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CAS No. : | 209960-29-2 | MDL No. : | MFCD09029885 |
Formula : | C10H13FN2O | Boiling Point : | 368.2±42.0°C at 760 mmHg |
Linear Structure Formula : | - | InChI Key : | N/A |
M.W : | 196.22 g/mol | Pubchem ID : | - |
Synonyms : |
|
Num. heavy atoms : | 14 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.4 |
Num. rotatable bonds : | 1 |
Num. H-bond acceptors : | 2.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 56.53 |
TPSA : | 38.49 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | Yes |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.65 cm/s |
Log Po/w (iLOGP) : | 1.84 |
Log Po/w (XLOGP3) : | 1.19 |
Log Po/w (WLOGP) : | 1.29 |
Log Po/w (MLOGP) : | 1.24 |
Log Po/w (SILICOS-IT) : | 1.63 |
Consensus Log Po/w : | 1.44 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.06 |
Solubility : | 1.72 mg/ml ; 0.00876 mol/l |
Class : | Soluble |
Log S (Ali) : | -1.59 |
Solubility : | 4.99 mg/ml ; 0.0254 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -2.51 |
Solubility : | 0.611 mg/ml ; 0.00311 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.68 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P280-P305+P351+P338-P310 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H332-H335 | Packing Group: | N/A |
GHS Pictogram: |
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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With dmap In dichloromethane at 20℃; for 12h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | With 5%-palladium/activated carbon; hydrogen In ethanol for 18h; | General procedure for the catalytic reduction of nitrobenzenes 8 and 12. General procedure: Palladium on carbon (5% w/w, 0.30 g) was added to a solution of the appropriate nitrobenzene (7.4 mmol) in ethanol (100 mL) and stirred under hydrogen (1 atm) for 18 h. The mixture was filtered through celite under an argon atmosphere, rinsing with ethanol. The filtrate was concentrated and dried in vacuo affording the crude aniline, which was used without purification.4-Morpholinoaniline 9 (from 8). lavender crystals yield 98%, mp 103.2-103.7 °C. 1H NMR (400 MHz, CDCl3) δ 2.97-3.06 (m, 4H), 3.44 (br s, 2H), 3.81-3.89 (m, 4H), 6.67 (d, J 8.6 Hz, 2H), 6.80 (d, J 9.0 Hz, 2H).2-Fluoro-4-morpholinoaniline (from 12). purple crystals, yield 97%. 1H NMR (400 MHz, CDCl3) δ 2.95-3.05 (m, 4H), 3.78-3.88 (m, 4H), 6.55 (d, J 8.6 Hz, 1H), 6.63 (dd, J 13.5, 2.2 Hz, 1H), 6.72 (t, J 9.4 Hz, 1H). |
96% | With iron(III)-acetylacetonate; hydrazine hydrate In methanol at 150℃; for 0.0333333h; Microwave irradiation; chemoselective reaction; | |
50% | With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; Flow reactor; |
8.4% | With hydrogen In methanol for 2.5h; | |
With hydrogen In methanol for 2h; | 224.B 1-(3-amidinophenyl)-3-methyl-5-[(3-fluoro-4-(N-morpholino)phenyl)aminocarbonyl]pyrazole bis-trifluoroacetate Part B. Preparation of N-(3-fluoro-4-aminophenyl)morpholine. N-(3-fluoro-4-nitrophenyl)morpholine (6.01 g,26.59 mmol) and a catalytic amount of palladium on carbon(10%) were suspended in 100 mL methanol in a Parr flask. The reaction mixture was placed on the Parr Hydrogenator at 60psi for 2H. The reaction mixture was passed through a Celite pad and the filtrate was concentrated under reduced pressure to give 4.50 g of N-(3-fluoro-4-aminophenyl)morpholine an off-colored solid. 1H-NMR(DMSO-d6) δ: 6.73 (t,1H, J = 9.34), 6.28 (m,2H), 3.64 (bt, 4H, J = 4.58Hz), 2.76 (bt, 4H, J = 4.58Hz). ESI mass spectrum analysis m/z (relative intensity) 197 (M+H, 100). 19FNMR(DMSO-d6) δ: -124.455. | |
