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Chemical Structure| 2041073-22-5 Chemical Structure| 2041073-22-5

Structure of GNF4877
CAS No.: 2041073-22-5

Chemical Structure| 2041073-22-5

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GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively

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Product Details of GNF4877

CAS No. :2041073-22-5
Formula : C25H27FN6O4
M.W : 494.52
SMILES Code : O=C([C@H]1CN(C2=C(NC(C3=NC(C4=CC(OC(C)C)=CC=C4F)=CN=C3N)=O)C=NC=C2)CCC1)O
MDL No. :MFCD00078579
InChI Key :UZIATSFXNVOVFE-OAHLLOKOSA-N
Pubchem ID :139600315

Safety of GNF4877

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of GNF4877

RTK
PI3K-AKT
Hedgehog

Isoform Comparison

Biological Activity

Description
GNF4877 is a highly potent inhibitor of DYRK1A and GSK3β, with IC50 values of 6 nM and 16 nM, respectively. This inhibition results in the prevention of nuclear factor of activated T-cells (NFATc) nuclear export and enhanced β-cell proliferation (with an EC50 of 0.66 μM for mouse β (R7T1) cells) [1].

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1 mM

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10 mM

2.02mL

0.40mL

0.20mL

10.11mL

2.02mL

1.01mL

20.22mL

4.04mL

2.02mL

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