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[ CAS No. 19178-21-3 ]

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2D
Chemical Structure| 19178-21-3
Chemical Structure| 19178-21-3
Structure of 19178-21-3 *Storage: {[proInfo.prStorage]}

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Product Details of [ 19178-21-3 ]

CAS No. :19178-21-3MDL No. :MFCD16872923
Formula : C9H12N2O Boiling Point : 291.2°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :164.20Pubchem ID :135431271
Synonyms :

Computed Properties of [ 19178-21-3 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 19178-21-3 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 19178-21-3 ]

  • Upstream synthesis route of [ 19178-21-3 ]
  • Downstream synthetic route of [ 19178-21-3 ]

[ 19178-21-3 ] Synthesis Path-Upstream   1~7

  • 1
  • [ 68965-62-8 ]
  • [ 124-42-5 ]
  • [ 19178-21-3 ]
YieldReaction ConditionsOperation in experiment
71% With copper; sodium t-butanolate In N,N-dimethyl-formamide at 100℃; for 0.5 h; Microwave irradiation General procedure: A 10 mL microwave reaction tube was charged with the appropriate β-bromo α,β-unsaturated carboxylic acid 1 (0.5mmol) and amidine hydrochloride 2 (1 mmol), together withCu powder (0.05 mmol), t-BuONa (2 mmol), and DMF (3mL). The mixture was heated to 100 °C for 30 min by microwave irradiation (CEM Discover Microwave System) at 100 W initial power. The mixture was then cooled to r.t.and filtered through a short column of silica gel (CHCl3–MeOH) to remove inorganic salts. Evaporation of the solvent gave a crude mixture that was purified by TLC [silica gel 60 GF254 (Merck), CHCl3–MeOH].
Reference: [1] Applied Organometallic Chemistry, 2012, vol. 26, # 11, p. 576 - 582,7
[2] Synlett, 2013, vol. 24, # 20, p. 2705 - 2708
[3] Synlett, 2010, # 17, p. 2611 - 2616
  • 2
  • [ 124-42-5 ]
  • [ 19178-21-3 ]
Reference: [1] Patent: EP1142881, 2001, A1,
  • 3
  • [ 105550-62-7 ]
  • [ 19178-21-3 ]
Reference: [1] Synthesis, 1985, # 12, p. 1148 - 1149
  • 4
  • [ 124-42-5 ]
  • [ 1655-07-8 ]
  • [ 19178-21-3 ]
Reference: [1] Patent: US5234936, 1993, A,
  • 5
  • [ 143-37-3 ]
  • [ 1655-07-8 ]
  • [ 19178-21-3 ]
Reference: [1] Journal of the American Chemical Society, 1952, vol. 74, p. 842
[2] Journal of the American Chemical Society, 1958, vol. 80, p. 6609,6611
  • 6
  • [ 62360-62-7 ]
  • [ 19178-21-3 ]
Reference: [1] Tetrahedron Letters, 2014, vol. 55, # 2, p. 483 - 485
  • 7
  • [ 1404219-84-6 ]
  • [ 19178-21-3 ]
Reference: [1] Tetrahedron Letters, 2014, vol. 55, # 2, p. 483 - 485
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