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Chemical Structure| 205754-33-2 Chemical Structure| 205754-33-2

Structure of 8-Hydroxyefavirenz
CAS No.: 205754-33-2

Chemical Structure| 205754-33-2

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8-Hydroxyefavirenz is a major metabolite of Efavirenz, which induces apoptosis in human primary hepatocytes through JNK and BimEL-dependent mechanisms. This compound is suitable for cancer research, particularly in studies exploring mechanisms of tumor cell death.

Synonyms: 8-OH-EFV

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Product Details of 8-Hydroxyefavirenz

CAS No. :205754-33-2
Formula : C14H9ClF3NO3
M.W : 331.67
SMILES Code : ClC1=CC(O)=C2C([C@@](C(F)(F)F)(OC(N2)=O)C#CC3CC3)=C1
Synonyms :
8-OH-EFV
MDL No. :N/A

Safety of 8-Hydroxyefavirenz

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H360-H410
Precautionary Statements:P201-P202-P264-P270-P273-P280-P301+P312+P330-P308+P313-P391-P405-P501
Class:9
UN#:3077
Packing Group:

Related Pathways of 8-Hydroxyefavirenz

MAPK
TLR

Isoform Comparison

Biological Activity

Description
8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of Efavirenz. It induces apoptosis in primary human hepatocytes via a JNK- and BimEL-dependent mechanism. This compound is utilized in cancer research [1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.02mL

0.60mL

0.30mL

15.08mL

3.02mL

1.51mL

30.15mL

6.03mL

3.02mL

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