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[ CAS No. 2090149-31-6 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 2090149-31-6
Chemical Structure| 2090149-31-6
Structure of 2090149-31-6 * Storage: {[proInfo.prStorage]}
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Product Details of [ 2090149-31-6 ]

CAS No. :2090149-31-6 MDL No. :
Formula : C7H4ClN3O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :197.58 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 2090149-31-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2090149-31-6 ]

[ 2090149-31-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 175867-01-3 ]
  • [ 2090149-31-6 ]
  • [ 2597936-05-3 ]
YieldReaction ConditionsOperation in experiment
58% With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 25℃; for 2h; 3 Step 3:
2-Chloro-N-((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)-5H-pyrrolo[3,2-d]pyrimidine-4-carboxamide A solution of 2-chloro-5H-pyrrolo[3,2-d]pyrimidine-4-carboxylic acid (2.3 g, 11.64 mmol, 1.0 eq), DIPEA (4.49 g, 34.74 mmol, 2.9 eq), HATU (5.30 g, 13.94 mmol, 1.2 eq) and Int B1 (2.40 g, 13.85 mmol, 1.2 eq) in DMF (20 mL) was stirred for 2 h at 25° C. The reaction was quenched with water and extracted with 3*100 mL of dichloromethane. The organic layers were combined, dried over sodium sulfate and concentrated under vacuum. The crude product was purified by re-crystallization from MeOH to afford the title compound (2.4 g, 58% yield) as a yellow solid. LCMS: [M+H]+ 353.13.
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