrazine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 85 °C / Inert atmosphere 4: potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere; Heating 5: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C
  • 14
  • [ 19017-52-8 ]
  • [ 1297284-48-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium acetate / toluene / 16 h / 200 °C / Inert atmosphere 2: hydrazine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux
Multi-step reaction with 2 steps 1: sodium acetate / 16 h / 200 °C / Inert atmosphere; Sonication 2: hydrazine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux
  • 15
  • [ 19017-52-8 ]
  • [ 1297284-49-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: sodium acetate / toluene / 16 h / 200 °C / Inert atmosphere 2: hydrazine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 85 °C
Multi-step reaction with 3 steps 1: sodium acetate / 16 h / 200 °C / Inert atmosphere; Sonication 2: hydrazine / isopropyl alcohol / 16 h / Inert atmosphere; Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 85 °C / Inert atmosphere
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