With hydrogen In methanol for 2.5h; | 29 Preparation of 2-fluoro-4-morpholinoaniline 2-Fluoro-4-morpholinonitrobenzene (1.80 g) was dissolved in methanol (100 mL) and 10% Pd/C (94 mg) was added. The mixture was placed in a hydrogenator (45 psi) for 2.5 h. The reaction mixture was filtered through celite and washed with methanol. The filtrate was concentrated to give 1.51 g solid. 1H NMR (CDCl3) δ6.76-6.54 (m, 3H), 3.84 (t, 4H), 3.45 (bs, 2H), 3.02 (t, 4H) ppm. ESI mass spectrum z (rel. intensity) 197.1 (M+H, 100). | |
With hydrogen In methanol for 2.5h; | 29 2-Fluoro-4-morpholinonitrobenzene (1.80 g) was dissolved in methanol (100 mL) and 10% Pd/C (94 mg) was added. The mixture was placed in a hydrogenator (45 psi) for 2.5 h. The reaction mixture was filtered through celite and washed with methanol. The filtrate was concentrated to give 1.51 g solid.1H NMR (CDCl3) δ 6.76-6.54 (m, 3H), 3.84 (t, 4H), 3.45 (bs, 2H), 3.02 (t, 4H) ppm. ESI mass spectrum z (rel. intensity) 197.1 (M+H, 100). | |
With palladium on activated charcoal; hydrogen In methanol | ||
With palladium on activated charcoal; hydrogen In methanol at 20℃; for 3h; | 47.B Step B: Step B: 2-Fluoro-4-morpholine aniline To a solution of 4-(3-fluoro-4-nitrophenyl)morpholine (1.00g, 4.42mmol) in methanol (20mL) was added palladium carbon (517.41mg, 486.20μmol), and it was replaced three times with a hydrogen balloon and then stirred at room temperature for 3 hours. It was filtered with Celite and spin-dried to give the title compound. 1H NMR (400MHz, DMSO-d6) δ=6.73 - 6.63 (m, 2H), 6.54 (dd, J=1.9, 8.4 Hz, 1H), 4.58 (s, 2H), 3.74-3.65 (m, 4H), 2.97-2.85 (m, 4H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: (dimethylamino)pyridine / CH2Cl2 / 12 h / 20 °C 2.1: acetoxyhydroxamic acid; potassium tert-butoxide / dimethylformamide / 12 h / 20 °C 2.2: HCl / ethanol / 80 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 1.81 g / tetrahydrofuran / 2 h / 20 °C 2: 8.4 percent / H2 / Pd/C / methanol / 2.5 h / 2327.17 Torr | ||
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 80 °C 2: palladium on activated charcoal; hydrogen / methanol | ||
Multi-step reaction with 2 steps 1: ethanol / 0.17 h / 100 °C / 7500.75 Torr / Flow reactor 2: hydrogen; palladium 10% on activated carbon / ethanol / 50 °C / 760.05 Torr / Flow reactor |
Multi-step reaction with 2 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 80 °C 1.2: 16 h / 20 °C 2.1: palladium on activated charcoal; hydrogen / methanol / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
224.B 1-(3-amidinophenyl)-3-methyl-5-[(3-fluoro-4-(N-morpholino)phenyl) aminocarbonyl]pyrazole bis-trifluoroacetate Part B. Preparation of N-(3-fluoro-4-aminophenyl)morpholine. N-(3-fluoro-4-nitrophenyl)morpholine (6.01 g,26.59 mmol) and a catalytic amount of palladium on carbon(10%) were suspended in 100 mL methanol in a Parr flask. The reaction mixture was placed on the Parr Hydrogenator at 60 psi for 2 H. The reaction mixture was passed through a Celite pad and the filtrate was concentrated under reduced pressure to give 4.50 g of N-(3-fluoro-4-aminophenyl)morpholine an off-colored solid. 