Home Cart 0 Sign in  
X

[ CAS No. 19314-10-4 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
3d Animation Molecule Structure of 19314-10-4
Chemical Structure| 19314-10-4
Chemical Structure| 19314-10-4
Structure of 19314-10-4 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 19314-10-4 ]

Related Doc. of [ 19314-10-4 ]

Alternatived Products of [ 19314-10-4 ]

Product Details of [ 19314-10-4 ]

CAS No. :19314-10-4 MDL No. :MFCD09878796
Formula : C9H10ClNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :QMHVIXPPSYYGJY-UHFFFAOYSA-N
M.W : 199.63 Pubchem ID :3008381
Synonyms :

Safety of [ 19314-10-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 19314-10-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 19314-10-4 ]
  • Downstream synthetic route of [ 19314-10-4 ]

[ 19314-10-4 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 19314-10-4 ]
  • [ 54197-66-9 ]
YieldReaction ConditionsOperation in experiment
87% at 210℃; for 0.166667 h; Neat (no solvent) p-Aminophenol [0.5 gm (4.58 mmol)] was dissolved in 30 ml of each methylene chloride and saturated aqueous bicarbonate solution and stirred for 5 minutes at ambient temperature. 3-Chloropropionyl chloride [0.49 ml (5.04 mmol.)] was added over 10 min. and the reaction mixture was stirred at ambient temperature for 4 hrs. A large amount of precipitate was observed. The solids were filtered and dried to afford 0.82 gm ( 90 percent) of an off-white solid. MS APCI m/e 200 (p+1). This product (0.82 gm (4.1 mmol.)) was combined with 1.6 gm (12.3 mmol.) aluminum chloride as a mixture of solids. The mixture was then heated in an oil bath at 210 °C for 10 minutes or until the gas evolution ceases. The reaction mixture was then allowed to cool to ambient temperature and then quenched in an ice/water mixture. The aqueous phase was extracted with ethyl acetate which was separated, dried over sodium sulfate and evaporated in vacuo to a light brown solid 0.58 gm (87 percent) MS APCI m/e 164 (p+1).
Reference: [1] Patent: EP1175417, 2004, B1, . Location in patent: Page 27
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 14, p. 3546 - 3560
[3] Chemische Berichte, 1927, vol. 60, p. 861
[4] Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 15, p. 339
Recommend Products
Same Skeleton Products
Historical Records

Related Functional Groups of
[ 19314-10-4 ]

Aryls

Chemical Structure| 50297-40-0

[ 50297-40-0 ]

3-Chloro-N-(3-hydroxyphenyl)propanamide

Similarity: 0.98

Chemical Structure| 19313-87-2

[ 19313-87-2 ]

3-Chloro-N-(4-methoxyphenyl)propanamide

Similarity: 0.92

Chemical Structure| 21261-76-7

[ 21261-76-7 ]

3-Chloro-N-(3-methoxyphenyl)propanamide

Similarity: 0.90

Chemical Structure| 915923-51-2

[ 915923-51-2 ]

3-Chloro-N-(3,5-dimethoxyphenyl)propanamide

Similarity: 0.88

Chemical Structure| 893725-93-4

[ 893725-93-4 ]

N-(4-Acetamidophenyl)-3-chloropropanamide

Similarity: 0.87

Chlorides

Chemical Structure| 50297-40-0

[ 50297-40-0 ]

3-Chloro-N-(3-hydroxyphenyl)propanamide

Similarity: 0.98

Chemical Structure| 19313-87-2

[ 19313-87-2 ]

3-Chloro-N-(4-methoxyphenyl)propanamide

Similarity: 0.92

Chemical Structure| 21261-76-7

[ 21261-76-7 ]

3-Chloro-N-(3-methoxyphenyl)propanamide

Similarity: 0.90

Chemical Structure| 915923-51-2

[ 915923-51-2 ]

3-Chloro-N-(3,5-dimethoxyphenyl)propanamide

Similarity: 0.88

Chemical Structure| 893725-93-4

[ 893725-93-4 ]

N-(4-Acetamidophenyl)-3-chloropropanamide

Similarity: 0.87

Amides

Chemical Structure| 50297-40-0

[ 50297-40-0 ]

3-Chloro-N-(3-hydroxyphenyl)propanamide

Similarity: 0.98

Chemical Structure| 19313-87-2

[ 19313-87-2 ]

3-Chloro-N-(4-methoxyphenyl)propanamide

Similarity: 0.92

Chemical Structure| 21261-76-7

[ 21261-76-7 ]

3-Chloro-N-(3-methoxyphenyl)propanamide

Similarity: 0.90

Chemical Structure| 915923-51-2

[ 915923-51-2 ]

3-Chloro-N-(3,5-dimethoxyphenyl)propanamide

Similarity: 0.88

Chemical Structure| 893725-93-4

[ 893725-93-4 ]

N-(4-Acetamidophenyl)-3-chloropropanamide

Similarity: 0.87

Amines

Chemical Structure| 50297-40-0

[ 50297-40-0 ]

3-Chloro-N-(3-hydroxyphenyl)propanamide

Similarity: 0.98

Chemical Structure| 19313-87-2

[ 19313-87-2 ]

3-Chloro-N-(4-methoxyphenyl)propanamide

Similarity: 0.92

Chemical Structure| 21261-76-7

[ 21261-76-7 ]

3-Chloro-N-(3-methoxyphenyl)propanamide

Similarity: 0.90

Chemical Structure| 915923-51-2

[ 915923-51-2 ]

3-Chloro-N-(3,5-dimethoxyphenyl)propanamide

Similarity: 0.88

Chemical Structure| 893725-93-4

[ 893725-93-4 ]

N-(4-Acetamidophenyl)-3-chloropropanamide

Similarity: 0.87