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[ CAS No. 1950-85-2 ]

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Chemical Structure| 1950-85-2
Chemical Structure| 1950-85-2
Structure of 1950-85-2 * Storage: {[proInfo.prStorage]}

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Product Details of [ 1950-85-2 ]

CAS No. :1950-85-2 MDL No. :MFCD03425630
Formula : CH3NaO2S2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :134.15 g/mol Pubchem ID :23688755
Synonyms :

Safety of [ 1950-85-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1950-85-2 ]

  • Upstream synthesis route of [ 1950-85-2 ]
  • Downstream synthetic route of [ 1950-85-2 ]

[ 1950-85-2 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 20277-69-4 ]
  • [ 1950-85-2 ]
YieldReaction ConditionsOperation in experiment
77% With sulfur In methanol for 0.333333 h; Heating / reflux A mixture of sodium methanesulfinate (5.43 g, 53 mmol) and sulphur (1.666 g, 52 mmol) in dry methanol (310 ml) was heated to reflux for 20 min, at which time almost all of the sulphur had dissolved. The hot solution was filtered and the filtrate concentrated to dryness. The off-white solid was stirred with a small amount of dry ethanol 0 at room temperature, filtered and concentrated. The trituration was repeated until 1H NMR of the white residue showed no more traces of sodium methanethiosulfonate. The filtrates were then combined and evaporated to dryness to yield the title compound (5.40 g, 77percent) as fine EPO <DP n="41"/>white needles; mp 271-2720C (lit.[G.L. Kenyon, T. W. Bruice, Methods Enzymol. 1977, 47, 407-430.] 272-273.50C); 1H NMR (200 MHz, CDCl3) δ 3.18 (s, 3H, CH3); anal, calculated, for CH3NaO2S2: C 8.95, H 2.25; found: C 8.86, H 2.55.; Improved Synthesis for NaMTS EPO <DP n="40"/>[0136] An alternative preparation of NaMTS (J.D. Macke, L. Field, /. Org. Chem. 1988, 53, 396-402) has been successfully tested, which is faster and avoids the tedious and lengthy separation of by-product from NaMTS as required in the Na2SZMe3SiCl method. NaMTS was synthesized in high yield by refluxing sodium sulfinate with sulphur in methanol s (Scheme 16, Fig. 19), described in further detail below). Although formation of small amounts of an unknown by-product was observed, it could be easily separated from NaMTS.
Reference: [1] Chemistry Letters, 1987, p. 2161 - 2162
[2] Patent: WO2006/55437, 2006, A2, . Location in patent: Page/Page column 38; 39; sheet 23
[3] Journal of Organic Chemistry, 2005, vol. 70, # 24, p. 9740 - 9754
[4] Dalton Transactions, 2011, vol. 40, # 45, p. 12310 - 12319
[5] Journal of Organic Chemistry, 1988, vol. 53, # 2, p. 396 - 402
  • 2
  • [ 124-63-0 ]
  • [ 1950-85-2 ]
Reference: [1] Journal of Organic Chemistry, 2005, vol. 70, # 24, p. 9740 - 9754
[2] Chemical Communications, 2007, # 30, p. 3145 - 3147
[3] Synthetic Communications, 2008, vol. 38, # 21, p. 3726 - 3750
[4] Patent: WO2006/134489, 2006, A1, . Location in patent: Page/Page column 15-17
[5] Patent: EP1832575, 2007, A1, . Location in patent: Page/Page column 3-4
[6] Patent: EP1980559, 2008, A1, . Location in patent: Page/Page column 9-10
[7] Carbohydrate Research, 2009, vol. 344, # 13, p. 1758 - 1763
[8] Patent: US2010/168216, 2010, A1, . Location in patent: Page/Page column 4
[9] Patent: EP1939186, 2008, A1, . Location in patent: Page/Page column 6
[10] Patent: WO2008/146105, 2008, A1, . Location in patent: Page/Page column 20-23
  • 3
  • [ 2386-57-4 ]
  • [ 1950-85-2 ]
Reference: [1] Patent: US2009/275721, 2009, A1,
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