1 H-NMR(DMSO-d6) δ: 6.73 (t, 1 H, J=9.34), 6.28 (m, 2 H), 3.64 (bt, 4 H, J=4.58 Hz), 2.76 (bt, 4 H, J=4.58 Hz). ESI mass spectrum analysis m/z(relative intensity) 197 (M+H, 100). 19 FNMR(DMSO-d6) δ: -124.455. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate | A 1-(3-amidinophenyl)-3-trifluoromethyl-5-((2-fluoro-4-(N-morpholino)phenyl)aminocarbonyl)pyrazole bis-trifluoro acetate and 1-(3-Carboxamidophenyl)-3-trifluoromethyl-5-((2-fluoro-4-(N-morpholino)phenyl)aminocarbonyl) pyrazole Part A. Preparation of 2-fluoro-4-(-N-morpholino)aniline. Morpholine(10.0 mL,115 mmol) was added to a mixture of 4-bromo-2-fluoroaniline(1.03 g,5.42 mmol), copper(I) bromide (0.039 g,0.27 mmol) and potassium carbonate(1.50 g,10.84 mmol). The reaction mixture was heated to 130° C. for 48 h, concentrated under reduced pressure and purified by flash chromotography to afford 0.11 g of pure 2-fluoro-4-(-N-morpholino)aniline. 1 H-NMR(DMSO-d6) δ: 6.73 (dd, 1 H, J1 =8.8 Hz, J2 =9.9 Hz), 6.64 (dd, 1 H, J1 =2.6 Hz, J2 =13.2 Hz), 6.57 (m, 1 H), 3.85 (m, 4 H), 3.02 (m, 4 H). ESI mass spectrum analysis m/z(relative intensity) 197 (M+H, 100). 19 FNMR (dmso-d6,300 MHz) δ: -133. | |
With potassium carbonate at 130℃; for 48h; | 230.A; 231.A 1-(3-amidinophenyl)-3-trifluoromethyl-5-((2-fluoro-4-(N-morpholino)phanyl)aminocarbonyl)pyrazole bis-trifluoro acetate and 1-(3-Carboxamidophonyl)-3-trifluoramethyl-5-((2-fluoro-4-(N-morpholino)phenyl)aminocarbonyl) pyrazole Part A. Preparation of 2-fluoro-4-(-N-morpholino)aniline. Morpholine(10.0 mL,115 mmol) was added to a mixture of 4-bromo-2-fluoroaniline(1.03 g, 5.42 mmol), copper(I) bromide (0.039 g,0.27 mmol) and potassium carbonate(1.50 g,1.0.84 mmol). The reaction mixture was heated to 130°C for 48h, concentrated under reduced pressure and purified by flash chromotography to afford 0.11 g of pure 2-fluoro-4-(-N-morpholino) aniline. 1H-NMR(DMSO-d6) δ: 6.73 (dd, 1H, J1 = 8.8Hz, J2 = 9.9Hz), 6.64 (dd, 1H, J1 = 2.6Hz, J2 = 13.2Hz), 6.57 (m,1H), 3.85 (m,4H), 3.02 (m,4H). ESI mass spectrum analysis m/z(relative intensity) 197 (M+H, 100). 19FNMR (dmso-d6,300MHz) δ: -133. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: N-(3-fluoro-4-aminophenyl)morpholine; 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride With dmap Stage #2: acetone oxime With sodium t-butanolate Stage #3: trifluoroacetic acid With hydrogenchloride more than 3 stages; | 29 Preparation of 1-(3'-Aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[(3-fluoro-4-morpholinophenyl)aminocarbonyl]pyrazole The title compound was prepared from 1-(3-cyano-4-fluorophenyl)-3-trifluoromethyl-5-pyrazolecarboxylic acid and 2-fluoro-4-morpholinoaniline as a TFA salt by the same procedures described in Example 26. 1H NMR (DMSO-d6) δ9.39 (s, 1H), 8.06 (d, 1H), 7.77-7.48 (m, 4H), 6.81-6.75 (m, 2H), 3.77 (t, 4H), 3.15 (t, 4H) ppm. ESI mass spectrum z (rel. intensity) 491.2 (M+H, 100). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: N-(3-fluoro-4-aminophenyl)morpholine; C13H9ClFN3O With dmap Stage #2: acetone oxime With sodium t-butanolate Stage #3: trifluoroacetic acid With hydrogenchloride more than 3 stages; | 44 Example 44 1-(3'-Aminobenzisoxazol-5'-yl)-3-ethyl-5-[(2-fluoro-4-morpholinophenyl)aminocarbonyl]pyrazole The title compound was prepared in an analogous fashion as TFA salt. 1H NMR (acetone-d6) δ9.08 (s, 1H), 7.94 (d, 1H), 7.64 (m, 2H), 7.47 (d, 1H), 6.92 (s, 1H), 6.78 (m, 2H), 4.07 (bs, 2H), 3.77 (t, 4H), 3.1 (t, 4H), 2.70 (q, 2H), 1.28 (t, 3H) ppm. ESI mass spectrum z (rel. intensity) 451.2 (M+H, 100). