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Chemical Structure| 202395-72-0 Chemical Structure| 202395-72-0

Structure of 202395-72-0

Chemical Structure| 202395-72-0

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Product Details of [ 202395-72-0 ]

CAS No. :202395-72-0
Formula : C7H7Cl2NO
M.W : 192.04
SMILES Code : COCC1=CN=C(Cl)C(Cl)=C1
English Name :2,3-Dichloro-5-(methoxymethyl)pyridine
MDL No. :MFCD26398496

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Application In Synthesis of [ 202395-72-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 202395-72-0 ]

[ 202395-72-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 124-41-4 ]
  • [ 54127-31-0 ]
  • [ 202395-72-0 ]
  • 2
  • [ 54127-30-9 ]
  • [ 54127-31-0 ]
  • [ 202395-72-0 ]
YieldReaction ConditionsOperation in experiment
With thionyl chloride; In methanol; water; Example 1(a) Preparation of 2,3-dichloro-5-(methoxymethyl)pyridine Under argon and at room temperature, 4.14 g (23 mmol) of sodium methoxide (30 percent strength solution in methanol) was added dropwise within 5 minutes to a solution of 4.11 g (20.9 mmol) of <strong>[54127-31-0]2,3-dichloro-5-(chloromethyl)-pyridine</strong> [prepared from 2,3-dichloro-5-(hydroxymethyl)-pyridine by reaction with thionyl chloride] in 40 ml of methanol. The reaction mixture was subsequently heated to 60 C. for 3 hours. After the reaction had ended, the solvent was distilled off and the residue was admixed with 100 ml of water and extracted with dichloromethane (3*75 ml). The organic phase was dried over magnesium sulfate and evaporated. The yield of the product was 4.06 g (90.4 percent) of a yellow oil, purity (GC) 90.8 percent. For analysis, the product was chromotographed over silica gel using hexane/ethyl acetate (3:1). MS (m/z): 192 (M+); 176; 161; 148; 124; 112.
 

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