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Product Details of [ 19520-75-3 ]

CAS No. :19520-75-3 MDL No. :MFCD06655980
Formula : C8H8O4 Boiling Point : -
Linear Structure Formula :- InChI Key :TUUBOHWZSQXCSW-UHFFFAOYSA-N
M.W : 168.15 Pubchem ID :7472024
Synonyms :

Safety of [ 19520-75-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 19520-75-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 19520-75-3 ]
  • Downstream synthetic route of [ 19520-75-3 ]

[ 19520-75-3 ] Synthesis Path-Upstream   1~11

  • 1
  • [ 19520-75-3 ]
  • [ 57179-35-8 ]
Reference: [1] Chemische Berichte, 1941, vol. 74, p. 1424,1428
[2] Journal fuer Praktische Chemie (Leipzig), 1927, vol. <2> 116, p. 323
  • 2
  • [ 19520-74-2 ]
  • [ 19520-75-3 ]
YieldReaction ConditionsOperation in experiment
98% With sodium hydroxide In methanol at 45℃; Inert atmosphere General procedure: To the solution of 3a (4.5 g, 16.7 mmol) in methanol (30 mL) was added 1 M sodium hydroxide (60 mL, 60 mmol), stirred at 45°C for 1-2 hours under nitrogen, monitored by TLC, followed by addition of 1 M hydrochloric acid (50 mL) to acidify the solution and extracted with ethyl acetate (3 × 50 mL). The combined organic layers was washed with distilled water (2 × 30 mL) and dried over sodium sulfate. The solvent was evaporated under reduced pressure to afford 5a as an off-white solid (4.02 g, 94percent), mp 196-198°C. 1H NMR (400 MHz, Acetone-d6) δ (ppm) 7.42-7.33 (5H, m, benzyl Ph), 7.21 (1H, dd, J=2.4, 1.2 Hz, H-2), 7.11 (1H, dd, J=2.4, 1.2 Hz, H-6), 6.68 (1H, t, J=2.4 Hz, H-4), 5.07 (2H, s, benzyl CH2). The 1H NMR spectrum was in good agreement with previously reported data[38].
Reference: [1] European Journal of Medicinal Chemistry, 2013, vol. 63, p. 415 - 422
[2] Journal of the American Chemical Society, 2005, vol. 127, # 6, p. 1737 - 1743
[3] Acta Phytochimica, 1939, vol. 11, p. 167,179
[4] Acta Phytochimica, 1939, vol. 11, p. 167,179
  • 3
  • [ 2150-44-9 ]
  • [ 19520-75-3 ]
Reference: [1] Journal of the American Chemical Society, 2005, vol. 127, # 6, p. 1737 - 1743
[2] European Journal of Medicinal Chemistry, 2013, vol. 63, p. 415 - 422
  • 4
  • [ 64-17-5 ]
  • [ 1132-21-4 ]
  • [ 19520-75-3 ]
  • [ 17275-82-0 ]
  • [ 84542-51-8 ]
Reference: [1] Liebigs Annalen der Chemie, 1982, vol. No. 12, p. 2189 - 2215
  • 5
  • [ 99-10-5 ]
  • [ 19520-75-3 ]
Reference: [1] European Journal of Medicinal Chemistry, 2013, vol. 63, p. 415 - 422
  • 6
  • [ 2150-44-9 ]
  • [ 77-78-1 ]
  • [ 19520-75-3 ]
Reference: [1] Chemische Berichte, 1941, vol. 74, p. 1424,1428
[2] Journal fuer Praktische Chemie (Leipzig), 1927, vol. <2> 116, p. 323
[3] Arzneimittel-Forschung/Drug Research, 1988, vol. 38, # 4, p. 501 - 507
  • 7
  • [ 1132-21-4 ]
  • [ 19520-75-3 ]
Reference: [1] RSC Advances, 2015, vol. 5, # 64, p. 52007 - 52018
  • 8
  • [ 99-10-5 ]
  • [ 77-78-1 ]
  • [ 19520-75-3 ]
Reference: [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980, p. 1658 - 1666
  • 9
  • [ 7664-93-9 ]
  • [ 11029-16-6 ]
  • [ 19520-75-3 ]
  • [ 63992-61-0 ]
  • [ 73855-53-5 ]
Reference: [1] Biochemical Journal, 1939, vol. 33, p. 579,585[2] Biochemical Journal, 1947, vol. 41, p. 458,460
  • 10
  • [ 67-56-1 ]
  • [ 19520-75-3 ]
  • [ 19520-74-2 ]
Reference: [1] Gazzetta Chimica Italiana, 1981, vol. 111, # 9/10, p. 383 - 390
[2] Australian Journal of Chemistry, 1973, vol. 26, p. 2257 - 2275
[3] Australian Journal of Chemistry, 1973, vol. 26, p. 2277 - 2290
[4] Journal of Medicinal Chemistry, 2005, vol. 48, # 9, p. 3290 - 3312
[5] Angewandte Chemie - International Edition, 2016, vol. 55, # 27, p. 7821 - 7825[6] Angew. Chem., 2016, vol. 128, p. 7952 - 7956,5
  • 11
  • [ 186581-53-3 ]
  • [ 19520-75-3 ]
  • [ 19520-74-2 ]
Reference: [1] Liebigs Annalen der Chemie, 1982, vol. No. 12, p. 2189 - 2215
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