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With dmap In dichloromethane at 20℃; for 72h; | 224.C 1-(3-amidinophenyl)-3-methyl-5-[(3-fluoro-4-(N-morpholino)phenyl)aminocarbonyl]pyrazole bis-trifluoroacetate Part C. Preparation of 1-(3-cyanophenyl)-3-methyl-5-((3-fluoro-4-(N-morpholino)phenyl)aminocarbonyl)pyrazole. Dimethylaminopyridine(0.28 g,2.25 mmol) was added to a solution of 1-(3-cyanophenyl)-3-methyl-pyrazole-5-carboxylic acid chloride (0.46 g,1.88 mmol) and N-(3-fluoro-4-aminophenyl)morpholine (0.37 g,1.88 mmol) in 20 mL methylene chloride. The reaction mixture was stirred at ambient temperature for 72H and then concentrated under reduced pressure. The resulting residue was purified via flash chromotography to give 0.070 g of pure 1-(3-cyanophenyl)-3-methyl-5-((3-fluoro-4-(N-morpholino)phenyl)aminocarbonyl)pyrazole. 1H-NMR(DMSO-d6) δ: 10.50 (s,1H) 7.93 (s,1H), 7.83 (d,1H, J = 7.33Hz), 7.73 (d, 1H, J = 8.79Hz), 7.62 (t, 1H, J = 7.87Hz), 7.53 (m,1H), 7.34 (d, 1H, J = 9.15Hz), 6.99 (t, 1H, J = 9.34Hz), 6.93 (s,1H), 3.69 (bt, 4H, J = 4.58Hz), 2.92 (bt, 4H, J = 4.58Hz), 2.28 (s,3H). ESI mass spectrum analysis m/z(relative intensity) 406 (M+H, 100), 833 (2M+Na). 19F NMR (dmso-d6,300MHz) δ: -122.081. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With dmap In dichloromethane at 20℃; for 20h; | 230.B; 231.B 1-(3-amidinophenyl)-3-trifluoromethyl-5-((2-fluoro-4-(N-morpholino)phanyl)aminocarbonyl)pyrazole bis-trifluoro acetate and 1-(3-Carboxamidophonyl)-3-trifluoramethyl-5-((2-fluoro-4-(N-morpholino)phenyl)aminocarbonyl) pyrazole Part B. Preparation of 1-(3-cyanophenyl)-3-trifluoromethyl-5-((2'-fluoro-4'-(N-morpholino)phenyl)aminocarbonyl)pyrazole. 2-Fluoro-4-(N-morpholino)aniline(0.11 g,0.56 mmol) in 5 mL methylene chloride was dripped into a stirring solution of N-(3-cyanophenyl)-3-trifluoromethyl-pyrazole-5-carboxylic acid chloride(0.17 g,0.56 mmol) and dimethylaminopyridine (0.082 g, 0.67 mmol) in 10 mL methylene chloride. The reaction mixture was stirred at ambient temperature for 20h. The reaction mixture was concentrated under reduced pressure and purified by flash chromatography to give 0.19 g of pure 1-(3-cyanophenyl)-3-trifluoromethyl-5-[(2'-fluoro-4'-(N-morpholino)phenyl)aminocarbonyl]pyrazole. 1H-NMR(DMSO-d6)δ:7.94 (m, 1H), 7.86 (s,1H), 7.77 (m,3H), 7.61 (dd, 2H, J1 = 7.7Hz, J2 = 8.1Hz), 7.12 (s,1H), 3.85 (m,4H), 3.14 (m,4H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: ethanol / 80 °C 2: 1-butyl-3-methylimidazolium hydroxide / 6 h / 20 °C 3: 1-butyl-3-methylimidazolium hydroxide / 3 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol at 80℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
