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[ CAS No. 1951-26-4 ]

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1951-26-4
Chemical Structure| 1951-26-4
Structure of 1951-26-4 * Storage: {[proInfo.prStorage]}

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Product Details of [ 1951-26-4 ]

CAS No. :1951-26-4 MDL No. :MFCD02675787
Formula : C19H16I2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :546.14 g/mol Pubchem ID :-
Synonyms :

Safety of [ 1951-26-4 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1951-26-4 ]

  • Upstream synthesis route of [ 1951-26-4 ]
  • Downstream synthetic route of [ 1951-26-4 ]

[ 1951-26-4 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 869-24-9 ]
  • [ 1951-26-4 ]
  • [ 19774-82-4 ]
YieldReaction ConditionsOperation in experiment
87.6% With potassium carbonate In water; toluene for 4 h; 130.0 g (0.238 mol) of the compound of formula 7 and 43.4 g (0.2523 mol) of 2-chloro-N,N-diethylethanamine hydrochloride,98.9g (0.7164mol) of potassium carbonate, 208g of water, and 495g of toluene were mixed, mechanically stirred, and the reaction was heated for 4 hours.Let stand, layer, wash the organic phase 2 times, adjust the pH of the organic phase with HCl to 1-2, -0.09 to -0.08 MPa/40-65°C, and distill off the solvent.The crude amiodarone hydrochloride of Formula 1 was obtained in an amount of 162.4 g in a yield of 100percent (based on the compound represented by Formula 7).Take 50g crude amiodarone, dissolve it in 100g dichloromethane, pass the silica gel (400g) column,The column was flushed with a mixture of 450 g of dichloromethane and 70 g of methanol containing the amiodarone hydrochloride effluent.Evaporation of the solvent gave amiodarone hydrochloride 45 g of a refined product, which was refined by refluxing with 450 g of acetone and dried to obtain 43.8 g of amiodarone hydrochloride with a refined yield of 87.6percent.
Reference: [1] Patent: CN107382925, 2017, A, . Location in patent: Paragraph 0098-0100
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