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Chemical Structure| 1942919-79-0 Chemical Structure| 1942919-79-0

Structure of NVP-BSK805 2HCl
CAS No.: 1942919-79-0

Chemical Structure| 1942919-79-0

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NVP-BSK805 2HCl is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM and > 20-fold selectivity towards JAK1, JAK3 and TYK2.

Synonyms: NVP-BSK805 (hydrochloride); BSK805; NVP-BSK805 dihydrochloride

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Product Details of NVP-BSK805 2HCl

CAS No. :1942919-79-0
Formula : C27H30Cl2F2N6O
M.W : 563.47
SMILES Code : FC1=C(C(F)=CC(C2=C3N=C(C4=CN(C5CCNCC5)N=C4)C=NC3=CC=C2)=C1)CN6CCOCC6.[H]Cl.[H]Cl
Synonyms :
NVP-BSK805 (hydrochloride); BSK805; NVP-BSK805 dihydrochloride
MDL No. :MFCD22420810

Safety of NVP-BSK805 2HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of NVP-BSK805 2HCl

epigenetics
RTK
JAK-STAT

Isoform Comparison

Biological Activity

Target
  • JAK1

    JAK1, IC50:31.63 nM

  • JAK3

    JAK3, IC50:18.68 nM

  • Tyk2

    TYK2, IC50:10.76 nM

  • JAK2

    JAK2, IC50:~0.5 nM

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.87mL

1.77mL

0.89mL

17.75mL

3.55mL

1.77mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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