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CAS No. :	3430-26-0
Formula :	C₆H₅Br₂N
M.W :	250.92
SMILES Code :	CC1=CC(Br)=NC=C1Br
MDL No. :	MFCD00234955
InChI Key :	WWJLJUAHQHXDGM-UHFFFAOYSA-N
Pubchem ID :	2734429

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Yield	Reaction Conditions	Operation in experiment
35%	With tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; at 90℃; for 16h;Inert atmosphere;	A mixture of 2,5-dibromo-4-methylpyridine (0.60 g, 2.39 mmol), <strong>[145214-05-7]2-(tributylstannyl)-1,3-oxazole</strong> (1.02 g, 2.86 mmol), and Pd(PPh3)4 (276.32 mg, 0.23 mmol) in dioxane (15 mL) was heated at 90 C. under nitrogen. After 16 h, the mixture was concentrated under vacuum, and the resulting residue was purified by flash column chromatography (1:3 ethyl acetate/petroleum ether) to afford 5-bromo-4-methyl-2-(1,3-oxazol-2-yl)pyridine (0.20 g, 35%) as a light yellow solid. LCMS (ESI) [M+H]+=239.0.
33%	With tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; at 90℃; for 16h;	A mixture of 2,5-dibromo-4-methylpyridine (1.2 g, 4.78 mmol), <strong>[145214-05-7]2-(tributylstannyl)-1,3-oxazole</strong> (2.06 g, 5.75 mmol) and tetrakis(triphenylphosphine)palladium (552 mg, 0.48 mmol) in 1,4-dioxane (30 mL) was stirred for 16 hours at 90 C. After filtration, the filtrate was concentrated under vacuum. The residue was purified on a silica gel column eluted with ethyl acetate/petroleum ether (1/2) to afford 5-bromo-4-methyl-2-(1,3-oxazol-2-yl)pyridine (380 mg, 33%) as a light yellow solid. LCMS (ESI) [M+H+]=241.1.

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CAS No.: 3430-26-0

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CAS No.: 3430-26-0

Alternative Products

Product Details of 2,5-Dibromo-4-methylpyridine

Safety of 2,5-Dibromo-4-methylpyridine

Application In Synthesis of 2,5-Dibromo-4-methylpyridine

[ 3430-26-0 ] Synthesis Path-Downstream 1~1

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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
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H242	Heating may cause a fire
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H261	In contact with water releases flammable gas
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