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[ CAS No. 196404-55-4 ] {[proInfo.proName]}

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Chemical Structure| 196404-55-4
Chemical Structure| 196404-55-4
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Product Details of [ 196404-55-4 ]

CAS No. :196404-55-4 MDL No. :MFCD09837613
Formula : C22H25NO6 Boiling Point : -
Linear Structure Formula :- InChI Key :MSVWUXLRSKRKFZ-PAMZHZACSA-N
M.W : 399.44 Pubchem ID :11165464
Synonyms :

Safety of [ 196404-55-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 196404-55-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 196404-55-4 ]
  • Downstream synthetic route of [ 196404-55-4 ]

[ 196404-55-4 ] Synthesis Path-Upstream   1~10

  • 1
  • [ 1531632-32-2 ]
  • [ 196404-55-4 ]
YieldReaction ConditionsOperation in experiment
67.9% With hydrogen; palladium(II) hydroxide In methanol at 20℃; for 1 h; 10141] The product obtained in the previous step (4.83 g,9.88 mmol) was dissolved in 10 ml of methanol, into which1.0 g of palladium hydroxide was added. Hydrogen wasintroduced (20 psi) at room temperature and reacted forabout 1 h, the completion of the reaction was monitored by TLC. The reaction liquid was filtered, concentrated, separated and purified by column chromatography (petroleum ether/ethyl acetate=5:1), to give the final product as a white solid (2.68 g, 67.9percent).
67.9% With hydrogen; palladium(II) hydroxide In methanol at 20℃; for 1 h; h. Preparation of (4S,5R)-3-t-butoxy carbonyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidine carboxylic acid (0164) methanol, into which 1.0 g of palladium hydroxide was added. Hydrogen was introduced (20 psi) at room temperature and reacted for about 1 h, the completion of the reaction was monitored by TLC. The reaction liquid was filtered, concentrated, separated and purified by column chromatography (petroleum ether/ethyl acetate=5:1), to give the final product as a white solid (2.68 g, 67.9percent).
Reference: [1] Patent: US2016/340365, 2016, A1, . Location in patent: Paragraph 0140; 0141
[2] Patent: US2016/297784, 2016, A1, . Location in patent: Paragraph 0149; 0164; 0165
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 194 - 203
  • 2
  • [ 670254-71-4 ]
  • [ 196404-55-4 ]
YieldReaction ConditionsOperation in experiment
92% at 20℃; The above mention product 7 dissolved with ΜeOΗ, added dilute NaOH and stir at room temperature, TLC has been monitored after completion of the reaction and remove MeOH, the residue is diluted with Ac0Et / H20, static stratification. Into the aqueous phase added the AcOEt, and adjust the pH with dilute hydrochloric acid. The mixture is allowed to stand for separation, the organic phase has been separated, and the aqueous phase has been extracted with AcOEt, the combined organic phases are washed with water, dried over anhydrous MgS04, the solvent has been removed, and then obtained benzooxazoline carboxylic acid 8, yield of both steps is 92percent.
Reference: [1] Patent: CN106632297, 2017, A, . Location in patent: Paragraph 0021
[2] Journal of Heterocyclic Chemistry, 2005, vol. 42, # 4, p. 679 - 684
  • 3
  • [ 124605-42-1 ]
  • [ 196404-55-4 ]
Reference: [1] Journal of Heterocyclic Chemistry, 2005, vol. 42, # 4, p. 679 - 684
[2] Patent: CN106632297, 2017, A,
  • 4
  • [ 157240-36-3 ]
  • [ 196404-55-4 ]
Reference: [1] Journal of Heterocyclic Chemistry, 2005, vol. 42, # 4, p. 679 - 684
[2] Patent: CN106632297, 2017, A,
  • 5
  • [ 196929-85-8 ]
  • [ 196404-55-4 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 194 - 203
[2] Patent: US2016/297784, 2016, A1,
  • 6
  • [ 100-52-7 ]
  • [ 196404-55-4 ]
Reference: [1] Patent: US2016/340365, 2016, A1,
[2] Patent: US2016/297784, 2016, A1,
  • 7
  • [ 911199-15-0 ]
  • [ 196404-55-4 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 194 - 203
  • 8
  • [ 1219592-76-3 ]
  • [ 196404-55-4 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 194 - 203
  • 9
  • [ 878395-96-1 ]
  • [ 196404-55-4 ]
Reference: [1] Patent: US2016/297784, 2016, A1,
  • 10
  • [ 24424-99-5 ]
  • [ 196404-55-4 ]
Reference: [1] Patent: CN106632297, 2017, A,
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