68% | Stage #1: morpholine; 2,4-Difluoronitrobenzene In ethanol at 100℃; for 0.166667h; Flow reactor; Stage #2: With palladium 10% on activated carbon; hydrogen; morpholine hydrofluoride at 50℃; Flow reactor; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 16h; Inert atmosphere; | 47.C 7-(1-phenyl-1H-pyrazol-4-yl)-3-((2-fluoro-4-morpholinephenyl)amino)-1-methylquinoxaline-2(1H)-one Step C 7-(1-phenyl-1H-pyrazol-4-yl)-3-((2-fluoro-4-morpholinephenyl)amino)-1-methylquinoxaline-2(1H)-one Under a protection of nitrogen, to a solution of 7-(1-phenylpyrazol-4-yl)-3-bromo-1-methyl-quinoxalin-2-one (100.00mg, 253.00μmol) in dioxane (3mL) were added 2-fluoro-4-morpholine-aniline (99.29mg, 506.00μmol), cesium carbonate (247.30mg, 759.00μmol), Xantphos (14.64mg, 25.30μmol) and Pd(OAc)2 (11.36mg, 50.60μmol)), and it was stirred under nitrogen for 16 hours at 110°C. The reaction solution was cooled to room temperature, filtered through Celite and spin-dried to give a residue. The residue was separated by column to give the title compound. ES-ESI (m/z): 511 (M+H)+ |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 110 °C / Inert atmosphere 2: potassium <i>tert</i>-butylate; oxygen / dimethyl sulfoxide / 16 h / 35 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
46% | Stage #1: 4-<N-(pyridin-3-ylmethylcarbonyl)aminomethyl>benzoic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 60℃; for 3h; Stage #2: N-(3-fluoro-4-aminophenyl)morpholine With trifluoroacetic acid In tetrahydrofuran for 16h; | 2.2.3. General Procedure for the Preparation of NsubstitutedBenzamide Derivatives General procedure: CDI (1.2 mmol) was added to a suspension of compound1 (1.0 mmol) in anhydrous THF (20 mL), and the mixturewas stirred for 3h at 60°C. After formation of the acyl imidazole,the clear solution was cooled down to room temperaturefollowed by the addition of different NH2-group containingintermediates (1.1 mmol) and trifluoroacetic acid (1.1mmol). The mixture was then stirred for 16 h. The reaction mixture was evaporated to remove THF, and the crude productwas stirred in a mixture of hexane and water (2:5, v/v)for 1 h. After filteration and desiccation, the solid obtainedwas triturated with dichloromethane twice to afford puretarget compounds 2 or MS-275. 2.2.4. Pyridin-3-ylmethyl 4-(2-aminophenylcarbamoyl) benzyl-carbamate (MS-275)Yield: 68%; mp: 157-159°C (lit.[12], mp:159-160°C;1H NMR (400 MHz, DMSO-d6, ppm): δ 9.62 (s, 1H, H-23),8.60 (s, 1H, H-1), 8.53 (d, J= 3.6 Hz, 1H, H-5), 7.92-7.98(m, 3H, H-24, H-11 and H-13), 7.79 (t, J= 8.0 Hz, 1H, H-3),7.36-7.43 (m, 3H, H-4, H-10 and H-14), 7.17 (d, J= 8.0 Hz,1H, H-17), 6.97 (t, J= 7.2 Hz, 1H, H-19), 6.78 (d, J= 7.0 Hz,1H, H-18), 6.60 (t, J= 7.2 Hz, 1H, H-20), 5.10 (s, 2H, H-6),4.88 (s, 2H, H-22), 4.28 (s, 2H, H-8); 13C NMR (100 MHz,DMSO-d6, ppm): δ 165.57 (C-15), 156.72 (C-7), 149.62 (C-1), 149.60 (C-5), 143.61 (C-9), 143.59 (C-21), 136.22 (C-3),133.69 (C-12), 133.14 (C-2), 128.31 (C-11, C-13), 127.22(C-10, C-14), 127.15 (C-17), 126.93 (C-16), 124.00 (C-4),123.80 (C-18), 116.73 (C-19), 116.59 (C-20), 63.73 (C-6),44.09 (C-8). |
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3-Fluoro-4-morpholinoaniline hydrochloride
Similarity: 0.96
[ 1187582-49-5 ]
2-Fluoro-4-morpholinoaniline hydrochloride
Similarity: 0.98
[ 1187582-49-5 ]
2-Fluoro-4-morpholinoaniline hydrochloride
Similarity: 0.98
[ 2689-38-5 ]
3-Fluoro-4-morpholinoaniline hydrochloride
Similarity: 0.96
[ 1187582-49-5 ]
2-Fluoro-4-morpholinoaniline hydrochloride
Similarity: 0.98
[ 1187582-49-5 ]
2-Fluoro-4-morpholinoaniline hydrochloride
Similarity: 0.98
[ 2689-38-5 ]
3-Fluoro-4-morpholinoaniline hydrochloride
Similarity: 0.96
[ 1187582-49-5 ]
2-Fluoro-4-morpholinoaniline hydrochloride
Similarity: 0.98