There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Structure of Brigimadlin
CAS No.: 2095116-40-6
*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Brigimadlin (BI 907828) is an orally active E3 ubiquitin ligase MDM-2 inhibitor that blocks MDM-2's negative regulation of the tumor suppressor p53. It is suitable for antitumor research.
Synonyms: BI 907828
4.5
*For Research Use Only !
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 2095116-40-6 |
Formula : | C31H25Cl2FN4O3 |
M.W : | 591.46 |
SMILES Code : | O=C(C1=C(C)C2=NN3C(C[C@@](N4CC5CC5)([H])[C@]3([H])[C@H](C6=CC=CC(Cl)=C6F)[C@@]74C(NC8=C7C=CC(Cl)=C8)=O)=C2C=C1)O |
Synonyms : |
BI 907828
|
MDL No. : | N/A |
GHS Pictogram: |
![]() ![]() |
Signal Word: | Danger |
Hazard Statements: | H300-H360-H372-H413 |
Precautionary Statements: | P260-P264-P270-P273-P280-P321-P330-P405-P501 |
Class: | 6.1 |
UN#: | 2811 |
Packing Group: | Ⅲ |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT06619509 | Solid Tumours | PHASE2 | RECRUITING | 2036-12-31 | Sanatorio Finochietto, Caba, C... More >>1120AAB, Argentina|Prince of Wales Hospital-Randwick-66496, Randwick, New South Wales, 2031, Australia|Princess Alexandra Hospital, Woolloongabba, Queensland, 4102, Australia|Peter MacCallum Cancer Centre, Melbourne, Victoria, 3000, Australia|Brussels - UNIV Saint-Luc, Bruxelles, 1200, Belgium|UZ Leuven, Leuven, 3000, Belgium|H.S.J. Beneficência Portuguesa - S?o Paulo, Sao Paulo, 01323-001, Brazil|West China Hospital, Chengdu, 610041, China|Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China|Copenhagen University Hospital, Rigshospitalet, K?benhavn ?, 2100, Denmark|Helios Klinikum Berlin-Buch, Berlin, 13125, Germany|Universit?tsklinikum Frankfurt, Frankfurt, 60590, Germany|Universit?tsklinikum Tübingen, Tübingen, 72076, Germany|Clinexpert Gyongyos, Gyongyos, 3200, Hungary|Sourasky Medical Center, Tel-Aviv, 6423906, Israel|Nagoya University Hospital, Aichi, Nagoya, 466-8560, Japan|National Hospital Organization Kyushu Cancer Center, Fukuoka, Fukuoka, 811-1395, Japan|Kyushu University Hospital, Fukuoka, Fukuoka, 812-8582, Japan|Tohoku University Hospital, Miyagi, Sendai, 980-8574, Japan|Okayama University Hospital, Okayama, Okayama, 700-8558, Japan|Osaka International Cancer Institute, Osaka, Osaka, 541-8567, Japan|National Cancer Center Hospital, Tokyo, Chuo-ku, 104-0045, Japan|Oncology Center-Maria Sklodowska-Curie Institute, Warsaw, 02-781, Poland|Hospital Duran i Reynals, L'Hospitalet de Llobregat, 08907, Spain|Fundación Jiménez Díaz, Madrid, 28040, Spain|Hospital Clínico San Carlos, Madrid, 28040, Spain|Hospital Universitario 12 de Octubre, Madrid, 28041, Spain|Hospital Universitario HM Sanchinarro, Madrid, 28050, Spain|Hospital Clínico de Santiago, Santiago de Compostela, 15706, Spain|Karolinska Comprehensive Cancer Center, Stockholm, 171 76, Sweden|The Royal Marsden Hospital, Chelsea, London, SW3 6JJ, United Kingdom Less << |
NCT03449381 | Neoplasms | PHASE1 | ACTIVE_NOT_RECRUITING | 2025-06-30 | Sarcoma Oncology Center, Santa... More >> Monica, California, 90403, United States|Yale University School of Medicine, New Haven, Connecticut, 06511, United States|Florida Cancer Specialists-Sarasota-61670, Sarasota, Florida, 34232, United States|Norton Cancer Institute, Downtown, Louisville, Kentucky, 40202, United States|START Midwest, Grand Rapids, Michigan, 49546, United States|Memorial Sloan-Kettering Cancer Center, New York, New York, 10065, United States|SCRI Oncology Partners, Nashville, Tennessee, 37203, United States|The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, United States|University of Wisconsin, Madison, Wisconsin, 53792, United States|Brussels - UNIV Saint-Luc, Bruxelles, 1200, Belgium|UZ Leuven, Leuven, 3000, Belgium|The Ottawa Hospital, Ottawa, Ontario, K1H 8L6, Canada|Rigshospitalet, K?benhavn, K?benhavn ?, 2100, Denmark|Helios Klinikum Berlin-Buch, Berlin, 13125, Germany|Universit?tsmedizin G?ttingen, Georg-August-Universit?t, G?ttingen, 37075, Germany|Universit?tsklinikum K?ln (A?R), K?ln, 50937, Germany|Universit?tsklinikum Tübingen, Tübingen, 72076, Germany|Sourasky Medical Center, Tel Aviv, 6423906, Israel|National Cancer Center Hospital, Tokyo, Chuo-ku, 104-0045, Japan|Severance Hospital, Seoul, 03722, Korea, Republic of|MED POLONIA SP Z O O, Clinical Trials Department,Poznan, Poznan, 60-693, Poland|Oncology Center-Maria Sklodowska-Curie Institute, Warsaw, 02-781, Poland|Hospital Vall d'Hebron-Barcelona-47683, Barcelona, 08035, Spain|Hospital Clínic de Barcelona, Barcelona, 08036, Spain|Fundación Jiménez Díaz, Madrid, 28040, Spain|Hospital Clínico de Santiago, Santiago de Compostela, 15706, Spain|Karolinska Comprehensive Cancer Center, Stockholm, 171 76, Sweden Less << |
NCT06058793 | Liposarcoma, Dedifferentiated | PHASE3 | ACTIVE_NOT_RECRUITING | 2025-11-30 | University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35249, United States|Mayo Clinic-Arizona, Phoenix, Arizona, 85054, United States|Precision NextGen Oncology, Beverly Hills, California, 90212, United States|Sarcoma Oncology Center, Santa Monica, California, 90403, United States|University of California Los Angeles, Santa Monica, California, 90404, United States|Yale Cancer Center, New Haven, Connecticut, 06510, United States|Mayo Clinic - Florida, Jacksonville, Florida, 32224, United States|University Cancer and Blood Center, Athens, Georgia, 30607, United States|Northwestern University, Chicago, Illinois, 60611, United States|University of Kansas Cancer Center, Overland Park, Kansas, 66210, United States|Mayo Clinic, Rochester, Rochester, Minnesota, 55905, United States|Washington University School of Medicine, Saint Louis, Missouri, 63110, United States|Nebraska Methodist Hospital, Omaha, Nebraska, 68114, United States|John Theurer Cancer Center, Hackensack, New Jersey, 07601, United States|Northwell Health, Lake Success, New York, 11042, United States|Memorial Sloan-Kettering Cancer Center, New York, New York, 10065, United States|Duke University Medical Center, Durham, North Carolina, 27710, United States|Abramson Cancer Center at Pennsylvania Hospital, Philadelphia, Pennsylvania, 19106, United States|West Cancer Center & Research Institute, Germantown, Tennessee, 38138, United States|The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, United States|Utah Cancer Specialists Cancer Center, Salt Lake City, Utah, 84106, United States|Huntsman Cancer Institute, Salt Lake City, Utah, 84112, United States|Virginia Cancer Specialists, PC, Fairfax, Virginia, 22031, United States|Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States|Medical Oncology Associates, P.S., Spokane, Washington, 99208, United States|Froedtert and The Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, United States|Sanatorio Finochietto, Caba, C1120AAB, Argentina|Prince of Wales Hospital-Randwick-66496, Randwick, New South Wales, 2031, Australia|Princess Alexandra Hospital, Woolloongabba, Queensland, 4102, Australia|Peter MacCallum Cancer Centre, Melbourne, Victoria, 3000, Australia|Sir Charles Gairdner Hospital, Nedlands, Western Australia, 6009, Australia|Hospital do Cancer de Londrina, Londrina, 86015-520, Brazil|OncoClinicas Rio de Janeiro, Rio de Janeiro, 22250-040, Brazil|CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia, Santo André, 09060-650, Brazil|ICESP - Instituto do Cancer do Estado de Sao Paulo, Sao Paulo, 01246-000, Brazil|H.S.J. Beneficência Portuguesa - S?o Paulo, Sao Paulo, 01323-001, Brazil|A.C. Camargo, Sao Paulo, 01509-900, Brazil|Arthur J. E. Child Comprehensive Cancer Centre, Calgary, Alberta, T2N 5G2, Canada|BC Cancer Agency - Vancouver Island Centre, Victoria, British Columbia, V8R 6V5, Canada|Princess Margaret Cancer Centre, Toronto, Ontario, M5G 2M9, Canada|Aichi Cancer Center Hospital, Aichi, Nagoya, 464-8681, Japan|Nagoya University Hospital, Aichi, Nagoya, 466-8560, Japan|National Cancer Center Hospital East, Chiba, Kashiwa, 277-8577, Japan|National Hospital Organization Kyushu Cancer Center, Fukuoka, Fukuoka, 811-1395, Japan|Kyushu University Hospital, Fukuoka, Fukuoka, 812-8582, Japan|Tohoku University Hospital, Miyagi, Sendai, 980-8574, Japan|Okayama University Hospital, Okayama, Okayama, 700-8558, Japan|Osaka International Cancer Institute, Osaka, Osaka, 541-8567, Japan|Hokkaido Cancer Center, Sapporo, Hokkaido, 003-0804, Japan|National Cancer Center Hospital, Tokyo, Chuo-ku, 104-0045, Japan|Japanese Foundation for Cancer Research, Tokyo, Koto-ku, 135-8550, Japan|Addenbrooke's Hospital, Cambridge, CB2 0QQ, United Kingdom|Beatson West of Scotland Cancer Centre, Glasgow, G12 0YN, United Kingdom|The Royal Marsden Hospital, Chelsea, London, SW3 6JJ, United Kingdom|The Christie, Manchester, M20 4BX, United Kingdom Less << |
Tags: Brigimadlin | BI 907828 | E1/E2/E3 Enzyme | Ubiquitin | 2095116-40-6
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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